Kazano

Uses of Kazano

Kazano 12.5/1000mg 56 Tablets is an oral medication that is prescribed for the treatment of type 2 diabetes. It contains two active ingredients, alogliptin and metformin, which work together to regulate blood sugar levels

Kazano is primarily used to help lower blood sugar levels and improve glycemic control in adults with type 2 diabetes. It is often prescribed alongside a healthy diet and exercise routine.

Alogliptin, one of the active ingredients in Kazano, inhibits the DPP-4 enzyme, which increases the levels of incretin hormones like GLP-1. This process helps to stimulate the release of insulin while reducing the production of glucose by the liver.

Metformin, the other active ingredient, also reduces glucose production in the liver while improving the body’s response to insulin. Additionally, it helps to lower the absorption of glucose from the intestines.

Together, these mechanisms of action assist in controlling blood sugar levels and improving glycemic control in individuals with type 2 diabetes.

Precautions and Warnings

You should not use Kazano if you are allergic to alogliptin or metformin, or if you have severe kidney disease or diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

• kidney disease;
• heart disease;
• liver disease;
• pancreatitis;
• gallstones; or
• alcoholism.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Kazano. Be sure your caregivers know ahead of time that you are using this medicine.

Follow your doctor’s instructions about using Kazano if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

It may not be safe to breastfeed while using Kazano. Ask your doctor about any risk.

This medicine may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

This medicine is not approved for use by anyone younger than 18 years old.

Dosage

The dosage of Kazano (alogliptin and metformin) varies depending on the individual’s medical condition, response to treatment, and existing diabetes management plan.

Usual Adult Dose of Kazano for Diabetes Type 2:
Initial dose: alogliptin 12.5 mg-metformin 500 mg OR alogliptin 12.5 mg-metformin 1000 mg orally twice a day
Maintenance dose: Adjust dose based on efficacy and tolerability
Maximum dose: alogliptin 25 mg-metformin 2000 mg per day

Side Effects

Common side effects

• diarrhea, upset stomach;
• increased blood pressure (severe headache, blurred vision, pounding in your neck or ears);
• back pain, headache; or
• cold symptoms such as stuffy nose, sinus pain, sore throat.

Serious side effects:

• unusual muscle pain;
• feeling cold;
• trouble breathing;
• feeling dizzy, light-headed, tired, or very weak;
• stomach pain, vomiting; or
• slow or irregular heart rate.