Scemblix

Scemblix is a targeted therapy used to treat adults with chronic myeloid leukemia (CML) in chronic phase who have the Philadelphia chromosome and have been treated with at least two prior tyrosine kinase inhibitors (TKIs). It works differently from other CML treatments by specifically blocking the ABL myristoyl pocket, helping to slow or stop cancer cell growth.

Benefits

• Offers a new treatment option for patients who are resistant or intolerant to other CML therapies.
• Selectively targets the ABL myristoyl pocket, with fewer off-target effects.
• Can be effective where other tyrosine kinase inhibitors (TKIs) have failed.
• Oral medication that can be taken at home.
• May be associated with improved tolerability compared to previous CML therapies.

Dosage

• The standard dose is 40 mg twice daily.
• In cases involving a specific T315I mutation, the dose may be 200 mg twice daily.
• Should be taken at the same time each day, with or without food.
• Tablets should be swallowed whole with water.

Warnings and Precautions

• May increase liver enzyme levels — regular liver function tests are advised.
• Can cause high blood pressure or changes in pancreatic enzyme levels.
• Monitor blood counts regularly due to the risk of low white blood cells or platelets.
• Not recommended during pregnancy or breastfeeding.
• Inform your doctor about all current medications, as Scemblix can interact with other drugs.

Usage Instructions

• Take as prescribed, twice daily at the same time each day.
• Swallow tablets whole without crushing or chewing.
• Do not take a missed dose within 6 hours of the next scheduled dose.
• Keep appointments for routine blood work and monitoring.
• Do not stop the medication without your doctor’s guidance.

Storage Information

• Store at room temperature (20°C to 25°C).
• Keep tablets in the original packaging.
• Protect from moisture and direct sunlight.
• Keep out of reach of children.

Common Side Effects

• Mild to moderate effects: tiredness, headache, nausea, rash, joint pain, or abdominal discomfort.
• Serious (seek medical attention): signs of liver trouble (yellow skin or eyes, dark urine), severe bleeding, shortness of breath, chest pain, or unusual bruising.