Mefoxin® Injection for Bacterial Infections

Cefoxitin is a cephamycin antibiotic used for a range of serious bacterial infections. Hospitals and infusion programs rely on it when gram-negative and anaerobic coverage is needed. We offer US delivery from Canada so you can access Canadian pricing, even when paying without insurance.

What Mefoxin Is and How It Works

Mefoxin® is the branded form of cefoxitin, a beta-lactam antibiotic in the cephamycin subgroup. It inhibits bacterial cell wall synthesis, which helps stop susceptible organisms from growing. Cefoxitin for Injection is typically chosen for infections where anaerobic coverage may be important. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine can be appropriate for intra-abdominal, gynecologic, urinary tract, lower respiratory tract, bone and joint, and skin and skin-structure infections, when caused by susceptible bacteria. It may also be used as perioperative prophylaxis in procedures with a high risk of contamination, following the official label. Selection should be guided by culture results when available and by local resistance patterns.

Who It’s For

Cefoxitin is used in adults and pediatric patients as directed by a prescriber. It treats infections due to organisms known or suspected to be susceptible. Patients with a history of severe immediate hypersensitivity to cefoxitin, other cephalosporins, or serious beta-lactam allergies should avoid it. Those with renal impairment may need adjusted dosing per label guidance. Discuss pregnancy and breastfeeding considerations with a healthcare professional.

Dosage and Usage

This treatment is given by intravenous infusion or deep intramuscular injection after reconstitution. Typical schedules follow labeled intervals, often every 6 to 8 hours for active infections. For surgical prophylaxis, timing and repeat doses follow the procedural plan and the official prescribing information. Administration is usually performed by trained staff in hospital or through home infusion services.

Only compatible diluents should be used, and infusion lines should be adequately flushed before and after other agents. Do not mix with aminoglycosides in the same solution; if both are indicated, they are administered separately. When therapy begins empirically, therapy should be reassessed once diagnostic data are available. If the organism is resistant, the prescriber may switch to an appropriate alternative.

Some patients may see improved symptoms within a few days; however, full courses are important to reduce relapse and resistance. The course length is determined by infection site, organism, and clinical response. Cefoxitin powder for injection should be prepared and administered according to the label and institutional policy.

Strengths and Forms

This medicine is supplied as a sterile powder in single-dose vials for reconstitution. A commonly requested option is the cefoxitin 1 g injection vial. Other sizes may be available, and availability can vary by supplier and country. Infusion and IM routes are both supported by the label when prepared correctly.

Missed Dose and Timing

In hospital settings, doses are scheduled by clinical teams. If you are receiving home infusions and a dose is missed, contact the prescriber or infusion service for guidance. If it is close to the next scheduled dose, do not double doses. Restart the usual schedule as directed by the care team.

Storage and Travel Basics

Unreconstituted vials are typically stored at controlled room temperature as directed on the package. Once reconstituted or diluted, stability depends on the solution and storage conditions; follow the official label and infusion pharmacy instructions. Protect from light as advised and keep supplies out of reach of children.

When traveling, keep vials, diluents, and supplies in original packaging along with the prescription label. Use a sturdy case to protect glass vials and syringes from damage. Cefoxitin USP injection should not be frozen, and any prepared solutions should be used or discarded per the specific stability guidance provided by your infusion service. Carry documentation for airport screening if flying.

Benefits

This cephamycin covers many gram-negative organisms and provides anaerobic activity that can be valuable in mixed intra-abdominal or pelvic infections. The treatment can be used for perioperative prophylaxis in selected procedures, according to labeling. It offers flexible administration options via IV infusion or IM injection. Culture-directed use helps tailor therapy and may improve outcomes.

Side Effects and Safety

• GI effects: nausea, vomiting, diarrhea
• Injection site pain or inflammation
• Rash, pruritus, or other hypersensitivity reactions
• Headache or dizziness
• Changes in lab tests, including Coombs test

Serious reactions can include anaphylaxis, severe skin reactions, Clostridioides difficile–associated diarrhea, seizures (especially with renal impairment and high exposures), and blood-related effects such as hemolytic anemia or neutropenia. Seek urgent care for severe allergic symptoms or persistent diarrhea. Antibiotics can affect gut flora; report significant GI symptoms to a clinician. If used with other agents that affect coagulation, monitoring may be needed.

Drug Interactions and Cautions

Probenecid can increase cefoxitin levels by reducing renal tubular secretion. Concomitant use with potent diuretics or other nephrotoxic drugs may elevate renal risk. Avoid mixing with aminoglycosides in the same IV solution. As with other antibiotics, live bacterial vaccines may have reduced effectiveness. Cephalosporins can interact with some anticoagulants; clinicians may choose to monitor coagulation parameters.

Adjustments may be needed for patients with reduced kidney function. A history of beta-lactam allergy requires careful evaluation due to potential cross-reactivity. Use during pregnancy or breastfeeding should be evaluated by a prescriber against clinical need and available safety data. Always review the full prescribing information for detailed interaction guidance.

What to Expect Over Time

Symptoms may begin to improve after several doses as bacterial growth is inhibited. Lab markers and clinical signs guide decisions about continuing or revising therapy. Completing the prescribed course helps reduce the chance of recurrence and resistance. If cultures identify a resistant organism, a different antibiotic may be selected. Patients on longer courses, such as for bone or joint infections, may have periodic lab monitoring.

Compare With Alternatives

Several antibiotics may be considered depending on culture results, site of infection, and patient factors. For skin and soft tissue infections caused by susceptible organisms, oral options like Cephalexin may be used when appropriate. For certain gram-negative infections per susceptibility testing, Ciprofloxacin HCl can be considered. The prescriber ultimately selects the most suitable medicine based on the label and local guidelines.

Pricing and Access

We help patients compare cefoxitin injection price against typical cash-pay rates. Many choose generic formulations to stretch budgets when paying out of pocket. You can review Canadian pricing with US shipping from Canada and see options that fit your treatment plan. Our checkout is encrypted, and orders require a valid prescription.

For those who self pay, buying enough for the full prescribed course can reduce repeat fulfilment fees. If your therapy is extended, your prescriber can provide updated directions for the pharmacy. Contact support if your prescription directions need clarification before dispensing.

Availability and Substitutions

Supply can vary. If your selection is unavailable at the time of review, a prescriber may recommend a suitable alternative that meets your clinical needs. We list generic cefoxitin injection when stocked, and equivalent presentations may be offered from different manufacturers. Country-of-origin details are noted on product pages; see Country Of Origin Canada for more context.

Patient Suitability and Cost-Saving Tips

Good candidates are patients with confirmed or suspected susceptible infections and no history of severe immediate beta-lactam hypersensitivity. Those with severe penicillin or cephalosporin reactions should avoid use. People with kidney impairment may need careful monitoring and adjusted schedules per the label.

Cost-saving ideas include requesting multi-vial fills for a complete course when appropriate, which may reduce per-order fees. Set reminders so you don’t miss clinic visits or home infusion sessions. If your treatment extends beyond the initial plan, ask your prescriber to update directions so you can secure the next allotment in one fulfilment.

Questions to Ask Your Clinician

• Target organisms: Which bacteria are suspected, and will cultures be taken?
• Duration: How long is therapy expected based on the site of infection?
• Administration: Will this be IV infusion, IM, or both during the course?
• Monitoring: What labs or signs should be watched for during treatment?
• Alternatives: If resistance is found, which options are considered next?
• Safety: What symptoms should prompt urgent medical attention?

Authoritative Sources

DailyMed: Cefoxitin for Injection (Mefoxin) Prescribing Information

Health Canada Drug Product Database

Manufacturer Information

Storage and Travel Basics

For day-to-day handling at home or during transport to infusion centers, keep supplies together in a clean, dry case. Do not expose prepared solutions to extreme temperatures; ask your infusion pharmacy about stability windows. If traveling, bring enough vials and diluent for your itinerary plus written instructions. Pack a copy of your prescription and any administration schedule provided by the clinic.

Dispose of used needles, syringes, and tubing per local regulations and your infusion service’s instructions. Never reuse single-use supplies. If spills occur, follow the clean-up guidance from your provider and wash hands thoroughly. Temperature-controlled handling when required is arranged by the dispensing pharmacy.

Many infections treated with this therapy overlap with recognized clinical categories. Learn more in our condition guides for Intra Abdominal Infection, Urinary Tract Infection, and Respiratory Tract Infection. For broader context on antimicrobial options, see our Antibiotics category or the overview of Bacterial Infection. For public health insights, you can also read Respiratory Care Week 2025. Skin and soft tissue coverage is discussed under Skin And Soft Tissue Infection.

Ready to proceed? You can order cefoxitin sodium injection with prompt, express shipping and US shipping from Canada. Always use as prescribed by your clinician. This page is informational and does not replace professional medical advice.