Synjardy® Tablets for Type 2 Diabetes

Synjardy® is a prescription combination for type 2 diabetes. It pairs empagliflozin with metformin to lower blood sugar. This page explains how it works, who it suits, and how to access US delivery from Canada without insurance.

What Synjardy Is and How It Works

This medicine combines two well-studied diabetes agents. Empagliflozin is an SGLT2 inhibitor that helps your kidneys remove excess glucose through urine. Metformin decreases liver glucose production and improves insulin sensitivity. Working together, these actions help reduce fasting and post‑meal blood sugars when used with diet and activity.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

As Type 2 Diabetes care evolves, many adults benefit from simplified regimens. Empagliflozin/Metformin tablets offer two therapies in one, potentially reducing pill burden. The combination may also support modest weight changes and lower blood pressure in some people, consistent with SGLT2 class effects. Always follow your prescriber’s guidance and the official label.

Who It’s For

This treatment is indicated to improve glycemic control in adults with type 2 diabetes, as an adjunct to diet and exercise. It is not approved for type 1 diabetes or for treating diabetic ketoacidosis. People with significant kidney problems, severe dehydration, or a history of lactic acidosis should discuss risks with a clinician first. Those prone to genital yeast infections or urinary tract infections may need additional monitoring.

When discussing Synjardy uses with your prescriber, share your medical history and current medicines. That includes over‑the‑counter products and supplements. Review kidney function, alcohol intake, and any recent contrast imaging plans, as these factors can affect suitability.

Dosage and Usage

This combination is typically taken with meals. The immediate‑release version is usually dosed twice daily, while the extended‑release option is taken once daily with the evening meal. Your clinician will select a schedule based on prior therapy and tolerability.

Aim to take doses at the same time each day. Swallow tablets whole with water. Do not crush or chew extended‑release tablets. If stomach upset occurs, taking with food can help. Maintain hydration, especially during hot weather or when exercising.

Ask your clinician about Synjardy dosage if you are switching from separate components or adding to insulin or a sulfonylurea. Glucose self‑monitoring and periodic A1C checks help assess response and guide adjustments under medical supervision.

Strengths and Forms

This combination is available as immediate‑release tablets and as extended‑release tablets. Availability can vary by pharmacy and manufacturer supply.

• Immediate‑release: 5/500 mg, 5/1000 mg, 12.5/500 mg, 12.5/1000 mg
• Extended‑release: 12.5/1000 mg, 25/1000 mg

Discuss the extended‑release format if once‑daily dosing fits your routine. Synjardy XR may simplify administration for some adults. Your prescriber will match the format to your goals and tolerability.

Missed Dose and Timing

If you miss a dose, take it when remembered unless it is close to the next scheduled time. If it is nearly time for the next dose, skip the missed dose and resume the regular schedule. Do not double up to make up for a missed tablet. For once‑daily extended‑release, take the next dose at the usual time the following day.

Consistency matters. Set phone reminders, use a pill organizer, or coordinate doses with routine meals to support steady use.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed and out of reach of children and pets. Avoid storing in bathrooms where humidity is high. Keep in the original labeled container for easy identification.

For travel, pack your medicine in carry‑on luggage. Bring your prescription label and a current medication list. Carry glucose testing supplies and fast‑acting carbohydrates if you use therapies that can lower blood sugar. Protect the bottle from extreme heat or cold during transit.

Benefits

This therapy combines two complementary mechanisms in one tablet. Fewer separate medicines may simplify daily routines. Taking it with meals can fit naturally into your day. Many adults appreciate the option of once‑daily extended‑release.

Class effects of SGLT2 inhibitors can include reduced glucose levels independent of insulin, which may aid consistent fasting numbers. Metformin’s long track record provides additional support for lowering hepatic glucose output. Together, the combination can help you stay on your prescribed treatment plan.

Side Effects and Safety

• Digestive effects: nausea, diarrhea, stomach upset
• Genital yeast infections
• Urinary tract infections
• Increased urination or thirst
• Headache or mild dizziness

Serious risks are uncommon but can include lactic acidosis with metformin, diabetic ketoacidosis with SGLT2 inhibitors even if sugars are not very high, dehydration, acute kidney injury, and rare necrotizing infections of the perineum. Hypoglycemia can occur when used with insulin or a sulfonylurea. Seek medical attention for severe abdominal pain, rapid breathing, confusion, or signs of infection. Review the full safety profile in the official labeling.

Drug Interactions and Cautions

Tell your prescriber about diuretics, insulin, sulfonylureas, and other glucose‑lowering drugs. Diuretics may increase the risk of dehydration. Using insulin or a sulfonylurea can raise the chance of hypoglycemia; monitoring may be needed. Limit alcohol intake, which can increase metformin‑related risks.

Discuss temporary interruption before iodinated contrast imaging. Review kidney function periodically, as metformin is contraindicated in severe renal impairment. If you develop a serious infection, vomiting, or cannot maintain fluid intake, contact a clinician for guidance.

Learn more about medication classes in Different Types Of Insulin and broader therapy options in the Diabetes Drugs List.

What to Expect Over Time

Glucose improvements generally track with consistent use, diet, and activity. Your clinician may check fasting readings and A1C on a regular schedule to evaluate progress. Gastrointestinal effects often lessen as your body adapts, especially when taken with meals.

Keep a simple log of doses, meals, and readings. Note any genital or urinary symptoms and report them. If your plan includes insulin or a sulfonylurea, carry a source of fast‑acting carbohydrate and review hypoglycemia signs with your care team. Over months, many people settle into a routine that supports steady control.

Compare With Alternatives

Other combination options are available. Invokamet combines canagliflozin with metformin and may be considered when another SGLT2 inhibitor is preferred. If a DPP‑4 inhibitor strategy is appropriate, your prescriber might suggest pairing metformin with sitagliptin; see our listing for Sitagliptin Malate for details. Each option has distinct risks, benefits, and dosing schedules. Review choices with your clinician and the official labels.

Pricing and Access

Many patients compare options by total costs and fill schedules. Ask our team about current Synjardy price and Canadian pharmacy availability. We support transparent quotes and Promotions when applicable.

To understand out‑of‑pocket impact, you can discuss Synjardy cost without insurance with our support team. We provide encrypted checkout for security. Orders are fulfilled by licensed partners and Ships from Canada to US after prescription verification.

For therapy background, see related articles like Janumet How It Helps and SGLT2‑metformin topic coverage in Dapagliflozin And Metformin.

Availability and Substitutions

Stock can vary by strength and format. If a particular tablet is not available, a prescriber may recommend a comparable alternative or an adjusted regimen using separate components. We cannot guarantee restock dates. For origin details on select items, visit Canada.

Patient Suitability and Cost-Saving Tips

Good candidates are adults with type 2 diabetes needing improved control who can tolerate metformin and an SGLT2 inhibitor. It is not for type 1 diabetes or for people with severe kidney disease or past lactic acidosis. Those with frequent genital infections or at risk of dehydration should review precautions closely.

To manage costs, consider multi‑month supplies when appropriate, which can reduce per‑fill fees and travel time. Setting refill reminders helps prevent gaps. If side effects occur, contact your clinician early so small adjustments can keep you on track. For background on metformin formats, you may also read Glumetza Extended Release and broader diabetes awareness in National Diabetes Month 2025.

Questions to Ask Your Clinician

• Starting plan: how does this medicine fit with my current therapy?
• Monitoring: how often should I check glucose and A1C?
• Safety: what symptoms mean I should call for help?
• Illness plans: what should I do during dehydration or infection?
• Imaging: should I pause metformin before contrast studies?
• Travel: how should I store tablets during trips?

Authoritative Sources

FDA DailyMed | FDA Prescribing Information | Health Canada DPD

Ready to proceed? You can request a quote today and choose prompt, express shipping with US shipping from Canada after prescription verification. This information is not a substitute for professional medical advice; always consult your healthcare professional.