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Invokamet is a canagliflozin and metformin tablet used with diet and exercise to help improve blood sugar control in type 2 diabetes. It can be ordered online with US delivery from Canada, and you can choose the available strength that matches the directions from your clinician.
This combination brings together two established diabetes medicines in one tablet. Canagliflozin belongs to the SGLT2 inhibitor class, which helps the kidneys remove extra glucose through urine, while metformin helps reduce liver glucose production and improve insulin sensitivity.
Invokamet Price, Strength Selection, and Ordering
Invokamet price can vary by tablet strength, quantity, and the supply chosen during checkout. The most practical way to evaluate Invokamet cost is to match the strength on your medication directions, then review the current cash-pay amount before completing the order. If your clinician has written for a longer supply, ordering fewer refills over time may help reduce repeated handling steps.
Invokamet tablets are immediate-release combination tablets. The strengths commonly referenced for this product are based on canagliflozin and metformin amounts in the same tablet:
- 50 mg/500 mg
- 50 mg/1000 mg
- 150 mg/500 mg
- 150 mg/1000 mg
Choose the exact strength that aligns with your medication directions. Invokamet XR is a related extended-release version, but it follows a different release pattern and dosing schedule. Do not substitute immediate-release and extended-release tablets unless your healthcare professional specifically directs that change.
Quick tip: Keep the canagliflozin amount and the metformin amount together when checking your strength, such as 50 mg/1000 mg or 150 mg/1000 mg.
What Invokamet Treats
Invokamet is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes. It is not used to treat type 1 diabetes, and it is not a treatment for diabetic ketoacidosis. Your overall plan may also include nutrition changes, physical activity, glucose monitoring, and other diabetes medicines.
People browsing broader diabetes treatment categories can also explore Type 2 Diabetes information and related products in Diabetes Care. Those sections can help you organize glucose-testing supplies, oral medicines, and related support items in one place.
Invokamet may be considered when metformin alone is not enough, or when a clinician wants an SGLT2 inhibitor and metformin in one tablet. Because kidney function affects how this combination is used, laboratory monitoring is an important part of ongoing care.
How the Active Ingredients Work
Canagliflozin is the same active SGLT2 inhibitor found in Invokana. SGLT2 inhibitors reduce glucose reabsorption in the kidneys, so more glucose leaves the body in urine. This kidney effect can also cause increased urination, especially near the start of therapy.
Metformin is a biguanide. It mainly lowers glucose production by the liver and improves how the body responds to insulin. Invokamet contains metformin, so it carries metformin-related precautions, including gastrointestinal side effects and the rare but serious risk of lactic acidosis.
The difference between Invokana and metformin is that Invokana refers to canagliflozin, while metformin is a separate active ingredient from a different drug class. Invokamet combines canagliflozin plus metformin in one tablet, which can reduce the number of separate tablets for some people.
How to Take the Tablets
Immediate-release Invokamet is typically taken with meals. Taking it with food helps reduce stomach upset from the metformin component. Swallow tablets with water, and follow the schedule provided by your healthcare professional rather than changing timing on your own.
If a dose is missed, many labels advise taking it with food when remembered on the same day. If the next scheduled dose is close, skip the missed dose and return to the usual routine. Do not double up to make up for a missed tablet.
Hydration matters with SGLT2 medicines because the kidney effect can increase urination. Contact a healthcare professional if you develop dizziness, vomiting, reduced fluid intake, or signs of dehydration. Temporary treatment interruptions may be needed around certain medical procedures, surgery, serious illness, or contrast imaging.
Benefits and What to Expect
Invokamet targets blood sugar through two complementary pathways. Canagliflozin increases urinary glucose removal, while metformin addresses glucose production and insulin sensitivity. For some people, having both ingredients in one tablet can simplify a routine that would otherwise involve separate medicines.
A1C is usually assessed over several months, so progress is often evaluated at follow-up visits rather than day to day. Home glucose readings may change earlier, especially fasting or post-meal readings, but individual response varies. Keep your monitoring routine consistent so your clinician has useful information for decisions.
Some people ask whether Invokamet causes weight loss. SGLT2 inhibitors may be associated with modest weight reduction in some patients, while metformin is often weight-neutral or modestly weight-lowering for some. Invokamet should not be used as a weight-loss medicine, and any weight change should be discussed in the context of diabetes care, hydration, and nutrition.
Side Effects, Warnings, and Monitoring
Common side effects can include genital yeast infections, urinary tract infections, increased urination, thirst, nausea, diarrhea, stomach upset, headache, or dizziness. Genital or urinary symptoms should be addressed promptly, especially if they are painful, recurrent, or accompanied by fever.
Serious but less common risks need careful attention. Metformin can rarely cause lactic acidosis, a medical emergency that may involve severe weakness, unusual sleepiness, rapid breathing, abdominal pain, or feeling cold. Canagliflozin and other SGLT2 inhibitors have been associated with ketoacidosis, sometimes with blood glucose that is not extremely high. Seek urgent care for nausea, vomiting, abdominal pain, trouble breathing, confusion, or unusual fatigue.
Canagliflozin has also been associated with dehydration, low blood pressure, acute kidney injury, serious urinary infections, rare serious genital infections, bone fracture risk, and lower-limb amputation risk. Foot care is especially important for people with neuropathy, poor circulation, prior ulcers, or past amputations. Report new foot pain, sores, tenderness, infection, or color changes quickly.
Kidney function should be assessed before and during therapy. This combination may not be appropriate for people with significantly reduced kidney function, metabolic acidosis, diabetic ketoacidosis, or conditions that raise lactic acidosis risk. Older adults, people taking diuretics, and those with low blood pressure may need closer monitoring for volume loss.
Hypoglycemia is not usually the main effect of SGLT2 inhibitors or metformin when used alone, but the risk can rise when Invokamet is combined with insulin or medicines that increase insulin release, such as sulfonylureas. Symptoms may include shakiness, sweating, hunger, fast heartbeat, confusion, or weakness. Ask your clinician how to handle low readings if other glucose-lowering medicines are part of your regimen.
Interactions and Situations That Need Extra Care
Alcohol can increase the risk of lactic acidosis with metformin, especially with heavy or binge drinking. Diuretics may add to fluid loss, and medicines that affect kidney function can change how safely this combination is used. Share all prescription medicines, over-the-counter products, and supplements at each visit.
Iodinated contrast imaging may require a temporary pause of metformin-containing medicines in certain patients. Surgery, prolonged fasting, acute illness, reduced food intake, heavy exercise, or dehydration may increase the risk of ketoacidosis with SGLT2 therapy. Your healthcare team can tell you when to hold or restart medicines in those situations.
Pregnancy planning and breastfeeding should be discussed before continuing therapy. Labeling for SGLT2 inhibitors includes limitations during later pregnancy because of kidney-development concerns seen in nonclinical data. Your clinician can weigh the diabetes-control needs and alternative treatment choices.
Storage, Travel, and Delivery
Store Invokamet tablets at room temperature in a dry place, with the bottle tightly closed. Keep tablets away from excess moisture, children, and pets. Do not store the bottle in a bathroom cabinet if humidity is high.
When traveling, carry tablets in the original labeled container and keep them in hand luggage. Bring enough supply for schedule changes, and set reminders if crossing time zones. A current medication list can help during clinic, urgent care, or airport-security interactions.
Orders may use prompt, express shipping. If country-of-origin information matters for your purchase planning, qualifying products can be browsed through Canada listings.
Comparing Invokamet With Related Options
Invokamet is one way to combine an SGLT2 inhibitor with metformin. A clinician may instead use a single SGLT2 inhibitor plus standalone metformin, an extended-release combination, or another diabetes class depending on A1C goals, kidney function, cardiovascular history, side effects, and treatment preferences.
Invokamet XR contains the same active-ingredient pairing but uses an extended-release metformin formulation. The XR version may fit different dosing routines, yet it is not interchangeable with immediate-release tablets without a clinician’s direction. Strength names can look similar, so confirm both active-ingredient amounts before changing products.
People who want broader educational reading can browse type 2 diabetes articles. Use those materials for background only; individualized medicine decisions should remain tied to your clinical history and lab results.
Questions to Ask Before Continuing Therapy
Invokamet works best when the strength, meal timing, monitoring plan, and safety precautions are clear. Before starting or refilling, ask how often kidney function should be checked, what glucose targets you are using, and whether any other diabetes medicines raise your low-blood-sugar risk.
It is also reasonable to ask what symptoms should trigger urgent care, what to do during vomiting or dehydration, and whether the medicine should be paused before surgery or contrast imaging. If you have frequent urinary or genital infections, foot problems, low blood pressure, or a history of kidney disease, make those concerns part of the discussion.
Authoritative Sources
Official prescribing information
This content is for informational purposes only and is not a substitute for professional medical advice.
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Does Invokamet contain metformin?
Yes. Invokamet combines canagliflozin with metformin hydrochloride in one tablet. The strength shows both amounts, such as canagliflozin 50 mg with metformin 500 mg or 1000 mg.
What is the difference between Invokana and metformin?
Invokana is canagliflozin, an SGLT2 inhibitor that helps the kidneys remove glucose through urine. Metformin is a biguanide that mainly reduces glucose production by the liver. Invokamet contains both active ingredients.
Is Invokamet used for type 1 diabetes?
No. Invokamet is indicated to help improve blood sugar control in type 2 diabetes as an addition to diet and exercise. It is not for type 1 diabetes or diabetic ketoacidosis.
Does Invokamet cause weight loss?
Some people may have modest weight reduction with SGLT2 inhibitor therapy, but responses vary. Invokamet is not a weight-loss medicine, and any weight change should be considered alongside hydration, nutrition, and diabetes monitoring.
What side effects should I watch for with Invokamet?
Common effects include genital yeast infections, urinary tract infections, increased urination, thirst, nausea, diarrhea, stomach upset, headache, or dizziness. Seek urgent care for symptoms of ketoacidosis, lactic acidosis, severe dehydration, serious infection, or new foot wounds.
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