Prasugrel

Uses of Prasugrel

Precautions and Warning

Who should not use prasugrel?

People who are allergic to any of the following should not take prasugrel. Your pharmacist can tell you all of the ingredients in the specific prasugrel products they stock. People who are bleeding should not take prasugrel. This includes, for example, stomach ulcers that are bleeding and intracranial (brain) bleeding. Intracranial bleeding is a type of stroke, which would be managed by emergency personnel.  People who have had a stroke or transient ischemic attack (TIA), sometimes called a mini stroke, should not take prasugrel. Do not share prasugrel with other people, even if they have the same condition as you. It may harm them. Keep prasugrel out of the reach of children. Do not break the tablet. Do not stop taking prasugrel without first discussing it with the healthcare provider who prescribed it. Tell all healthcare providers that you are taking prasugrel before they perform any procedure or surgery that may cause bleeding. Tell all healthcare providers to contact the healthcare provider who prescribed prasugrel before stopping this medicine. Tell your healthcare provider right away if you fall or have any injuries, especially if you injure your head. People who weigh less than 132 pounds (60 kg) can be at greater risk for some side effects from prasugrel. Talk to your healthcare provider about your risks if you fall into this weight category. People who are 75 or older can be at greater risk for some side effects from prasugrel. Talk to your healthcare provider about your risks if you are in this age group. It is not known if or how prasugrel could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.  It is not known if prasugrel passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take prasugrel while breastfeeding.

Dosage

Usual Adult Dose for Acute Coronary Syndrome: Initial dose: 60 mg orally once Maintenance dose: 10 mg orally once a day

Usual Geriatric Dose for Acute Coronary Syndrome: 65 to less than 75 years: -Initial dose: 60 mg orally once -Maintenance dose: 10 mg orally once a day

Side Effects

Common Side Effects:

• nosebleeds; or
• easy bruising or bleeding.

Serious Side Effects:

• a light-headed feeling, like you might pass out;
• any bleeding that will not stop;
• pink or brown urine;
• signs of a serious blood-clotting problem–pale skin, purple spots under your skin or on your mouth, fever, fast heart rate, weakness, stomach pain, trouble breathing, jaundice (yellowing of the skin or eyes);
• signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
• signs of a stroke–sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.