Lupron Depot® Injection for Prostate Cancer

Lupron Depot® is a prescription depot injection that suppresses hormone production for advanced prostate cancer. This page explains how it works, who it’s for, and how to use it safely. We provide US delivery from Canada and show the Lupron Depot price without insurance so you can plan your order.

What Lupron Depot Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine contains leuprolide acetate, a gonadotropin-releasing hormone (GnRH) agonist. It initially stimulates, then suppresses, pituitary release of LH and FSH. Over time, that lowers testosterone to castration levels, which can slow the growth of hormone-sensitive prostate cancer. In gynecologic conditions, the same mechanism reduces estrogen production to help control symptoms.

The treatment is supplied as a long-acting intramuscular depot. A clinician mixes and injects the suspension, where it releases medicine gradually over weeks to months. Your care team may monitor PSA or symptom changes as part of ongoing management.

Who It’s For

The injection is used in adults for palliative treatment of advanced prostate cancer. It can also be prescribed to manage endometriosis symptoms or to shrink uterine fibroids before surgery. Pediatric use includes central precocious puberty, guided by a specialist. See our condition guides for more context on Prostate Cancer, Endometriosis, and Uterine Fibroids.

People who should avoid this therapy include those with known hypersensitivity to GnRH, GnRH analogs, or any component of the product. It is not for use during pregnancy; fetal harm can occur. Breastfeeding requires clinician guidance. Use caution with a history of severe osteoporosis, uncontrolled depression, seizures, or significant heart rhythm problems.

Dosage and Usage

Administration is performed by a healthcare professional as a single intramuscular injection on a regular schedule. For prostate cancer, dosing is typically monthly or at longer intervals depending on the selected depot strength. Your prescriber sets the interval based on the labeled formulation and your treatment plan.

The Lupron Depot shot is prepared by reconstituting the powder immediately before use. It should be injected promptly after mixing. Do not self-inject unless explicitly trained and instructed. Keep all clinic appointments, as consistent timing helps maintain suppression.

If you transition between monthly and extended-interval depots, the next dose is given when the prior interval concludes. Your team may check PSA, testosterone, or symptom response to guide ongoing care. Always follow the official label and your prescriber’s instructions.

Strengths and Forms

This long-acting medicine is available as a powder-and-diluent kit for intramuscular injection. Availability can vary by pharmacy partner and market.

• Lupron Depot 3.75 mg: one-month depot formulation
• 22.5 mg: commonly used three-month depot

Your prescriber selects the presentation that suits your condition and visit cadence. Exact stock and packaging may differ; our team can clarify what is available at checkout.

Missed Dose and Timing

If a scheduled clinic injection is missed, contact your prescriber’s office to reschedule as soon as possible. Do not add extra doses. Because suppression depends on steady release from the depot, keeping a consistent schedule matters. If your symptoms worsen after a missed visit, notify your clinician for guidance.

Storage and Travel Basics

Storage is usually managed by the dispensing pharmacy or clinic. If you are asked to hold the kit before an appointment, keep it in the original carton at room temperature, away from heat, moisture, and direct light. Do not freeze. Store out of reach of children and pets.

For travel to an injection visit, carry the labeled carton and your prescription details. Avoid leaving the kit in a parked car. If your itinerary involves inspection, pack documentation in your hand luggage. When uncertain, follow the patient information leaflet or contact your clinic for instructions.

Benefits

This therapy reduces testosterone to help control signs and symptoms of advanced prostate cancer. Patients may experience relief from bone pain or urinary symptoms as part of a broader plan. Extended-interval depots can reduce the number of office visits compared to monthly dosing. For gynecologic conditions, lowering estrogen may lessen pelvic pain and bleeding.

Because the depot is administered by clinicians, dosing accuracy and adherence are supported by scheduled visits. That structure can simplify routines for some patients. Your care team will monitor response and safety, adjusting the plan when needed.

Side Effects and Safety

• Hot flashes and sweating
• Injection site pain, redness, or bruising
• Headache or dizziness
• Fatigue and trouble sleeping
• Mood changes, irritability, or depressed mood
• Decreased libido and erectile dysfunction
• Joint or muscle aches

Serious effects are less common but can occur. Early in therapy, a temporary hormone “flare” may worsen pain or urinary symptoms; clinicians may use additional medicines to manage this risk. Long-term hormone suppression can reduce bone mineral density. Rare events include pituitary apoplexy shortly after the first dose, allergic reactions, and QT prolongation, especially with other QT-prolonging drugs. People with diabetes may see changes in glucose control. Seek urgent help for chest pain, severe headache, fainting, or signs of an allergic reaction.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements. Use caution with other therapies that prolong the QT interval, certain antiarrhythmics, and some antibiotics. Hormonal agents can complicate interpretation of response. Alcohol and sedatives may worsen dizziness or mood changes. If you use diabetes medicines, your prescriber may increase monitoring while on androgen-deprivation therapy.

What to Expect Over Time

During the first couple of weeks, some people notice transient symptom flare as hormones briefly rise before suppression. As therapy continues, testosterone typically falls to castration levels, and PSA may decline for many patients. Your experience varies based on disease characteristics and the overall plan, which may include additional agents. Keeping injection appointments and reporting new symptoms helps your team tailor care. For more educational reading, see our article on Prostate Health.

Compare With Alternatives

Other androgen-deprivation options include GnRH antagonists and oral agents. Degarelix offers rapid suppression without initial flare but requires maintenance injections. Oral relugolix can be an option when daily tablets fit your routine. Additional systemic treatments, such as androgen receptor inhibitors or CYP17 inhibitors, are often combined with hormone suppression based on stage and risk.

We also carry approved options such as Orgovyx and Zytiga. Your oncology team will decide whether any of these belong in your plan.

Pricing and Access

Canadian pricing with US shipping from Canada helps many patients manage therapy costs. You can review current formulations and the Lupron Depot price on our product page, then submit your prescription for verification. We support encrypted checkout and transparent steps from upload to fulfilment.

Looking for savings? Check limited-time offers on our Promotions page. If your prescriber chooses an extended-interval depot, fewer clinic visits may lower ancillary expenses. You can also compare options sourced from Canada to understand potential cash-pay differences.

Availability and Substitutions

Supply can vary by strength or packaging. If a specific depot is unavailable, a prescriber may recommend an alternative formulation or a different GnRH agent. The pharmacy team can coordinate with your clinician to clarify equivalent intervals and timing. We do not promise restock dates but will help you navigate options supported by labeling.

Patient Suitability and Cost-Saving Tips

This therapy may be appropriate for adults with hormone-sensitive prostate cancer, and for certain gynecologic indications, when benefits outweigh risks. It may not suit people with severe osteoporosis unless the bone risks are managed. Discuss mental health history and heart rhythm concerns before starting.

Cost-saving ideas include multi-month depot choices when medically appropriate, calendar reminders for appointments, and consolidating lab draws with clinic visits. Ask your prescriber about coordinating injections with other scheduled care to reduce travel. For cash-pay users, compare extended-interval depots to minimize visit-related expenses. Set refill reminders so your next clinic dose aligns smoothly with the prior interval.

Questions to Ask Your Clinician

• Which depot interval best fits my diagnosis and schedule?
• How will you manage the initial flare risk, if relevant to my case?
• What monitoring will we use for PSA, testosterone, or symptoms?
• How should I protect bone health during long-term suppression?
• Could any of my current medicines raise heart rhythm concerns?
• What side effects should prompt an urgent call?
• If supply changes, what equivalent options are available?

Authoritative Sources

FDA DailyMed | Health Canada DPD | Manufacturer

Ready to proceed? You can place your order with prompt, express shipping — Ships from Canada to US. Always follow your prescriber’s guidance; this page is educational and not a substitute for professional medical advice.