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Evenity® Injection for Osteoporosis
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Evenity is a prescription bone-building treatment for osteoporosis in adults at high risk for fracture. It is started and supervised by a healthcare professional. This page explains how the medicine works, who it may suit, and how you can order with US delivery from Canada, including options if you pay without insurance.
What Evenity Is and How It Works
Evenity® contains romosozumab, an antibody that blocks sclerostin. By inhibiting sclerostin, the treatment increases bone formation and, to a lesser degree, reduces bone breakdown. It is given as two subcutaneous injections during the same visit each month for a limited course.
Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.
This romosozumab injection is intended for use under clinician oversight. Before starting, your prescriber may check for low calcium and review your fracture risk, heart history, and dental health. Patients are usually advised to take calcium and vitamin D as directed.
Who It’s For
This medicine is indicated for osteoporosis in postmenopausal women and in men who are at high risk for fracture. High risk can include a history of osteoporotic fracture, multiple risk factors, or failure or intolerance to other therapies.
People with a recent heart attack or stroke (within the past year) should not start this treatment. Those with low blood calcium should have levels corrected before the first dose. If you have severe kidney problems or are on dialysis, your prescriber may monitor calcium more closely. For broader context on bone health, see Osteoporosis and women’s health topics under Womens Health. Related life-stage considerations are discussed in Menopause And Beyond.
Dosage and Usage
Administration is once monthly as two injections at the same visit. A healthcare professional gives the doses under the skin, typically in the abdomen, thigh, or upper arm. Treatment is limited to 12 doses. After completing the course, many patients transition to a different osteoporosis therapy to help maintain bone density gains, according to the prescriber’s plan.
Eat normally and stay hydrated on dosing days unless told otherwise. If you take calcium or vitamin D, continue as directed. Your clinician may advise routine dental care and reporting of any new thigh, hip, or groin pain.
Strengths and Forms
The product is supplied as prefilled syringes for subcutaneous use. A single treatment visit uses two syringes to deliver the full monthly dose.
Commonly referenced presentations include Evenity 210 mg per monthly dose and syringes containing 105 mg each. Availability can vary by pharmacy and lot. For origin details, see Canada.
Missed Dose and Timing
If a monthly visit is missed, contact your clinic as soon as possible to reschedule. The next visits are usually timed monthly from the new date. Do not attempt home administration unless your prescriber has arranged appropriate care. For clarity on scheduling, your care team can advise on Evenity dosing in clinic workflows.
Storage and Travel Basics
Pharmacies store this medicine refrigerated in its original carton. Keep syringes in the carton to protect from light. Do not freeze. If you are transporting the product to a clinic, follow the pharmacy’s instructions carefully and keep it in the provided packaging. At home, store out of reach of children and pets.
When traveling, bring your prescription details and clinic contact information. Use a travel case if instructed. Do not expose the syringes to extreme heat or direct sunlight. If you have questions about time out of the refrigerator, follow the official label or ask your healthcare professional.
Benefits
This bone-forming therapy can increase bone mineral density at the spine and hip. It may reduce the risk of fractures, especially vertebral fractures, in appropriate patients. Monthly in-clinic dosing can support adherence by pairing each visit with routine check-ins. After the course ends, prescribers often continue care with another osteoporosis treatment to help preserve gains.
Side Effects and Safety
- Injection site redness or discomfort
- Joint or muscle pain
- Headache
- Flu-like symptoms
Serious risks can include heart attack, stroke, severe allergic reactions, low blood calcium, osteonecrosis of the jaw, and atypical femur fractures. Do not start if you had a heart attack or stroke within the past year. Tell your clinician about jaw problems, dental procedures, or new thigh, hip, or groin pain. Seek emergency care for symptoms of heart attack, stroke, or severe allergy.
Drug Interactions and Cautions
Few classic drug–drug interactions are documented for romosozumab AQQG, but clinical review is important. Tell your prescriber about all medicines, vitamins, and supplements. Low calcium must be corrected before treatment. Dental evaluation may be recommended, especially if you have risk factors for jaw problems. People with severe kidney impairment may have a higher risk of low calcium and need closer monitoring.
What to Expect Over Time
BMD improvements can begin within months, and the full course lasts one year in most cases. Your clinician may order periodic labs or imaging to monitor progress and safety. Many patients transition to an antiresorptive medication after completing therapy to help maintain gains. Good calcium and vitamin D intake, weight-bearing activity as advised, and fall-prevention strategies can support your long-term plan. For background reading, see Metformin Emerging Evidence and Metformin Unlocking Its.
Compare With Alternatives
Options for high-risk osteoporosis include other bone-modifying agents and antiresorptives. Denosumab is a common follow-on or alternative chosen by prescribers. You can review Prolia Prefilled Syringe for comparison. Oral or IV bisphosphonates may also be used when appropriate; your clinician can advise which path fits your history and fracture risk.
Pricing and Access
Canadian pharmacy networks can offer competitive pricing for specialty therapies with US shipping from Canada. For current options and availability, check our product page and verify your prescription details at checkout. If you look for savings tools, see eligible site offers on Promotions. Ask your prescriber or insurer about coverage and prior authorization requirements.
Our checkout uses encrypted processing. For a detailed discussion of budget considerations, your clinician or pharmacist can outline assistance programs and practical next steps. Patients paying cash can still track total costs and plan refills with reminders.
For transparency on the Evenity injection price, view the listing for current figures rather than estimates. Published amounts can change with supply and manufacturer updates.
Availability and Substitutions
Supply can vary. If this item is unavailable, your prescriber may recommend a different therapy class or timing adjustments. Pharmacies dispense the specific brand requested when prescribed. If substitution is considered, it requires prescriber approval.
Patient Suitability and Cost-Saving Tips
Good candidates are adults with osteoporosis at high fracture risk who do not have recent major cardiovascular events. People with ongoing hypocalcemia should wait until levels are corrected. Your prescriber will weigh benefits and risks in the context of your history and medications.
- Multi-month planning: schedule monthly visits ahead
- Refill reminders: set calendar alerts
- Dental care: routine checks during therapy
- Supplements: calcium and vitamin D as directed
- Fall prevention: home safety and balance training
Self-pay shoppers sometimes compare romosozumab price across pharmacies and adjust their fill timing accordingly. You can also review menopause care topics in Premarin For Menopause for broader bone health context.
Questions to Ask Your Clinician
- Is my fracture risk high enough to benefit from this therapy?
- How will you monitor calcium, heart health, and jaw symptoms?
- What daily calcium and vitamin D amounts should I take?
- Which medicine will follow the monthly course to maintain gains?
- How should we handle a missed monthly visit?
- Do my other conditions change the risk–benefit balance?
Authoritative Sources
| Reference | Link |
|---|---|
| Amgen Product Information | Manufacturer Site |
| US Prescribing Information | DailyMed |
| Health Canada Database | DPD Entry |
Note: Always follow the official label and your clinician’s instructions for dosing, monitoring, and safety.
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How is this treatment given and who administers it?
It is administered as two subcutaneous injections during the same visit once each month. A healthcare professional gives the dose, usually in the abdomen, thigh, or upper arm. The course is limited to one year. Your care team will schedule monthly visits and may advise calcium and vitamin D. Do not try to inject at home unless specifically arranged by your prescriber. Follow clinic guidance if an appointment is delayed.
What are the most important safety warnings?
There is a risk of heart attack, stroke, and cardiovascular death. Do not start if you had a heart attack or stroke in the past year. Low blood calcium must be corrected before treatment. Potential serious reactions include severe allergy, osteonecrosis of the jaw, and atypical femur fractures. Report jaw pain, dental issues, or new thigh, hip, or groin pain. Your clinician will assess individual risks and monitor as needed.
What if I miss a monthly visit?
Call your clinic as soon as possible to reschedule. The next appointments are usually timed monthly from the new date. Do not attempt to self-inject. Keep taking calcium and vitamin D as directed unless your prescriber advises otherwise. Your care team can align future visits with your schedule to support adherence.
Can I take it with my other medications?
Few classic drug–drug interactions are known for this medicine, but a full review is still important. Share all medicines, vitamins, and supplements with your healthcare professional. People with severe kidney impairment may have a higher risk of low calcium and need monitoring. Your clinician will check your heart history, dental status, and lab values before and during therapy.
How long will I be on therapy?
The usual course is 12 doses. After completing the one-year course, many patients are transitioned to an antiresorptive medicine to help maintain bone density gains. Your clinician will tailor the plan to your fracture risk, past treatments, and monitoring results. Do not stop or switch medicines without clinical guidance.
What benefits should I expect?
This bone-forming therapy can increase bone mineral density and may reduce the risk of fractures, especially in the spine. Improvements can appear within months, but your clinician will set realistic expectations and monitor progress. Calcium and vitamin D intake, fall-prevention steps, and follow-up therapy after the course can support long-term results.
How is pricing handled for U.S. orders?
Pricing reflects Canadian pharmacy sourcing and can change with supply. You can view current figures on the product page at checkout. Insurance coverage varies by plan and may require prior authorization. Cash-pay patients can still compare options and set refill reminders. Our checkout is encrypted, and a valid prescription is required.
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