Praluent® Injection for High Cholesterol

Praluent® is a PCSK9 inhibitor injection used with diet and statins to lower LDL cholesterol in certain adults. This page explains how it works, who it may suit, and how to handle dosing, storage, and access, with US delivery from Canada to simplify your options. If you want to compare Praluent price without insurance, you can review key considerations below.

What Praluent Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Praluent® contains alirocumab, a monoclonal antibody targeting PCSK9. By blocking PCSK9, it helps your liver remove more LDL particles from the bloodstream. The treatment is used alongside diet and maximally tolerated statin therapy in adults who need additional LDL reduction. It is studied in people with High Cholesterol, including those with clinical Atherosclerotic Cardiovascular Disease and certain inherited conditions like Familial Hypercholesterolemia.

It is given by subcutaneous injection using a ready-to-use pen or prefilled syringe. You or a caregiver can administer it after proper training. The mechanism is complementary to statins and other lipid-lowering therapies. Your clinician may combine therapies based on your LDL targets and medical history.

Who It’s For

This medicine is indicated for adults with clinical ASCVD or heterozygous familial hypercholesterolemia who require additional LDL-C lowering despite diet and statin therapy. It is not indicated for homozygous familial hypercholesterolemia. People with a history of serious hypersensitivity to alirocumab or any component should not use it.

Discuss your medical history before starting. Tell your prescriber about past allergic reactions, immune conditions, pregnancy or plans to become pregnant, and breastfeeding. Pediatric use is not established. If you have questions about alternatives within Cardiovascular care, your healthcare professional can guide you.

Dosage and Usage

Typical starting dose is 75 mg injected subcutaneously every 2 weeks. Your prescriber may adjust to 150 mg every 2 weeks if additional LDL lowering is needed. Some adults may use 300 mg every 4 weeks, administered as two 150 mg injections in a row at different sites.

Inject into the thigh, abdomen, or upper arm (upper arm only if a caregiver injects). Rotate injection sites with each dose. Do not inject into areas that are tender, bruised, or scarred. Allow the pen to reach room temperature out of the refrigerator before use; do not heat the device. Review the full Instructions for Use and ask your clinician or pharmacist for training if you are new to self-injection.

If you use other lipid-lowering medicines, your clinician may time labs to evaluate your response. Avoid changing dose or schedule without guidance. Refer to the official label for complete directions.

Strengths and Forms

Common presentations include single-use prefilled pens and prefilled syringes. Availability may vary by partner pharmacy.

• Praluent 75 mg ml pen
• 150 mg/mL prefilled presentation

Your prescriber will select a schedule and presentation that supports your treatment plan.

Missed Dose and Timing

If you miss a dose on an every-2-weeks schedule, take it as soon as you remember within 7 days and then return to your usual day. If more than 7 days have passed, skip the missed dose and take the next dose on your original day. For the every-4-weeks schedule, take a late dose as soon as you remember and consult the label or your clinician about when to resume monthly dosing. Do not take two full doses on the same day to make up for a missed dose.

Storage and Travel Basics

Store in the refrigerator in the original carton to protect from light. Do not freeze or shake. When you are ready to use a dose, allow the device to warm to room temperature as directed in the Instructions for Use. If permitted by the label, you may keep the device at room temperature for a limited window; discard if it exceeds the allowed time out of refrigeration.

For trips, keep the medicine insulated and away from extreme temperatures. Use a travel cooler with ice packs and avoid placing the device directly on ice. Pack a copy of your prescription and injection supplies in your carry-on. Keep out of reach of children. As a micro trust cue, we support temperature-controlled handling when required.

Pen Handling and Sharps Disposal

Before injecting, inspect the solution through the viewing window; do not use if discolored or contains particles. Follow the step-by-step Instructions for Use for priming (if required), skin preparation, and injection technique. After use, place the pen or syringe in an FDA-cleared sharps disposal container. Do not recap the needle. If you do not have a sharps container, use a heavy-duty household container with a tight-fitting, puncture-resistant lid and follow local regulations for disposal.

Benefits

This class can provide meaningful LDL-C reductions when used with diet and appropriate background therapy. It may be suitable for adults who need more LDL lowering than a statin alone provides, or for those who cannot tolerate higher statin doses. The treatment is given every 2 weeks or every 4 weeks, which many patients find practical. Praluent can be used alongside other therapies like Rosuvastatin Calcium, Atorvastatin 90 Tablets, or Fenofibrate when directed by your clinician.

Side Effects and Safety

• Injection-site reactions such as redness, itching, or swelling
• Cold or flu-like symptoms
• Nasopharyngitis or upper respiratory symptoms
• Muscle or joint pain
• General fatigue

Serious hypersensitivity reactions can occur, including rash, urticaria, or rare angioedema. Stop the medicine and seek care if you develop signs of a serious allergic reaction. Report any persistent injection-site issues. If you use insulin or sulfonylureas, this therapy does not typically increase hypoglycemia risk on its own, but your overall care plan should be reviewed by your clinician.

Drug Interactions and Cautions

Alirocumab is a monoclonal antibody broken down by protein pathways rather than liver enzymes, so clinically significant CYP-based interactions are unlikely. Always share your full medication and supplement list with your prescriber. Tell your clinician about any immune-modulating therapies, and any history of severe allergies. Review the label regarding device components and potential sensitivity to rubber materials.

If you are pregnant or breastfeeding, discuss risks and benefits. Your clinician will consider your cardiovascular risk and other options. Do not change other lipid therapies without medical guidance.

What to Expect Over Time

LDL-C reductions may be observed after consistent use along with diet and background therapy. Your clinician may order lipid panels after initiation and with dose changes to assess response. Many people appreciate the predictable schedule and at-home administration. Set reminders, rotate injection sites, and store the device properly to support steady use. If your goals are not met, your prescriber may adjust the dose or consider an alternative from the same or a different class.

Heart-healthy habits, including diet and activity, remain important. For broader reading, see our article on Wegovy And Its Impact on lipid profiles and cardiometabolic health. You can also review our country-of-origin detail for select items from Canada.

Compare With Alternatives

Two other LDL-lowering injectables are commonly used:

• Repatha® (evolocumab), another PCSK9 inhibitor with similar indications
• Leqvio® (inclisiran), an siRNA that reduces PCSK9 production with infrequent dosing after the initial phase

Your prescriber may compare profiles, dosing schedules, and your clinical goals to choose the best fit.

Pricing and Access

We highlight transparent options so you can discuss value with your prescriber. If you are evaluating Praluent injection cost, it helps to compare background therapy needs, dosing frequency, and monitoring. Many adults also review Praluent price from Canada to understand potential savings with US shipping from Canada. If you are looking for coupons, check current offers on our Promotions page.

For those paying cash, you can browse listings and determine if Canadian pricing aligns with your care plan. You may also see savings discussions for non-oral cardiovascular therapies within our condition pages. When comparing options without insurance, your clinician can help weigh schedule, device preference, and lab follow-up needs along with budget.

Availability and Substitutions

Stock can vary by partner pharmacy. If a specific presentation is not available, your prescriber may recommend a comparable alternative in the same class or another lipid-lowering option. For questions about timing and fulfilment, you can check details for Praluent US shipping on the product page. We do not list restock dates; please check back or speak with your clinician about alternatives if needed.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults who need substantial LDL-C reduction beyond what a statin alone provides. It may also be considered for adults who cannot tolerate higher doses of statins. People with known hypersensitivity to alirocumab should not use it. Discuss your medical history in detail before starting any new lipid-lowering therapy.

To manage budget, ask about multi-month supplies when appropriate, and set refill reminders to avoid gaps. Compare your insurance benefit against Canadian pricing to find a workable option. Some patients review Praluent cash price alongside statins or add-on oral agents to plan a sustainable regimen. Keep documentation handy if you travel, and coordinate lab visits so results support any cost discussions with your prescriber.

Questions to Ask Your Clinician

• LDL targets: What LDL-C level are we aiming for, and how will we measure progress?
• Dose plan: Should we start every 2 weeks or monthly, and when might adjustments be considered?
• Combination therapy: Which statins or non-statin agents should stay in my plan?
• Self-injection: Can you review pen technique, injection sites, and disposal?
• Monitoring: When will lipid panels be checked after starting and after any change?
• Safety: What allergic reaction symptoms should I watch for, and what should I do?
• Travel: How should I store and pack the pen to keep it within the allowed temperature window?

Authoritative Sources

Ready to proceed? You can add to cart and choose fulfilment that Ships from Canada to US with prompt, express shipping. This information is not a substitute for medical advice. Always follow your prescriber’s guidance and the official label.