Pifeltro® Tablets for HIV-1

This medicine is a non-nucleoside reverse transcriptase inhibitor used with other HIV medicines. It helps lower viral load as part of a complete regimen. We offer US delivery from Canada, and options exist if you pay without insurance.

What Pifeltro Is and How It Works

Pifeltro® contains doravirine, an NNRTI used to treat HIV-1 infection. It blocks the reverse transcriptase enzyme, which the virus needs to replicate. The treatment is taken with other antiretrovirals to build a full regimen and support durable viral suppression. You can explore the broader HIV care context while planning your regimen with your prescriber.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine can be taken with or without food. It is not for monotherapy or HIV prevention. When used consistently, it may help reduce viral load and support immune recovery as measured by CD4 counts, guided by your care team.

Who It’s For

This treatment is indicated for adults and for pediatric patients who meet weight thresholds as described on the official label. It is used in combination with other antiretroviral medicines. People with known hypersensitivity to any component should avoid it. Those taking strong enzyme inducers should discuss alternatives, because some drugs can lower blood levels of this therapy. Individuals with significant liver disease need careful evaluation by a clinician before starting therapy. Breastfeeding is generally not recommended in the context of HIV.

Dosage and Usage

The standard schedule for doravirine is once daily, taken consistently at the same time each day. Some partner medicines have food requirements, so follow your full regimen’s label instructions. If you also take rifabutin or other inducers, the label may outline a different schedule; your prescriber will determine the plan.

Patients start this therapy as part of a complete regimen. Swallow tablets whole with water. Keep a daily routine, and set reminders if needed. Do not change your dose or stop treatment without medical guidance. Review the official label for the specific instructions that apply to doravirine 100 mg tablets in combination therapy.

Strengths and Forms

Available as Pifeltro 100 mg tablets. Pack sizes and packaging may vary by supplier. The medicine also exists in a fixed-dose combination with other agents under a separate brand; your prescriber may consider that option if appropriate. Availability can differ by partner pharmacy and timing.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember the same day. If it is almost time for the next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once. If vomiting occurs soon after a dose, follow label guidance or ask your prescriber or pharmacist for instructions.

Storage and Travel Basics

Store tablets at room temperature and protect them from moisture. Keep them in the original container with the desiccant and close the cap tightly. Keep out of reach of children and pets. Do not store in the bathroom or near sinks.

When you travel, pack your medicine in your carry-on. Keep the pharmacy label with your name and dose visible. Bring enough supply for the trip plus a buffer. Time zone changes may affect scheduling; a simple reminder app helps you stay consistent. If you use a pill organizer, keep the original labeled bottle for security checks and refills. We use encrypted checkout, and temperature-controlled handling when required.

Benefits

This NNRTI class option is taken once daily and can be used with or without food. It is generally well tolerated compared with some older non-nucleoside agents. The regimen flexibility helps your prescriber tailor a background of nucleoside and integrase or protease agents to your needs. Consistent use can support viral suppression as part of comprehensive HIV care.

Side Effects and Safety

• Headache
• Nausea
• Dizziness
• Tiredness
• Diarrhea
• Abdominal discomfort
• Abnormal dreams or sleep changes
• Rash

Serious reactions are uncommon but can include severe skin reactions or liver problems. Immune reconstitution syndrome may occur as your body responds to effective therapy. People with hepatitis B or C should be monitored. Seek urgent care for signs of severe rash, yellowing of the skin or eyes, dark urine, severe abdominal pain, or swelling of the face or throat.

Drug Interactions and Cautions

Strong CYP3A inducers can substantially reduce drug levels. This includes rifampin, carbamazepine, oxcarbazepine, phenytoin, phenobarbital, enzalutamide, mitotane, and St. John’s wort. Rifabutin is a moderate inducer and may require a modified schedule per label. Review all medicines, supplements, and herbal products with your prescriber and pharmacist. Use caution with significant hepatic impairment. This therapy is not for HIV pre-exposure prophylaxis.

What to Expect Over Time

With steady daily use and a complete background regimen, viral load may decrease over time. Your care team will monitor labs and assess for side effects. Many patients find once-daily scheduling easier to maintain. Building habits, like linking your dose to a daily routine, can support adherence. If your treatment plan changes, your prescriber will guide any adjustments.

Compare With Alternatives

Some patients may use the doravirine-based fixed-dose combination Delstrigo when appropriate. Others may use protease inhibitor–based regimens such as Kaletra Oral Solution in specific clinical contexts. Your prescriber will match agents to your resistance profile, comorbidities, and co-medications. To learn more about testing and regimen choice, see our guides on Types Of HIV Tests and common symptom patterns in HIV AIDS Symptoms.

Pricing and Access

Our marketplace highlights Canadian options with transparent information for U.S. patients. If you are comparing the Pifeltro price, you can view current offers and see how it fits your budget. We also publish details for doravirine cost where available so you can compare therapies across the class.

Orders include US shipping from Canada after your prescription is verified. You can browse related categories like Antivirals and origin information via Country Of Origin Canada. If you have a coupon, see Promotions for current notices.

Availability and Substitutions

Supply can vary. If this item is temporarily unavailable, a prescriber may recommend an alternative NNRTI regimen or a different drug class suited to your history. If you are comparing doravirine price with other options, consider the full regimen components, interaction profile, and your monitoring plan.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who need a non-nucleoside as part of a full regimen and who are not taking strong inducers. It is not a fit for those with hypersensitivity to components or for HIV prevention. Ask your prescriber about multi-month fills to reduce pharmacy trips. You can set refill reminders in your account so you do not run out during travel. Consider background agents with generic availability to help manage overall regimen costs. For broader context on treatment selection, review Biktarvy Guide, and for awareness initiatives see National HIV Testing Day and the overview Aptivus For HIV.

Questions to Ask Your Clinician

• Regimen fit: How does this NNRTI complement my current background agents?
• Interactions review: Are any of my medicines strong CYP3A inducers?
• Monitoring plan: Which labs and follow-up schedule should I expect?
• Side effects: What symptoms should prompt a call or visit?
• Resistance history: Do my prior results support use of this therapy?
• Adherence support: What reminders or tools can help me take doses daily?

Authoritative Sources

• Manufacturer Prescribing Information
• FDA DailyMed
• Health Canada DPD

Ready when your prescriber approves? You can buy Pifeltro online with prompt, express shipping and US shipping from Canada. This content is educational and not a substitute for professional medical advice.