Cefoxitin for Injection

Cefoxitin for Injection, USP is a broad-spectrum second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It works by inhibiting bacterial cell wall synthesis, making it effective against both Gram-positive and Gram-negative bacteria, including anaerobic organisms.

Benefits

• Broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria
• Effective for mixed infections in the abdomen, pelvis, and soft tissues
• Useful in surgical prophylaxis to prevent postoperative infections
• Bactericidal action (kills bacteria rather than inhibiting their growth)
• Can be used in certain patients allergic to penicillin (with caution)
• Stable in the presence of beta-lactamase–producing organisms

Dosage

• Dosage depends on the type and severity of the infection, patient’s age, weight, and kidney function
• Typical adult dose: 1 to 2 grams every 6 to 8 hours intravenously or intramuscularly
• For surgical prophylaxis: 2 grams administered 30 to 60 minutes before incision
• Dose adjustments may be needed in patients with renal impairment
• Always follow the dosage prescribed by your doctor or healthcare provider

Warnings and Precautions

• May cause allergic reactions, especially in patients with a history of penicillin allergy
• Prolonged use may result in overgrowth of non-susceptible organisms or superinfection
• Risk of Clostridioides difficile–associated diarrhea during or after treatment
• Monitor renal function in elderly or renally impaired patients
• Not recommended in neonates under 3 months unless directed by a healthcare provider
• Use during pregnancy or breastfeeding only under medical supervision

Usage Instructions

• To be prepared and administered by a healthcare professional only
• Reconstitute the powder using sterile water or appropriate diluent as directed
• Administer via intravenous infusion or deep intramuscular injection
• Use immediately after preparation or store according to guidelines
• Complete the full course of therapy even if symptoms improve early

Storage Information

• Store vials at 20–25°C (68–77°F)
• Protect from moisture and light
• Reconstituted solutions should be used within the recommended time frame
• Keep out of reach of children

Side Effects

• Local reactions: injection site pain, swelling, or redness
• Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain
• Skin: rash, itching
• Blood: changes in white blood cells or platelets (e.g., leukopenia, eosinophilia)
• Liver: elevated liver enzymes (AST, ALT)
• Kidney: transient increases in BUN or creatinine
• Serious (seek medical help): signs of allergic reaction (swelling of face/throat, difficulty breathing), severe diarrhea, seizures, or persistent fever