Skyrizi® Pre-fill Cartridge w/ Injector for Crohn's Disease

Risankizumab-rzaa is a prescription biologic used for moderate to severe Crohn’s disease and other approved inflammatory conditions. This guide explains the prefilled cartridge and on-body injector, how it works, and how to plan access with US delivery from Canada without insurance.

What Skyrizi Is and How It Works

Skyrizi® is an interleukin-23 (IL-23) inhibitor. It targets the p19 subunit of IL-23 to help reduce inflammation associated with Crohn’s disease. The prefilled cartridge is used with an on-body injector to deliver maintenance doses under the skin after intravenous induction dosing. The class is designed to modulate the immune response rather than provide immediate symptom relief.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

This medicine is indicated in adults with moderate to severe Crohn’s disease who meet labeling criteria. It may also be approved for plaque psoriasis and psoriatic arthritis. For condition-specific guidance and resources, see our pages on Crohn’s Disease and Psoriatic Arthritis. Some patients with skin disease may use alternatives like Otezla when oral therapy is appropriate.

Who It’s For

This treatment is for adults diagnosed with moderate to severe Crohn’s disease who have completed the labeled intravenous induction schedule and are moving to subcutaneous maintenance. It may be considered when other therapies were not tolerated or did not work well enough. People with active, serious infections should not start until the infection is controlled. Those with a history of tuberculosis should be evaluated and managed according to guidelines before use. Discuss your medical history, including chronic infections and vaccination status, with a healthcare professional.

Dosage and Usage

After completing the labeled intravenous induction regimen, the on-body injector delivers a maintenance dose at the timepoint specified in the official prescribing information, and then at regular intervals. The device is applied to clean, intact skin on the abdomen or thigh as directed by the Instructions for Use. A clinician should show you how to load the cartridge, attach the injector, confirm readiness indicators, and start the delivery.

General steps typically include allowing the carton to reach room temperature out of the refrigerator as directed, inspecting the cartridge for clarity and the device for damage, preparing a site, and activating the injector. Do not shake the cartridge. Do not press on the device during delivery. The injector signals when the dose is complete; allow the device to finish before removal. Refer to the official label and Instructions for Use for all steps and timing, and contact your prescriber if you have questions about training or schedule.

Strengths and Forms

The maintenance presentation for Crohn’s disease includes a prefilled 360 mg/2.4 mL cartridge used with an on-body injector. Other presentations for psoriasis or psoriatic arthritis may include a prefilled pen or prefilled syringe. Availability can vary by market and over time.

Missed Dose and Timing

If a maintenance dose is missed, consult the official label for what to do next, or check with your prescriber for guidance. In general, take the dose as soon as possible if there is a significant gap, then return to your regular schedule. Do not double up doses to catch up. Try to take future doses on the same day of the week at the recommended interval to support consistent control.

Storage and Travel Basics

Store the cartridge in the refrigerator in its original carton to protect it from light. Do not freeze and do not shake. If needed for travel, keep the carton in an insulated container with cool packs so it does not get warm; do not place the medicine in direct contact with ice. Avoid extreme heat, and keep out of reach of children and pets. When traveling, carry the injector and supplies in your hand luggage along with a copy of your prescription. If airport security requires documentation, your prescriber can provide a letter listing the device and medical need. For household storage, choose a dedicated area away from food preparation and away from direct sunlight.

Pen Handling and Sharps Disposal

The on-body injector contains a hidden needle and an adhesive patch. Use a clean, dry site without scars, tattoos, or irritation. Rotate sites with each dose. After delivery, remove the device per the Instructions for Use and place it in an FDA-cleared sharps container. Do not throw used devices or cartridges in household trash. When the sharps container is about three-quarters full, follow your local community guidelines for disposal. If you need a container, many pharmacies and clinics can provide one or advise on low-cost options.

Benefits

This therapy is dosed at extended intervals for maintenance, which can reduce the number of injection days across the year. The on-body injector automates delivery and provides visual or audible indicators for dose progress. By targeting IL-23, the treatment focuses on a pathway implicated in intestinal inflammation. This may help reduce flare frequency and improve quality-of-life measures over time, according to labeling and clinical program summaries. The less frequent maintenance schedule can make planning travel and work activities easier compared to more frequent injections.

Side Effects and Safety

• Upper respiratory symptoms, such as sore throat or runny nose
• Headache or fatigue
• Injection-site redness or pain
• Fungal skin infections

Serious infections can occur. Seek medical help right away for fevers, persistent cough, shortness of breath, painful skin lesions, or other signs of systemic infection. Allergic reactions, including rash, hives, and swelling, can happen. Your clinician may test for tuberculosis before starting. Avoid live vaccines during therapy. If you are pregnant, planning pregnancy, or breastfeeding, discuss potential risks and benefits with your prescriber.

Drug Interactions and Cautions

Tell your healthcare professional about all medicines, vitamins, and herbal products you take. Use caution when combining with other strong immunosuppressants. Do not receive live vaccines during treatment. Inactivated vaccines may be given but talk with your prescriber about timing. Report any history of chronic or recurrent infection, latent TB, or hepatitis. Notify your care team if you develop new or worsening abdominal pain, significant weight loss, or persistent fever.

What to Expect Over Time

After IV induction, maintenance dosing with the on-body injector is designed to support sustained control. Some people notice gradual improvement in gastrointestinal symptoms as maintenance continues, while others may need additional time or adjustments per clinical judgment. Keep scheduled check-ins so your clinician can assess symptoms, labs, and safety. Plan ahead for refills and travel days so doses are not delayed. If budgeting is a concern, remember that Skyrizi prefilled cartridge with injector cost can vary based on quantity dispensed, market dynamics, and pharmacy service fees.

Compare With Alternatives

Other approved maintenance options for Crohn’s include different pathways or device formats. Your prescriber may discuss:

• Stelara — an IL‑12/23 inhibitor with subcutaneous maintenance dosing
• Omvoh Injection — an IL‑23 pathway option for certain inflammatory bowel diseases

Choice depends on diagnosis, prior therapies, coexisting conditions, and monitoring preferences. For background on immune-mediated conditions, see Autoimmune Diseases.

Pricing and Access

View current Canadian pricing and U.S. access by checking the product page and adding your prescription details. We verify prescriptions before dispensing and can coordinate transfers from your clinic. Temperature-controlled handling when required and careful packaging help protect quality in transit. For some patients, Risankizumab-rzaa 360 mg/2.4 mL cost may be influenced by insurance exclusions, quantity dispensed, and dispensing fees. If you are comparing suppliers, you can also review the Immunology category for context.

If you are looking at device affordability, you can compare the Skyrizi injection device price across fill intervals shown on the product page. For updates on seasonal offers, visit our Promotions. Canadian cash-pay options often provide value and Ships from Canada to US depending on your state’s import allowances.

Availability and Substitutions

Supply can vary by lot and by market. If the device is temporarily unavailable, your prescriber may recommend an alternative maintenance option or adjust the timing within label allowances. For approved patients, we make it simple to Order Skyrizi online once your prescription is verified. If a switch is needed, your care team will provide specific clinical guidance.

Patient Suitability and Cost-Saving Tips

Good candidates often include adults with confirmed moderate to severe Crohn’s disease who prefer less frequent maintenance dosing and can manage at-home device steps. People with uncontrolled infections, recent live vaccination, or prior severe hypersensitivity to components should avoid use. Build reminders into your calendar for site rotation and refills. Multi-month supplies, when appropriate, can reduce per-shipment fees and help you avoid gaps. For budgeting, consider manufacturer support, clinic samples, or third-party assistance if eligible. Some patients compare the Skyrizi cash price to clinic-administered options to decide on near-term affordability.

Questions to Ask Your Clinician

• Is IL‑23 inhibition appropriate for my disease history and goals?
• What tests do I need before and during maintenance treatment?
• How should I handle a missed maintenance dose or a delayed shipment?
• Which vaccines should I get before starting therapy?
• What symptoms should prompt me to contact you between visits?
• Can I travel with the device, and what documents should I carry?

Authoritative Sources

Ready when your prescription is? Buy Skyrizi prefilled cartridge with prompt, express shipping and secure US shipping from Canada. This content is for general information only and does not replace the advice of your healthcare professional.