Janumet® Tablets for Type 2 Diabetes

Janumet is a prescription tablet that combines sitagliptin and metformin for adults with type 2 diabetes. It supports blood sugar control alongside diet and activity. With US shipping from Canada, this page helps you compare options and plan refills, even without insurance.

What Janumet Is and How It Works

Janumet® contains sitagliptin, a DPP-4 inhibitor, and metformin, a biguanide. The two work together to help your body manage glucose. Sitagliptin increases incretin activity, which may boost insulin release after meals and reduce glucagon. Metformin decreases hepatic glucose production and can improve insulin sensitivity.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine is used in adults with Type 2 Diabetes who need combination therapy. It is not for type 1 diabetes or diabetic ketoacidosis. Diabetes Care resources on our site can help you prepare for treatment discussions. Sitagliptin metformin Janumet may be considered when a single agent is not enough.

Who It’s For

This treatment is for adults with type 2 diabetes who need additional glucose control beyond metformin alone or another agent. It may be used when fasting and post-meal numbers remain above target despite lifestyle measures. People with significant kidney disease, metabolic acidosis, or a history of serious hypersensitivity to components should avoid it. Those with suspected pancreatitis should not restart until fully evaluated.

Review your history of heart failure, kidney function, alcohol use, and liver disease with a clinician. Share any prior lactic acidosis, pancreatitis, or severe joint pain. Discuss pregnancy and breastfeeding plans before starting therapy.

Dosage and Usage

Tablets are taken by mouth with meals. Immediate-release is typically taken twice daily with food to reduce stomach upset. Extended-release is usually taken once daily with the evening meal. Doses are individualized based on your current regimen and tolerability.

Do not crush or chew extended-release tablets. Swallow whole with water. If switching from separate sitagliptin and metformin tablets, your prescriber may match the nearest combined strength. When uncertain, follow the official product label and your clinician’s instructions.

General administration tips:

• Take with food to limit stomach discomfort.
• Stay hydrated, especially during illness or travel.
• If a procedure with iodinated contrast is planned, tell your prescriber in advance.

Strengths and Forms

Available as immediate-release tablets commonly published in 50/500 mg and 50/1000 mg strengths. Extended-release options exist; availability may vary by market and supplier.

Supply sources can include Canada and India; presentations vary by origin.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to the next scheduled dose. If it is almost time for your next dose, skip the missed tablet and resume your normal schedule. Do not double up to make up for a missed dose.

Storage and Travel Basics

Store tablets at room temperature in the original container, away from excess moisture and light. Keep the bottle tightly closed and out of reach of children and pets. For travel, carry your prescription label and a copy of your medication list. Use a pill organizer if advised, and keep tablets in your carry-on to avoid extreme temperatures. Some orders use temperature-controlled handling when required.

Benefits

This combination targets fasting and post-meal glucose through complementary mechanisms. It may simplify therapy by reducing pill burden compared with separate tablets. Many patients appreciate once-daily extended-release convenience. Pairing the treatment with nutrition, activity, and regular monitoring helps support long-term control.

Side Effects and Safety

Common effects include nausea, diarrhea, stomach upset, gas, headache, and mild upper respiratory symptoms. These often improve after dose stabilization or when taken with meals.

Serious but less common risks include lactic acidosis with metformin, pancreatitis with sitagliptin, severe joint pain, allergic reactions, and kidney issues. Stop the medicine and seek urgent care for severe abdominal pain, unusual muscle aches, profound weakness, shortness of breath, or allergic symptoms such as rash, swelling, or trouble breathing. Hypoglycemia can occur when used with insulin or a sulfonylurea; review prevention strategies with your prescriber. For broader context on insulin use, see Different Types Of Insulin.

Drug Interactions and Cautions

Tell your clinician about all medicines, vitamins, and supplements. Important considerations include:

• Iodinated contrast procedures: metformin may need temporary interruption.
• Renal impairment: dosing and monitoring may change.
• Excessive alcohol use: increases lactic acidosis risk.
• Cationic drugs eliminated by renal tubular secretion, like cimetidine: may affect metformin levels.
• Insulin or sulfonylureas: increased risk of low blood sugar; review signs and management.

Not for type 1 diabetes or diabetic ketoacidosis. Report liver disease, heart failure, or dehydration risk. See Insulin Resistance for lifestyle foundations that support therapy.

What to Expect Over Time

Glucose readings may improve when you take tablets as prescribed, paired with consistent meals and activity. You may see steadier fasting numbers and better post-meal trends. Your prescriber may adjust therapy based on A1C, tolerability, and kidney function.

Keep a log of readings, meals, and symptoms. Bring it to appointments to guide shared decisions. For background on long-term planning and goals, see Diabetes Reversal Facts.

Compare With Alternatives

Some patients start with a single agent and add a second medicine later. An alternative is Sitagliptin, typically paired with metformin separately. Another option is a sulfonylurea such as Glimepiride, which increases insulin release. Discuss how these classes fit your goals and risks. For an overview of many options, explore our Diabetes Drugs List.

Pricing and Access

Canadian-based supply can help you compare out-of-pocket costs. If you are tracking the Janumet price, use the product page to view current options by source and form. Many patients review Janumet Canadian pricing to understand potential savings compared with local cash rates. For coupon and offer updates, see our Promotions.

We arrange fulfilment with licensed partners and coordinate prescriber verification. Ships from Canada to US for eligible orders. Your final out-of-pocket amount depends on the selection, quantity, and verification outcome. We use encrypted checkout to help protect your information.

Availability and Substitutions

Supply can vary by strength and origin. If a requested option is unavailable, your prescriber may recommend a comparable alternative or adjust the plan. Janumet US shipping may differ by stock and source. We will notify you if your selection needs a change before processing.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who need dual action but prefer a single tablet regimen. It may not fit those with advanced kidney disease, prior lactic acidosis, or active pancreatitis concerns. Review your history and labs with your clinician before starting.

To reduce out-of-pocket impact, consider larger fills when appropriate, and schedule refills ahead of travel. Setting reminders can help maintain adherence. If you watch the Janumet cash price, compare sources and forms to identify a good fit for your budget. Category pages like Diabetes Care and origin filters such as Canada or India may offer alternatives that meet your prescriber’s plan.

Questions to Ask Your Clinician

• Is this combination appropriate for my A1C and kidney function?
• Should I use immediate-release or extended-release based on my symptoms?
• How should I monitor for low blood sugar with my other medicines?
• What signs of lactic acidosis or pancreatitis should I watch for?
• Do I need changes around imaging with contrast?
• How often should I repeat labs to monitor safety?

Authoritative Sources

• DailyMed: JANUMET Prescribing Information
• Manufacturer PI (Merck) for JANUMET
• Health Canada Drug Product Database

Ready to get started? Add your selection to cart for US delivery from Canada with prompt, express shipping. This page is informational and not a substitute for professional medical advice.