Invokamet® Tablets for Type 2 Diabetes

What Invokamet Is and How It Works

Invokamet® is a prescription medicine for adults with type 2 diabetes. It combines canagliflozin, an SGLT2 inhibitor, with metformin, a biguanide, to help lower blood sugar when used with diet and exercise. With US shipping from Canada, this guide explains how the combination works, who it may suit, and ways to manage costs without insurance.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Canagliflozin reduces glucose reabsorption in the kidneys, which increases urinary glucose excretion. Metformin decreases hepatic glucose production and improves insulin sensitivity. Together, the class pairing targets complementary pathways that can lower A1C and support overall glycemic control. Many patients also notice modest diuresis at first as the kidney effect begins.

As with all prescription therapies, safety comes first. The treatment is not insulin and does not replace lifestyle measures. Your prescriber will review medical history, kidney function, and other medicines before deciding if this combination is appropriate.

For clarity, this page focuses on the immediate-release tablet. Extended-release options exist but follow different dosing schedules. When uncertain, follow the official label and your clinician’s guidance.

Who It’s For

This medicine is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It is not for type 1 diabetes and not for treatment of diabetic ketoacidosis. People with significantly reduced kidney function may not be candidates, and those with moderate impairment may require close monitoring. Discuss pregnancy planning and breastfeeding with your clinician, as use may be limited. Individuals with a history of recurrent genital infections, volume depletion, or risk of lactic acidosis need careful evaluation before starting.

Dosage and Usage

Typical use is twice daily with meals. Taking doses with food helps reduce gastrointestinal upset from the metformin component. Swallow tablets whole with water. Your prescriber will individualize the starting dose based on current therapies, A1C, and kidney function. If you are already taking metformin, the metformin amount is usually maintained while adding the SGLT2 component. Do not crush or split unless your prescriber advises otherwise.

Hydration matters. Increased urination can occur, so drink water regularly unless otherwise instructed. Monitor blood glucose as directed, and report any signs of dizziness, persistent stomach upset, or unusual fatigue. If you notice symptoms of infection in the genital area or urinary tract, contact your healthcare professional promptly.

Before iodinated contrast imaging, metformin-containing products may need temporary interruption to reduce lactic acidosis risk; your prescriber will advise. Always carry a list of medicines and doses when visiting clinics or hospitals.

Strengths and Forms

This combination is supplied as oral tablets. Availability can vary by partner pharmacy and country of origin.

• 50 mg/500 mg
• 50 mg/1000 mg
• 150 mg/500 mg
• 150 mg/1000 mg

Ask your prescriber which strength aligns with your current regimen. If your plan includes a switch between strengths, the pharmacy team will coordinate a new prescription. Patients seeking convenience often ask about Invokamet tablets; confirm the specific strength on your script before checkout.

Missed Dose and Timing

If you miss a dose, take it with food when you remember on the same day. If it is almost time for the next dose, skip the missed one and resume your usual schedule. Do not double doses. Keep a simple routine, such as pairing doses with breakfast and dinner, to reduce missed tablets.

Storage and Travel Basics

Store tablets at room temperature in a dry place and keep the bottle tightly closed. Protect from moisture and keep out of reach of children and pets. When traveling, carry medicines in original labeled containers and pack them in your hand luggage. A copy of your prescription or a photo of the label can help during security checks. For longer trips, set reminders on your phone and bring extra days of therapy in case plans change.

Benefits

This combination offers two complementary mechanisms in one prescription. The SGLT2 component helps the kidneys remove excess glucose, while metformin targets liver glucose production. Many adults appreciate fewer separate pills and a routine tied to meals. Some people may experience modest weight neutrality or slight reduction, although individual responses vary. The therapy can be combined with other non-insulin agents when clinically appropriate to further support A1C goals.

Side Effects and Safety

• Genital yeast infections
• Urinary tract infections
• Increased urination
• Thirst or dizziness from volume loss
• Stomach upset, diarrhea, or nausea
• Headache

Serious risks are uncommon but important. Lactic acidosis is a rare metformin-associated emergency; symptoms include rapid breathing, severe fatigue, and abdominal pain. The SGLT2 component can, rarely, contribute to ketoacidosis, even with near-normal glucose, especially during illness or reduced intake. Serious urinary or genital infections, including rare cases of Fournier’s gangrene, have been reported. Bone fracture risk and lower-limb amputation risk have been observed with canagliflozin; your clinician will weigh benefits and risks. Acute kidney injury can occur, particularly with dehydration or certain medicines.

When combined with insulin or a sulfonylurea, the risk of hypoglycemia increases; monitor closely and discuss with your prescriber. Report allergic reactions, severe rash, or swelling immediately. If you become sick, cannot maintain fluids, or plan surgery, call your healthcare professional for guidance.

Drug Interactions and Cautions

Diuretics, ACE inhibitors, and ARBs can add to volume depletion or affect kidney function; you may need closer monitoring. Alcohol can increase the risk of lactic acidosis with metformin. Contrast dye procedures often require temporary pause of metformin-containing products. Insulin and sulfonylureas increase hypoglycemia risk when used together with this therapy; your clinician may adjust other medicines. Review over-the-counter products and herbal supplements during each visit. If you use SGLT2 therapy during prolonged fasting, heavy exercise, or acute illness, watch for signs of ketoacidosis and seek medical advice if symptoms develop.

What to Expect Over Time

Many patients see improved fasting and post-meal readings as adherence continues. Early on, you may notice more frequent urination and increased thirst; these effects often settle after the first weeks as your body adapts. Yeast infections can occur; fast recognition and treatment help. A1C is typically assessed every three months to evaluate progress. Set simple routines around meals and medicines, and keep follow-up appointments so your prescriber can review labs and kidney function regularly.

Compare With Alternatives

Several other combination tablets offer similar goals with different SGLT2 agents. Empagliflozin plus metformin is available as Synjardy, while dapagliflozin plus metformin is offered as Xigduo 60 Tablets. Some patients may instead use a single SGLT2 agent paired with standalone metformin. Your clinician can help choose among classes based on A1C targets, kidney function, and tolerability.

Pricing and Access

Canadian pharmacy pricing can be lower than typical U.S. cash rates, with fulfilment that Ships from Canada to US. To compare options, review Invokamet price details on the product page, then discuss supply lengths with your prescriber. If you prefer to view options by class rather than brand, you can also look up Canagliflozin metformin price information to understand how strengths and pack sizes influence your out-of-pocket costs. For current offers across the site, see our Promotions page. Checkout uses encrypted checkout to protect your information.

Two quick actions can help you evaluate savings: first, check your plan’s pharmacy benefit for coverage tiers; second, compare Canadian pricing against your local cash-pay quote. If your clinician approves a 90-day supply, you may reduce refill frequency and handling costs.

Explore related care supplies and education under Diabetes Care and condition resources in Type 2 Diabetes. For country-of-origin details, review Canada listings on qualifying items.

Availability and Substitutions

Supply can vary by strength. If a selected strength is unavailable, your prescriber may recommend an alternative strength or a different SGLT2 plus metformin product. Ask our team about any active Invokamet coupon or site-wide offer if available, and consult your clinician before any switch to alternative therapies.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults needing dual action when metformin alone is not enough. It may not suit those with severe kidney disease, unstable cardiovascular status, frequent genital infections, or conditions that raise lactic acidosis risk. Older adults, those on diuretics, and patients with low blood pressure need careful hydration and monitoring. Discuss foot care if you have peripheral vascular disease or neuropathy.

Practical ways to manage Invokamet cost include asking your prescriber about a 60- or 90-day prescription, setting calendar reminders for refills, and aligning refills for all diabetes medicines on the same date. If you and your clinician decide to continue long term, multi-month supplies can help reduce per-fill fees. Keep a printed medication list in your wallet to simplify pharmacy coordination.

Questions to Ask Your Clinician

• Is this combination appropriate for my A1C target and kidney function?
• How should I coordinate doses with meals and other medicines?
• What symptoms should prompt a call, especially for dehydration or infection?
• How will we monitor labs and adjust if side effects occur?
• Could another SGLT2 combination or class be a better fit?
• What is the plan around surgery, illness, or contrast imaging?

Authoritative Sources

Manufacturer Prescribing Information

FDA DailyMed

Health Canada DPD

Ready to proceed? Add your prescription and complete checkout for prompt, express shipping with temperature-controlled handling when required. All orders are pharmacist-verified and dispensed against a valid prescription.

Disclaimer: This page offers general information and is not a substitute for professional medical advice. Always follow your prescriber’s instructions and the official label.