Myfembree® Tablets for Uterine Fibroids and Endometriosis

Myfembree is a prescription tablet used to manage heavy menstrual bleeding from fibroids and pain from endometriosis. This page explains how it works, who it’s for, dosing, and safety so you can compare options and plan care, with US delivery from Canada and guidance on paying without insurance.

What Myfembree Is and How It Works

Myfembree® combines three ingredients: relugolix, estradiol, and norethindrone acetate. The regimen lowers ovarian hormone signaling while replacing a small amount of estrogen and progestin to help control bleeding and pain. It is a gonadotropin-releasing hormone (GnRH) antagonist paired with add-back therapy. This approach may reduce heavy periods in fibroids and ease pelvic pain from endometriosis.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Myfembree for endometriosis and fibroid-related bleeding is FDA-approved for appropriate adults. The active antagonist, relugolix, quickly lowers luteinizing hormone and follicle-stimulating hormone. Add-back estradiol and norethindrone help protect bone and reduce hot flashes compared with antagonist therapy alone. Always review the Patient Information and talk with your clinician before starting.

We cover label-based dosing, common effects, and what to discuss with your prescriber. You will also find access tips and alternatives if this therapy is not suitable.

Who It’s For

This medicine is indicated for treatment of heavy menstrual bleeding associated with uterine fibroids in premenopausal adults. It is also indicated to manage moderate to severe endometriosis pain in the same population. It is not a contraceptive. Patients should use effective nonhormonal birth control during treatment and for a time after the last dose per the official label.

People with a history of thromboembolic disorders, stroke, certain heart conditions, uncontrolled hypertension, known osteoporosis, hormone-sensitive cancers, or severe liver disease should avoid this therapy. Do not use during pregnancy. A pregnancy test is typically recommended before starting, and if pregnancy is suspected later. Smoking increases cardiovascular risk with estrogen-containing therapies, especially for those over 35. Review individual risks with your healthcare professional.

Learn more about the conditions it treats here: Uterine Fibroids and Endometriosis. You can also browse broader topics in Women’s Health.

Dosage and Usage

The usual schedule is one tablet by mouth once daily at about the same time each day. Swallow the tablet whole with water. You can take it with or without food. Starting within seven days of the onset of menses is commonly recommended on the label to reduce the chance of early bleeding irregularities. If you switch from certain hormonal therapies, your prescriber will advise on timing.

Myfembree dosage remains one tablet daily throughout treatment. Do not split, crush, or chew tablets. If you vomit shortly after dosing, follow label guidance or contact your prescriber for advice. Therapy duration is limited due to effects on bone mineral density; clinicians often reassess benefit and risk during use.

Always follow the official labeling and your prescriber’s instructions. Do not make changes to your regimen without clinical guidance.

Strengths and Forms

This combination comes as film-coated oral tablets in unit-of-use packaging. A common presentation provides relugolix 40 mg with estradiol 1 mg and norethindrone acetate 0.5 mg per tablet. Packaging may include calendar blisters to support consistent daily dosing. Availability can vary by jurisdiction and by partner pharmacy.

Many references describe the class using the term Relugolix Estradiol Norethindrone tablets. Your prescription will specify the exact product supplied.

Missed Dose and Timing

If you miss a dose and remember within about 12 hours, take it as soon as you remember that day. If more time has passed, skip the missed tablet and take the next dose at the usual time the following day. Do not take two tablets at once to make up a missed dose. Try setting reminders or pairing dosing with a daily routine to improve consistency.

Storage and Travel Basics

Store tablets at room temperature in the original package to protect from moisture and light. Keep out of reach of children and pets. Do not use tablets that are damaged or past the labeled expiration date. When traveling, keep the medicine in your carry-on, along with a copy of your prescription and your prescriber’s contact information. A simple weekly pill case can help organize doses, but keep part of the box or leaflet for identification. If crossing borders, declare personal medications as required by local authorities.

Benefits

This treatment can reduce heavy menstrual bleeding linked to uterine fibroids. It can also lessen endometriosis-related pain, including menstrual cramps and pelvic discomfort between periods. Once-daily oral dosing may be more convenient than injections or procedures for some patients. The add-back hormones may help improve tolerability compared with antagonist therapy without add-back.

Many people value a predictable schedule and the potential for fewer missed activities due to bleeding or pain. Your experience can vary. Regular follow-up with your healthcare professional helps ensure benefits continue to outweigh risks.

Side Effects and Safety

Common effects may include hot flashes, headache, mood changes, fatigue, nausea, abdominal pain, and changes in bleeding patterns. Some people report decreased libido or mild weight change. These effects often improve with time, but any persistent or bothersome symptoms should be discussed with a clinician.

Myfembree side effects can also include more serious risks. Estrogen/progestin components may increase the risk of blood clots, stroke, or heart attack, especially with additional risk factors. The antagonist component can lead to bone mineral density loss over time; clinicians may monitor bone health. New or worsening depression, abnormal liver tests, high blood pressure, and rare allergic reactions can occur. Seek urgent care for chest pain, shortness of breath, severe headache, vision changes, or swelling in a leg.

This therapy is contraindicated in pregnancy. Stop the medicine and contact your prescriber if pregnancy is suspected. Refer to the Medication Guide for full safety details.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements you take. Strong or moderate CYP3A inducers may lower relugolix exposure and reduce effectiveness. Certain P-gp inhibitors can raise exposure; if unavoidable, label guidance may include timing separation. Avoid concurrent hormonal contraceptives unless your prescriber determines otherwise, because extra estrogen or progestin may change the balance of therapy.

Alcohol, nicotine, and uncontrolled blood pressure can add cardiovascular risk with estrogen-containing therapies. A history of fractures or osteoporosis warrants particular caution due to bone effects. Review the full Myfembree prescribing information for complete interaction details and contraindications.

What to Expect Over Time

Many patients notice gradual improvement in bleeding or pain after they establish a steady dosing routine. Patterns vary, and early cycle changes can happen. Regular use is important for consistent hormone suppression. Your clinician may assess symptoms, blood pressure, mood, and bone health at intervals. If benefits plateau or risks increase, your prescriber may suggest a different approach.

Discuss how the therapy fits with your goals for fertility, contraception, or potential procedures. Keep a simple symptom diary to track bleeding days and pain scores. Bring it to appointments to support shared decisions.

Compare With Alternatives

Other options exist if this regimen is not suitable. Progestin-focused therapy such as Dienogest is used in many regions for endometriosis pain and may be considered by prescribers when appropriate. Some clinicians also use combined hormonal regimens for cycle control; one example is Nextstellis, which contains estetrol and drospirenone. These therapies differ in composition, risks, and monitoring needs.

Surgical and procedural options, such as uterine-sparing approaches for fibroids, may also be discussed. Choice depends on your symptoms, plans for pregnancy, other health conditions, and response to prior treatments. Review options with your healthcare professional.

Pricing and Access

We provide Canadian pricing for this therapy with careful US fulfilment. You can compare options, review current availability, and see the cost of Myfembree relative to typical cash-pay ranges. If you’re seeking a Myfembree coupon, check our current offers on the Promotions page. Access is prescription-based, and our site supports encrypted checkout for your security.

Orders Ships from Canada to US, letting you consider cross-border options alongside local quotes. Your prescriber can send a script directly, or you can upload it during checkout. For broader topics, you can explore our Canada sourcing page to learn how items are sourced.

Availability and Substitutions

Supply can vary by manufacturer and packaging. If this medicine is temporarily unavailable, your prescriber may suggest a medically appropriate alternative. We cannot guarantee restock dates. Your clinician will decide if switching therapies is reasonable based on your history and goals.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults with significant bleeding due to fibroids or with moderate to severe endometriosis pain who prefer a once-daily tablet. It may not be appropriate if you have high clotting risk, uncontrolled blood pressure, severe liver disease, or established osteoporosis. Your healthcare professional will weigh benefits and risks given your history.

To manage costs, consider multi-month fills when appropriate, which can lower per-fill fees and reduce missed doses. Set refill reminders a week before running out. Compare your out-of-pocket estimates against any available patient support from your clinic. If paying cash, look at invoice details to understand cash price components. Canadian pricing can be favorable for some budgets, especially when planning longer courses.

Questions to Ask Your Clinician

• Is this therapy appropriate for my bleeding pattern or pain level?
• How long should I stay on treatment before reassessment?
• What are my risks based on age, smoking status, or blood pressure?
• How will we monitor bone mineral density during use?
• Which symptoms should prompt a call or urgent care visit?
• Could a progestin-only or combined hormonal alternative be better?
• How should I handle potential drug interactions with my current medicines?

Authoritative Sources

FDA DailyMed: Myfembree Prescribing Information

Manufacturer: Product Information

Health Canada Drug Product Database

Learn More

You can read related topics such as Menstruation And Migraines and What Is Hirsutism for broader context on hormonal health.

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