Jentadueto® Tablets for Type 2 Diabetes

This prescription combination tablet helps manage type 2 diabetes in adults. It pairs linagliptin with metformin to improve blood sugar alongside diet and activity. You can access US delivery from Canada here, and compare options even without insurance.

What Jentadueto Is and How It Works

Jentadueto® combines a DPP-4 inhibitor (linagliptin) with a biguanide (metformin). The DPP-4 inhibitor helps raise incretin levels, which can increase insulin release and lower glucagon when glucose is high. Metformin decreases hepatic glucose production and may improve insulin sensitivity in peripheral tissues. Together, this medicine supports day-to-day glucose control when used with a balanced plan.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This treatment is used as an adjunct to diet and exercise in adults with type 2 diabetes. It is not for type 1 diabetes or diabetic ketoacidosis. For broader context on therapies, see our Diabetes Drugs List and condition overview for Type 2 Diabetes.

Who It’s For

This combination is indicated to improve glycemic control in adults with type 2 diabetes mellitus. Clinicians may use it in people not controlled on metformin alone, or in those already taking both components separately.

It should not be used in people with severe renal impairment, metabolic acidosis, or a history of serious hypersensitivity to any component. Those with risk factors for lactic acidosis, such as advanced kidney disease or acute illness, should avoid metformin-containing products. People with a history of pancreatitis should discuss risks and symptoms with a healthcare professional. Individuals with heart failure should be monitored according to current guidance for DPP‑4 inhibitors.

Dosage and Usage

Use exactly as prescribed. Dosing is individualized based on current therapy and tolerability. If you are new to the combination, prescribers often start at a lower metformin amount and increase gradually to reduce stomach side effects. Swallow tablets whole with food. Taking the dose with the morning and evening meals can help stomach comfort for immediate‑release tablets. Extended‑release versions are usually taken once daily with an evening meal.

Do not crush or chew extended‑release tablets. Your clinician may adjust the regimen if you take insulin or a sulfonylurea, due to a higher risk of hypoglycemia when used together. Temporarily stop metformin-containing products around iodinated contrast imaging in certain patients and restart only after kidney function is re‑evaluated, as directed on the official label.

When uncertain about schedules or changes, defer to the approved prescribing information and your prescriber’s guidance.

Strengths and Forms

Film‑coated tablets are available in commonly published strengths, including Linagliptin metformin 2.5/500 mg and 2.5/1000 mg. Some markets also offer an extended‑release option that allows once‑daily dosing. Availability can vary by source and manufacturer. Your pharmacist will dispense the strength written on your prescription when in stock.

Missed Dose and Timing

If you miss a dose, take it when remembered unless it is almost time for the next scheduled dose. If it is close to the next dose, skip the missed dose and resume your regular schedule. Do not double up to make up for a missed tablet. Keeping a daily routine and meal‑time reminders can help you stay on track.

Storage and Travel Basics

Store tablets at room temperature in the original container with the lid closed. Keep away from moisture, excessive heat, and direct light. Always keep medicines out of reach of children and pets. For travel, carry your prescription‑labeled bottle in hand luggage. Pack an extra small supply and a copy of your prescription if possible. Some products may require temperature-controlled handling when required during transit; your pharmacist can advise based on the item shipped.

Benefits

This combination reduces pill burden by pairing two complementary agents in one tablet. It can provide steady glucose-lowering effects when used with diet and activity. Extended‑release options may offer once‑daily convenience, which can support adherence for some adults. The class generally has a low intrinsic risk of hypoglycemia when not combined with insulin or sulfonylureas.

Side Effects and Safety

• Stomach upset or diarrhea, especially at the start
• Nausea, vomiting, or abdominal discomfort
• Headache or nasopharyngitis
• Mild rash or itching
• Joint or muscle aches

Rare but serious risks include lactic acidosis with metformin, acute pancreatitis, severe skin reactions including bullous pemphigoid, hypersensitivity reactions, and kidney issues. Stop the medicine and seek urgent care if you develop severe abdominal pain, unexplained nausea and vomiting, profound weakness, shortness of breath, or a widespread blistering rash. Vitamin B12 levels may decrease during long‑term metformin use; periodic monitoring may be considered.

Drug Interactions and Cautions

Alcohol and carbonic anhydrase inhibitors can increase the risk of lactic acidosis with metformin. Iodinated contrast can temporarily affect kidney function; follow label guidance on holding the medicine around imaging. Insulin and sulfonylureas can increase hypoglycemia risk when used with this therapy. Certain inducers, such as rifampin, may reduce linagliptin exposure; clinicians may evaluate alternatives or monitor response. Review all prescriptions, OTC products, and supplements with your healthcare professional.

What to Expect Over Time

Many people notice gradual improvements in fasting and post‑meal readings when they take the tablets consistently with meals. Stomach symptoms often lessen after dose titration and steady use. Lifestyle measures remain essential; the combination works best alongside nutritious meals and regular activity. If your plan includes other agents, your team may adjust them to balance results and minimize low‑sugar episodes. For background on diet and medication roles, explore Treat Insulin Resistance and Can Type 2 Diabetes.

Compare With Alternatives

Other DPP‑4 approaches include sitagliptin, available alone or in fixed‑dose combinations. If a prescriber is considering a similar path, they might compare Sitagliptin with metformin‑based options. SGLT2 combinations, such as Invokamet, pair canagliflozin with metformin and are used for select patients. Choice depends on your medical history, lab results, and goals.

Pricing and Access

Canadian pharmacy pricing can help lower your Jentadueto price compared to typical cash rates in many settings. Add the item to your cart to view current availability and forms with US shipping from Canada. We support secure, encrypted checkout and provide clear options before you place your order. If you are looking for a discount, check whether a Jentadueto coupon is listed in our offers and see our Promotions. Explore related options in Diabetes Care and see items sourced from Canada.

Availability and Substitutions

Supply can vary by strength, pack size, and manufacturer. If an item is temporarily unavailable, your prescriber may recommend a suitable alternative or separate components. We reflect real‑time catalog updates online. Some customers ask about Jentadueto Canadian pricing; when options are listed, we show the current selection so you can compare.

Patient Suitability and Cost-Saving Tips

Good candidates are adults with type 2 diabetes needing more than diet and exercise alone, especially those not controlled on metformin by itself. People with severe kidney disease, active metabolic acidosis, or a history of serious reactions to the components should not use it. Those with pancreatitis history, hepatic disease, or heart failure require careful evaluation.

To manage costs, consider multi‑month supplies when appropriate, which can reduce per‑fill fees. Set refill reminders so you do not miss doses. Use available coupons or site offers to lower Jentadueto out of pocket costs when listed. For broader context on insulin use in combination plans, see Lantus Insulin Uses and seasonal education such as Diabetes Month 2025.

Questions to Ask Your Clinician

• Starting goals: what A1C and glucose targets fit my situation?
• Dosing plan: how will my schedule change from current therapy?
• Side effects: which symptoms should prompt a call or visit?
• Other medicines: do I need adjustments to insulin or sulfonylureas?
• Kidney and labs: how often will you check renal function and B12?
• Imaging: should I hold doses before contrast studies?
• Travel: how should I pack tablets and documentation for trips?

Authoritative Sources

FDA DailyMed

Boehringer Ingelheim

Health Canada DPD

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