Please note: a valid prescription is required for all prescription medication.
Janumet XR is an extended-release tablet that combines sitagliptin and metformin hydrochloride for adults with type 2 diabetes. You can buy Janumet XR online and choose the tablet strength and quantity that match your clinician’s directions. The current Janumet XR price depends on the strength, tablet count, and product source shown during ordering.
Janumet XR is taken as part of a broader diabetes plan that usually includes diet, activity, glucose monitoring, and routine lab checks. Common strength references include 50/500 mg, 50/1000 mg, and 100/1000 mg tablets, with each number referring to one active ingredient in the combination. Use the strength on your treatment plan or medicine bottle when choosing between Janumet XR tablets.
Janumet XR Price and Strength Selection
The Janumet XR price is tied to the tablet strength and quantity you choose. A 50/1000 mg tablet is not interchangeable with a 100/1000 mg tablet unless your clinician changes the plan, because the sitagliptin amount differs. The total cost of Janumet XR can also change when the tablet count changes, even if the product name looks the same.
Strengths are written as sitagliptin/metformin hydrochloride extended-release amounts. For example, Janumet XR 50 1000 refers to 50 mg sitagliptin plus 1000 mg metformin XR in each tablet. Janumet XR 100 mg 1000 mg refers to 100 mg sitagliptin plus 1000 mg metformin XR in each tablet.
| Tablet wording | Practical meaning | What to match |
|---|---|---|
| Janumet XR 50/500 mg | 50 mg sitagliptin with 500 mg metformin XR | Your exact tablet strength and daily directions |
| Janumet XR 50/1000 mg | 50 mg sitagliptin with 1000 mg metformin XR | The sitagliptin amount and metformin XR amount |
| Janumet XR 100/1000 mg | 100 mg sitagliptin with 1000 mg metformin XR | Whether your clinician specified this strength |
Quick tip: Match both numbers on the tablet strength, not only the Janumet XR name.
How to Order Janumet XR Online
Choose the Janumet XR tablet strength and quantity shown during ordering, then follow the checkout prompts for your medication. If order information needs clarification, accurate clinician and medication details can help the pharmacy complete its review. BorderFreeHealth offers US delivery from Canada for appropriate orders through licensed pharmacy channels.
When reviewing the price of Janumet XR, compare the same strength, release type, and tablet quantity. A lower-looking total may simply reflect fewer tablets or a different strength. Janumet and Janumet XR are related products, but the XR form is extended-release and should not be substituted for immediate-release Janumet without clinical direction.
For broader browsing in the same condition area, the Type 2 Diabetes collection groups medicines and supportive items used in diabetes care. The Diabetes Care category can also help you view related products in one place.
What Janumet XR Is Used For
Janumet XR is used with diet and exercise to help improve blood sugar control in adults with type 2 diabetes mellitus. It is not for type 1 diabetes or diabetic ketoacidosis. The medication combines two ingredients that work in different ways to support glucose control.
Sitagliptin is a DPP-4 inhibitor. This medicine class helps incretin hormones work longer, which supports insulin release when blood sugar is elevated and can reduce glucagon levels after meals. Metformin is a biguanide that lowers glucose production in the liver and can improve how the body responds to insulin.
Janumet XR is not the same as metformin alone. Metformin is one ingredient in the combination, while Janumet XR also contains sitagliptin. Some people use separate sitagliptin and metformin tablets when dose flexibility is needed, while others use the combined XR tablet to reduce pill burden.
Tablet Form, Ingredients, and Release Type
Janumet XR is an extended-release tablet. The XR design changes how the metformin portion is released over time, which is why the tablet should generally be swallowed whole. Crushing, chewing, or splitting an extended-release tablet can interfere with how the medicine is released.
The two numbers in a Janumet XR strength are ingredient amounts, not a full dosing schedule for every person. Janumet XR 50 1000 mg uses and Janumet XR 100 mg 1000 mg uses are tied to the same approved treatment context: improving blood sugar control in adults with type 2 diabetes alongside diet and exercise. The right strength depends on your current regimen, kidney function, and tolerability.
Some people may notice a soft tablet shell in stool while taking an extended-release medicine. This can occur with certain tablet technologies and does not always mean the medicine failed to release. If you repeatedly see tablets that appear fully intact or your glucose readings change unexpectedly, contact a healthcare professional.
Timing, Meals, and Monitoring Basics
Product labeling commonly describes Janumet XR as taken once daily with a meal, often the evening meal, but individual directions can differ. Taking metformin-containing tablets with food may reduce stomach upset. Do not change the tablet count, strength, or timing without clinical guidance.
Kidney function matters because Janumet XR contains metformin. Your care team may check estimated glomerular filtration rate, often called eGFR, before starting and during therapy. Janumet XR is not recommended for people with severe kidney impairment, and temporary holds may be needed around certain imaging procedures or acute illness.
Long-term metformin therapy can lower vitamin B12 levels in some people. Testing may be considered if symptoms such as unusual fatigue, numbness, tingling, or anemia appear. Regular A1C, home glucose readings, kidney labs, and medication reviews help connect the tablet choice with real treatment goals.
Janumet XR is not promoted as a weight-loss medicine. Some people have little weight change, while others may see changes related to diet, activity, other diabetes medicines, or glucose control. Ask your clinician how weight, appetite, and blood sugar trends should be interpreted for your situation.
Storage, Travel, and Handling
Store Janumet XR tablets at room temperature in a dry place, away from excess heat and moisture. Keep the container tightly closed and out of reach of children. Do not use tablets after the expiration date printed on the container.
When traveling, keep the medication in its original labeled container. Carry it with you rather than placing it in checked luggage, especially if travel involves temperature changes or delays. A current medication list is useful if you also carry glucose-monitoring supplies, insulin, or other diabetes medicines.
Order handling may include prompt, express shipping when supported for the item being purchased, without a guaranteed delivery date. Products connected to Canadian sourcing can also be browsed by country of origin in Canada when that attribute is relevant to your order review.
Side Effects, Warnings, and Monitoring
Common Janumet XR side effects can include diarrhea, nausea, stomach upset, decreased appetite, headache, and upper respiratory symptoms. Stomach effects may improve when metformin-containing tablets are taken with food. Persistent, severe, or unusual symptoms should be discussed with a healthcare professional.
Metformin can rarely cause lactic acidosis, a serious buildup of acid in the blood. The risk is higher with significant kidney impairment, severe dehydration, heavy alcohol use, liver problems, low oxygen states, sepsis, or some acute illnesses. Seek urgent care for symptoms such as severe weakness, unusual muscle pain, trouble breathing, stomach pain with vomiting, dizziness, slow heartbeat, or feeling very cold.
Sitagliptin has been associated with pancreatitis. Severe or persistent abdominal pain, especially pain that spreads to the back or occurs with vomiting, needs urgent medical attention. Serious allergic reactions can also occur and may involve swelling, rash, hives, blistering skin, or trouble breathing.
Low blood sugar is less likely when Janumet XR is used without insulin or a sulfonylurea, but the risk can rise when those medicines are part of the same plan. Symptoms may include sweating, shakiness, fast heartbeat, confusion, hunger, or weakness. Your clinician may adjust other glucose-lowering medicines to reduce hypoglycemia risk.
- Kidney disease: ask how often eGFR should be checked.
- Heavy alcohol use: discuss lactic acidosis risk before use.
- Past pancreatitis: mention it before continuing therapy.
- Contrast imaging: ask whether metformin should be paused.
- Upcoming surgery or severe illness: ask for sick-day instructions.
Interactions and Situations to Review
Tell your healthcare professional about prescription medicines, non-prescription products, vitamins, supplements, and herbal products. This is especially important if you use insulin, sulfonylureas, diuretics, carbonic anhydrase inhibitors, medicines that affect kidney function, or drugs that can increase metformin exposure.
Iodinated contrast used in some imaging procedures can require planning with metformin-containing medicines. Dehydration, vomiting, diarrhea, reduced food intake, or acute infection can also change safety considerations. Having sick-day guidance before illness occurs can reduce confusion when blood sugar and hydration are harder to manage.
Janumet XR should not be used by people with metabolic acidosis, including diabetic ketoacidosis. It is also not appropriate for people with a serious hypersensitivity reaction to sitagliptin, metformin, or other product components. Individual suitability depends on medical history, kidney function, current medicines, and treatment goals.
Janumet and Janumet XR Compared
Janumet and Janumet XR contain sitagliptin and metformin, but they are not the same form. Janumet XR uses an extended-release metformin component, while immediate-release Janumet has a different release profile. The difference can affect timing, tablet handling, and how the regimen is written.
Do not switch between Janumet and Janumet XR based only on product name or cost. The tablet strength, release type, and directions need to align. If a medication plan mentions sitagliptin metformin XR, that wording points to the extended-release combination rather than metformin alone or sitagliptin alone.
Broader articles in the type 2 diabetes education section can help explain treatment concepts that often come up during medication reviews. Use education content to support better questions, not to replace individualized medical guidance.
Questions to Ask Before Checkout
Before finalizing an order, make sure the Janumet XR tablet strength matches both ingredient amounts in your current directions. Confirm the quantity, extended-release form, and active ingredients. If you are comparing Janumet XR 50 1000 price with Janumet XR 100 mg 1000 mg price, compare the same tablet count and release type.
Ask your clinician what glucose targets, A1C goals, kidney monitoring, and side effect thresholds apply to you. Also ask how to handle missed doses, vomiting or diarrhea, imaging procedures, surgery, and changes in other diabetes medicines. Practical questions at checkout can prevent medication mix-ups later.
- Strength: match both sitagliptin and metformin amounts.
- Form: make sure the tablet is Janumet XR.
- Quantity: compare the total tablet count.
- Monitoring: ask about eGFR and A1C timing.
- Safety: know urgent symptoms before they happen.
Authoritative Sources
DailyMed official Janumet XR labeling provides ingredient, indication, dosing, warning, contraindication, and storage information.
Merck prescribing information for Janumet XR provides manufacturer labeling and detailed safety information for sitagliptin and metformin hydrochloride extended-release tablets.
This content is for informational purposes only and is not a substitute for professional medical advice.
Blood Glucose Unit Converter
Convert glucose readings between mg/dL and mmol/L without changing the clinical value.
These calculations are for education only and do not replace clinical advice, diagnosis, or treatment. Always confirm medical decisions with a qualified healthcare professional.
HbA1c & eAG Calculator
Convert between HbA1c percentage and estimated average glucose using the ADAG relationship.
These calculations are for education only and do not replace clinical advice, diagnosis, or treatment. Always confirm medical decisions with a qualified healthcare professional.
eGFR Calculator
Estimate kidney filtration using the 2021 CKD-EPI creatinine equation.
These calculations are for education only and do not replace clinical advice, diagnosis, or treatment. Always confirm medical decisions with a qualified healthcare professional.
HOMA-IR Calculator
Estimate insulin resistance from fasting glucose and fasting insulin values collected from the same blood draw.
These calculations are for education only and do not replace clinical advice, diagnosis, or treatment. Always confirm medical decisions with a qualified healthcare professional.
CGM Time-in-Range Summary
Summarise CGM percentages across very low, low, in-range, high, and very high glucose bands.
These calculations are for education only and do not replace clinical advice, diagnosis, or treatment. Always confirm medical decisions with a qualified healthcare professional.
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What is Janumet XR used for?
Janumet XR is used with diet and exercise to help improve blood sugar control in adults with type 2 diabetes mellitus. It is not used for type 1 diabetes or diabetic ketoacidosis.
Is Janumet XR the same as metformin?
No. Janumet XR contains metformin hydrochloride extended-release plus sitagliptin. Metformin is one ingredient in the combination, while sitagliptin is a DPP-4 inhibitor that works through a different glucose-control pathway.
What is the best time of day to take Janumet XR?
Labeling commonly describes Janumet XR as taken once daily with a meal, often the evening meal, but your own directions may differ. Taking it with food can help reduce metformin-related stomach upset.
Does Janumet XR cause weight loss?
Janumet XR is not a weight-loss medicine. Weight may stay similar or change because of diet, activity, glucose control, or other diabetes medicines. Ask your clinician how to track weight changes in your plan.
What are common Janumet XR side effects?
Common side effects can include diarrhea, nausea, stomach upset, decreased appetite, headache, and upper respiratory symptoms. Seek urgent care for symptoms of lactic acidosis, pancreatitis, or a serious allergic reaction.
Can Janumet and Janumet XR be substituted for each other?
Not without clinical direction. Janumet XR is an extended-release tablet, while Janumet is an immediate-release combination. The release type, strength, and timing need to match the treatment plan.
How should Janumet XR tablets be stored?
Store Janumet XR at room temperature in a dry place, away from excess heat and moisture. Keep the container tightly closed, out of reach of children, and do not use tablets past the expiration date.
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