Estrogel® Gel for Menopausal Symptoms

Estrogel® is a prescription estradiol gel used to treat bothersome menopause symptoms. This page explains how it works, how to use it, and key safety considerations so you can talk with your prescriber. You can access US delivery from Canada, including clear options for those paying without insurance.

What Estrogel Is and How It Works

This medicine is a transdermal estrogen therapy. It delivers estradiol through the skin into the bloodstream to help reduce hot flashes, night sweats, and other vasomotor symptoms. By replacing declining estrogen, it acts on estrogen receptors in the brain, blood vessels, and other tissues associated with menopause symptoms.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The gel is applied to the skin once daily. It avoids first-pass liver metabolism seen with oral estrogen, which may reduce certain metabolism-related interactions. It should be used at the lowest effective dose for the shortest time that meets treatment goals, consistent with labeling.

For women with a uterus, a progestin is often prescribed alongside systemic estrogen to reduce the risk of endometrial hyperplasia. Your prescriber will determine if this is appropriate for you.

For details on symptom patterns and care, you can also review our Menopausal Symptoms hub and this overview of alternatives like Premarin Hot Flashes.

Who It’s For

This treatment is indicated for moderate to severe vasomotor symptoms due to menopause. It may also be prescribed for hypoestrogenism when estrogen therapy is appropriate. Some patients with genitourinary syndrome of menopause may be better served with local vaginal estrogen, depending on goals.

Do not use if you have a history of breast cancer or estrogen-dependent tumors, active or past blood clots, stroke, heart attack, liver impairment, or unexplained vaginal bleeding. It is not for pregnancy. This is an Estradiol transdermal gel 0.06, so your prescriber will confirm whether systemic estrogen is right for your situation.

Dosage and Usage

Use exactly as directed on your prescription label. The gel is typically applied once daily to clean, dry, unbroken skin on the arm. Spread the measured amount over the recommended area and allow it to dry completely before dressing.

• Site choice: Apply to the arm from wrist to shoulder, or as your prescriber directs.
• Clean skin: Avoid applying over lotions, perfumes, or irritated skin.
• Dry time: Let the gel dry fully before covering with clothes.
• Hands: Wash hands with soap and water after application.
• Contact: Avoid skin-to-skin transfer until the application site is dry.
• Bathing: Wait at least one hour before bathing or swimming, per label guidance.

If your prescriber adds a progestin, follow those instructions exactly. Never apply to the breasts or near the vagina. Do not change your dose without medical advice.

To learn more about other prescription options in women’s care, explore Womens Health.

Strengths and Forms

This product is available as a metered-dose pump. The commonly supplied container is an 80 g canister. The labeled concentration is 0.06%. Availability may vary by partner pharmacy and region.

• Form: Transdermal gel in a pump canister
• Canister size: 80 g (typical presentation)
• Dosing: Metered actuations per label

Country of origin for a given lot may vary; see our attribute page for Canada when relevant to supply.

Missed Dose and Timing

If you miss a dose, apply it as soon as you remember on the same day. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double up. Try setting a daily reminder to help keep a steady routine.

Storage and Travel Basics

Store the canister at room temperature away from heat and direct light. Keep the cap on when not in use. Do not freeze. Keep out of reach of children and pets. When traveling, carry your prescription-labeled container in your hand luggage, along with a copy of your prescription.

If asked at security, explain that this is a prescribed topical hormone. Avoid leaving the canister in a hot car. When staying at hotels, store it in a cool, dry place away from direct sun. For reference in some markets, this therapy is also known as Besins Estrogel gel.

Benefits

When used as directed, this systemic estrogen therapy can reduce the frequency and intensity of hot flashes and night sweats. Many patients find once-daily application convenient. The transdermal route may offer steady hormone levels throughout the day. Your prescriber can adjust the regimen to balance symptom relief with safety goals.

For additional background on estrogen therapies in menopause, you can review Premarin For Menopause for context only.

Side Effects and Safety

• Headache or migraine
• Breast tenderness
• Nausea or abdominal discomfort
• Mood changes
• Application-site irritation
• Vaginal spotting

Serious risks may include blood clots, stroke, heart attack, gallbladder disease, high blood pressure, and certain cancers. Unopposed estrogen increases the risk of endometrial hyperplasia; a progestin is generally recommended if you have a uterus. Stop the medicine and seek urgent care if you develop chest pain, shortness of breath, sudden weakness, or severe headache. Review your personal and family risk factors with your clinician before starting.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements you use. Strong enzyme inducers such as carbamazepine, phenytoin, and St. John’s wort may lower estradiol exposure. Some antifungals and certain antibiotics may increase exposure. Thyroid replacement, corticosteroids, and anticoagulants may require monitoring when taken with systemic estrogen. Limit alcohol and discuss any history of migraines, high triglycerides, or liver disease before use.

What to Expect Over Time

Consistent daily use is important. Many people notice gradual changes as the treatment reaches steady levels. Keep a simple symptom diary to track hot flashes, night sweats, and sleep quality. Share that record during follow-up visits so your clinician can evaluate whether the current regimen still fits your goals. If your situation changes, your prescriber may reassess therapy benefits and risks.

Compare With Alternatives

Some patients with primarily vaginal symptoms may consider a local estrogen option such as Imvexxy. For specific conditions like endometriosis or fibroid-related symptoms, your prescriber may discuss alternatives such as Myfembree. Your healthcare professional can help determine which therapy best aligns with your needs and risk profile.

Pricing and Access

Check current pricing on this page and talk with your prescriber about options that fit your plan. Cash-pay users often ask about the Estrogel price without insurance; we show transparent pricing when available. Ordering through our partners reflects Canadian pricing, and products Ships from Canada to US for fulfillment. We use encrypted checkout to protect your information. If you are comparing seasonal specials, you can review our Promotions page.

For related reading as you plan your care, see Premarin Hot Flashes and our condition guide for Menopausal Symptoms.

Availability and Substitutions

Inventory can vary. If the exact presentation is temporarily unavailable, your prescriber may suggest a comparable systemic or local estrogen option, or a different dosing schedule. Our pharmacists dispense only against a valid prescription and will not change your therapy without your clinician’s authorization. If you prefer to compare online options, you can discuss Estrogel gel online versus other formulations during your clinical visit.

Patient Suitability and Cost-Saving Tips

This treatment may suit postmenopausal adults seeking relief from moderate to severe vasomotor symptoms who do not have contraindications to estrogen. It is not intended for pregnancy or for prevention of cardiovascular disease or dementia. Share your full medical history, including clotting risks and cancer history, with your prescriber.

• Multi-month fills: Ask about 60–90 day supplies to reduce trips.
• Refill reminders: Set calendar alerts so you do not run out.
• Application routine: Keep the canister in a visible, safe spot.
• Travel prep: Pack extra days and your prescription label.
• Follow-ups: Schedule periodic reviews to reassess benefits and risks.

Questions to Ask Your Clinician

• What goals should I expect with this therapy, and how will we measure them?
• Do I need a progestin with this treatment based on my history?
• Which application site is best for me, and what should I avoid?
• How will my other medicines and supplements interact with estrogen therapy?
• What warning signs should prompt me to stop and call for help?
• How often should we reassess whether I should continue or adjust the dose?

Authoritative Sources

Manufacturer: EstroGel (Besins)

FDA DailyMed: EstroGel Label

Health Canada DPD: Oestrogel

Ready when you are: Add to cart and proceed to checkout for US shipping from Canada with prompt, express shipping. Always follow your prescriber’s directions. This information is educational and not a substitute for professional medical advice.