ProHeart 6® Injection for Dogs

ProHeart 6 is a veterinarian-administered injection that helps protect dogs from heartworm disease. This page explains how it works, who it may suit, and how you can arrange access, including options for those without insurance. Ships from Canada to US.

What ProHeart 6 Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Heartworm Disease places dogs at risk for serious lung and heart complications. ProHeart 6® is a sustained-release formulation of moxidectin, a macrocyclic lactone that targets heartworm larvae transmitted by mosquitoes. After a single ProHeart 6 injection, microcapsules slowly release medicine under the skin. This extended release maintains protective levels for six months, reducing gaps that can occur with missed monthly dosing. The treatment also addresses certain intestinal hookworm infections as stated on the label.

Because it is administered by a veterinary professional, dosing accuracy and in-clinic observation help support safe use. Dogs should be healthy and heartworm-negative before receiving the injection. A discussion with a veterinarian helps determine suitability based on age, health status, and any prior reactions.

Who It’s For

This long-acting prevention is indicated for dogs to prevent heartworm disease for six months. It is also labeled for the treatment of susceptible hookworm infections. The phrase ProHeart 6 for dogs reflects that the product is intended only for canine use and is not for other species. Dogs should be at least the labeled minimum age per official instructions.

It may not be appropriate for dogs with a history of hypersensitivity to moxidectin or those with previous reactions to injectable preventives. Use caution in dogs with underlying illness, weight loss, or unstable conditions. Pregnant or lactating animals require veterinarian guidance. Always ensure a negative heartworm test before the appointment.

Dosage and Usage

This therapy is given as a single subcutaneous dose by a veterinarian, then repeated every six months. The dose is weight-based under the official label. The phrase 6 month heartworm injection describes the intended duration of protection under labeled conditions. The clinic will reconstitute the vial immediately before use and inject under the skin, typically over the back.

Before each appointment, a heartworm test is recommended to confirm negative status. Dogs on the injection should also use separate flea and tick preventives if needed, since this treatment does not cover those parasites. If a dose window is missed, the veterinarian will advise on testing and the next administration date. Always follow the label and clinic protocols.

Strengths and Forms

This product is supplied as a lyophilized microsphere vial with a sterile diluent for reconstitution, resulting in a long-acting injectable suspension. The exact concentration and presentation are defined in the official labeling and may vary by market. The kit is designed for single-dose use per weight and must be prepared and administered by a veterinary professional.

The descriptor ProHeart 6 moxidectin emphasizes the active ingredient and 6-month duration, which differentiates it from monthly preventives and from the 12-month formulation available in some regions. Availability can vary; clinics may stock different pack sizes.

Missed Dose and Timing

If a scheduled injection is delayed, a veterinarian may recommend heartworm testing and then administer the next dose. Dogs should remain on a six-month cycle after the clinic visit. Using the term 6 month heartworm shot is a reminder of the intended interval; however, only a veterinary professional should determine the timing based on testing and label guidance.

Do not attempt home injection. Keep clinic reminders active to maintain continuity of protection. If a dog travels to regions with higher mosquito exposure, discuss timing and testing with the veterinarian.

Storage and Travel Basics

This is a clinic medicine, not intended for home storage. Veterinary teams store and prepare it according to the label. If you need to transport a sealed kit between licensed facilities at a prescriber’s direction, keep it upright, protected from direct heat and light, and do not freeze. Follow any packaging instructions provided by the clinic.

When traveling with a pet, carry documentation of recent heartworm testing and preventive history. Clinics can update records and schedule the next dose at the destination if needed. For site checkout and account management, Border Free Health uses encrypted checkout; clinics handle storage and handling. Some items involve temperature-controlled handling when required.

Benefits

Long-acting prevention can reduce missed doses that occur with monthly schedules. One clinic visit covers six months, simplifying adherence for busy households. The injection works continuously in the background, which may be convenient for dogs who resist oral tablets or for families who prefer fewer at-home doses.

Labeling also addresses intestinal parasites in dogs; the phrase ProHeart 6 hookworms highlights this labeled indication. Consistent prevention decreases the risk of heartworm disease, which is difficult and costly to treat once established. Annual testing remains important, even when using long-acting prevention.

Side Effects and Safety

• Digestive changes: vomiting, diarrhea, or decreased appetite
• Behavior changes: lethargy or restlessness
• Skin reactions: itching, hives, or swelling at the injection site
• Neurologic signs: tremors or seizures in rare cases

Serious hypersensitivity reactions have been reported. If a dog develops facial swelling, collapse, or trouble breathing, veterinarians may treat with antihistamines, corticosteroids, or supportive care. Dogs with known sensitivity to macrocyclic lactones or with a previous adverse event to this class may not be good candidates. Discuss prior medical history, current medicines, and recent vaccines with the veterinary team before the visit.

Drug Interactions and Cautions

Moxidectin is a macrocyclic lactone. Caution may be warranted with other agents that affect P-glycoprotein or that belong to the same class. Ensure the clinic knows all current preventives, recent dewormers, and any neurologic history. Do not combine with other heartworm preventives unless instructed by a veterinarian.

Use in ill, underweight, or hypersensitive dogs requires clinical judgment. If a dog tested positive for heartworm, stabilization and alternative protocols may be needed rather than extended-release prevention. The clinic will follow label guidance for testing and follow-up care.

What to Expect Over Time

After the injection, protection begins as the microspheres release medicine over months. Most dogs have no activity restrictions. The veterinary team may schedule a reminder for the next dose and recommend annual testing. Families often pair this prevention with separate flea and tick control to cover external parasites, since they are not addressed by this therapy.

Expect a brief clinic observation period after administration. Mild injection-site reactions can occur and typically resolve. If any unusual signs appear later, contact the veterinarian promptly. Consistent six-month scheduling supports continuous coverage through changing seasons.

Compare With Alternatives

Alternatives include monthly oral preventives that combine a macrocyclic lactone with other agents, topical combination medicines that add flea and tick coverage, and a separate 12-month injectable option where available. Monthly options can suit dogs that visit the clinic less often or those needing integrated external parasite control in a single dose form.

Which approach fits best depends on health status, lifestyle, and regional parasite risks. A veterinarian can compare long-acting injection against monthly tablets or topicals and help select an option that maintains consistent protection throughout the year.

Pricing and Access

Border Free Health lists current options with Canadian pricing and Canada sourcing, with Ships from Canada to US fulfilment to your address when permitted. Check the page for ProHeart 6 price details and availability. For additional offers, see our Promotions page. Final costs depend on strength, pack configuration, and prescription validation.

If the veterinarian prefers a different parasite plan, monthly preventives may be suggested. Explore broader options in Pet Medications. For related parasite topics, see Drontal For Dogs and Capstar Flea Treatment articles.

Availability and Substitutions

Stock can vary by market and clinic demand. If a particular pack size is unavailable, a prescriber may recommend a suitable alternative preventive or a different schedule. The clinic will consider testing, prior reactions, and parasite risks before substituting. For canine cardiac support topics, you can also review Cardalis For Dogs.

Patient Suitability and Cost-Saving Tips

Good candidates are healthy, heartworm-negative dogs that benefit from a long-acting schedule. Dogs with a history of allergic reactions, neurologic issues, or recent severe illness need careful evaluation. Puppies should meet the labeled minimum age. Annual or semiannual exam schedules align well with the six-month dosing window for convenience.

• Multi-month planning: coordinate biannual clinic visits with vaccination checks
• Set reminders: add calendar prompts for test and dose dates
• Bundle care: discuss combining wellness exams with preventive dosing
• Compare options: consider oral monthly choices if scheduling is difficult
• Documentation: keep prior records handy for faster clinic review

For antibiotic needs tied to other conditions, see Clavamox. Endocrine support options like Thyro Tab are also available for canine thyroid conditions. Educational content includes Doxycycline For Dogs and a general guide on where to Buy Pet Medications Online.

Questions to Ask Your Clinician

• Is my dog an appropriate candidate for the long-acting injectable preventive?
• What pre-injection testing and exam are required under the label?
• How should potential side effects be monitored after the clinic visit?
• Which flea and tick products pair well with a six-month heartworm preventive?
• What is the plan if a scheduled dose is delayed or missed?
• How does the injection compare with monthly oral or topical preventives?

Authoritative Sources

Zoetis: ProHeart 6

Zoetis: Prescribing Information

Heartworm Disease

Ready to proceed? Place an order with prompt, express shipping and we’ll coordinate prescription validation; temperature-controlled handling when required. This information is not a substitute for veterinary advice; always follow the official label and your veterinarian’s guidance.