Tagrisso® Tablets for Non-Small Cell Lung Cancer

Tagrisso® is a targeted tablet used for certain EGFR-mutated lung cancers. This page explains how it works, standard dosing, safety, and practical access steps. You can explore Osimertinib price without insurance and options with US shipping from Canada.

What Tagrisso Is and How It Works

Tagrisso is the brand name for osimertinib, a third-generation EGFR tyrosine kinase inhibitor. It selectively targets sensitizing EGFR mutations and the T790M resistance mutation. By blocking EGFR signaling, it can slow tumor growth and support cancer control in eligible adults.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The treatment is taken by mouth once daily. Clinical labeling supports use as initial therapy for EGFR-mutated non-small cell lung cancer and after progression on earlier EGFR inhibitors when T790M is confirmed. It also has activity in the central nervous system. Talk with your healthcare professional about whether Tagrisso 80mg is appropriate for your situation.

Who It’s For

This medicine is indicated for adults with metastatic EGFR mutation–positive non-small cell lung cancer, including common mutations like exon 19 deletions and L858R substitutions. It is also approved as adjuvant therapy after tumor resection in EGFR mutation–positive disease. A companion diagnostic is typically used to confirm mutation status before starting therapy.

People with a history of hypersensitivity to osimertinib or tablet excipients should avoid it. Caution is advised for those with risk factors for interstitial lung disease, heart failure, or prolonged QT interval. Use in pregnancy can harm a developing fetus, and effective contraception is recommended during treatment and for a period after the last dose; review the official label for details.

Learn more about the condition in our category pages for Non Small Cell Lung Cancer and Cancer.

Dosage and Usage

The standard recommended dose is 80 mg by mouth once daily, with or without food. Swallow tablets whole with water. If you cannot swallow whole tablets, disperse a tablet in 60 mL of noncarbonated water, stir until pieces are evenly dispersed (the tablet will not fully dissolve), and drink immediately. Rinse the glass with an additional half glass of water and drink to ensure the full dose is taken.

Avoid taking this medicine with strong CYP3A inducers such as rifampin or St. John’s wort. Discuss all medicines and supplements with your prescriber. Do not change your dose unless your healthcare professional instructs you to do so. Patients prescribed Osimertinib 80mg tablets should follow the exact instructions on the medication label.

Strengths and Forms

This treatment is supplied as film-coated oral tablets. Commonly available strengths include:

• 80 mg tablet, usually the standard daily dose
• 40 mg tablet, often used for dose adjustments

Your prescriber chooses the strength based on the treatment plan and any tolerability considerations. Availability may vary by pharmacy and lot, and some colors or markings can differ by manufacturer batch. If you have questions about Tagrisso 40mg availability, contact our team before you place your order.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember unless the next dose is due within 12 hours. If fewer than 12 hours remain, skip the missed dose and resume your usual schedule. Do not take two doses at the same time to make up for a missed dose. If repeated doses are missed, consult your prescriber for guidance.

Storage and Travel Basics

Store tablets at room temperature in the original container with the lid tightly closed. Keep the bottle dry and away from excess heat and direct light. Do not store in a bathroom. Keep out of reach of children and pets. If you transfer tablets to a weekly organizer, keep the original bottle and label available for reference.

When traveling, carry the medication in your hand luggage, along with your prescription and a copy of your medication list. Consider using a travel letter if you will cross borders. If time zone changes occur, maintain roughly 24 hours between doses. Our pharmacies use encrypted checkout and temperature-controlled handling when required.

Benefits

This therapy targets a known driver of certain lung cancers. It can be taken once daily, with or without food, which supports routine use. The medicine has documented central nervous system activity, an important consideration when brain metastases are present. As adjuvant therapy, it is used after surgery in EGFR mutation–positive disease based on labeled indications. Many people appreciate the flexibility of oral dosing and the ability to continue daily activities during treatment, when appropriate.

Side Effects and Safety

• Diarrhea
• Rash or dry skin
• Nail changes
• Mouth sores
• Cough or fatigue
• Decreased appetite

Serious risks can include interstitial lung disease/pneumonitis, heart problems such as decreased left ventricular ejection fraction, QT interval prolongation, eye disorders including keratitis, and rare severe skin reactions. Embryo-fetal toxicity is a concern; effective birth control is advised during treatment and for a period after the last dose. Your clinician may monitor heart function, electrolytes, and eye symptoms. Seek urgent care if you develop sudden shortness of breath, worsening cough, chest pain, severe eye pain, or fainting.

Drug Interactions and Cautions

Strong CYP3A inducers can lower drug levels and reduce effectiveness. Avoid agents such as rifampin, carbamazepine, phenytoin, and St. John’s wort. Combining with other medicines that prolong the QT interval may raise the risk of arrhythmias; your prescriber may review an ECG before and during therapy, especially if you take antiarrhythmics or have electrolyte imbalances. Tell your clinician about all prescription medicines, OTC products, and herbal supplements. Do not start or stop any therapy without medical advice.

What to Expect Over Time

Before starting, testing confirms the presence of an appropriate EGFR mutation. Your care team will outline a monitoring plan that may include periodic imaging, ECGs, and laboratory review. Some side effects may appear within weeks, while others can occur later. Report symptoms promptly so your prescriber can assess supportive care or dose adjustments if needed. Consistent daily dosing helps maintain steady levels; setting reminders can support adherence.

For background reading on lung health and awareness, you may find these resources helpful: World Lung Day, World Lung Cancer Day, Cancer Prevention Tips, and Respiratory Care Week.

Compare With Alternatives

Other approved targeted options may be considered based on tumor genetics and prior therapies. For EGFR mutation–positive disease, earlier-generation inhibitors such as Iressa are sometimes used in specific contexts. For RET fusion–positive lung cancer, a different targeted option like Retevmo may be appropriate. Molecular testing guides selection; your oncology team will tailor therapy to your results and treatment history.

Pricing and Access

We make it straightforward to check availability and Canadian pricing, with US delivery from Canada for eligible orders. Your final out-of-pocket amount depends on your prescription, quantity, and any add-on services requested. If you compare Osimertinib tablets price across options, review source, supply, and verification standards as part of your decision. For occasional savings, see our Promotions page for current offers.

Availability and Substitutions

Supply can vary. If the requested strength or pack size is unavailable, your prescriber may recommend an appropriate alternative or a different fill pattern. We do not substitute without prescriber approval. If you are seeking Osimertinib for sale and have questions about sourcing, contact our support team for guidance. For products originating in Canada, see our attribute page for Canada.

Patient Suitability and Cost-Saving Tips

Candidates generally have confirmed EGFR mutation–positive NSCLC and no contraindications to therapy. People with significant cardiac disease, uncontrolled electrolyte abnormalities, or prior severe lung toxicity may need careful evaluation. Share a full medication list with your clinician, including supplements. Those who are pregnant, or planning pregnancy, should discuss risks and timing.

To manage expenses, consider multi-month fills when appropriate, which can reduce per-dispense fees and help maintain continuity. Set refill reminders ahead of travel or imaging dates. If you are comparing Tagrisso cost per month, account for dose changes, supportive medicines, and lab monitoring. Our team can coordinate with your prescriber to align quantities with your care plan. Explore category resources on Cancer as you plan treatment and follow-up.

Questions to Ask Your Clinician

• Is my tumor confirmed EGFR mutation–positive, and which mutation is present?
• What baseline tests do I need before starting, such as ECG or eye exam?
• How will we monitor for heart, lung, and eye side effects during therapy?
• What symptoms should prompt an urgent call or visit?
• Could any of my medicines affect this therapy’s safety or exposure?
• How long might I stay on treatment if I am tolerating it?
• If I miss doses due to travel or illness, what steps should I take?

Authoritative Sources

• FDA Prescribing Information
• AstraZeneca Product Information
• Health Canada Drug Product Database

Ready to order from Borderfreehealth? Place your request with prompt, express shipping. Ships from Canada to US. This content is for general information and is not a substitute for medical advice. Always follow your prescriber’s guidance and the official label.