Juluca® Tablets for HIV-1 Maintenance

This two-drug HIV-1 maintenance tablet helps eligible adults stay on therapy. You can access Canadian pricing with US delivery from Canada through Border Free Health. Many pay less even without insurance when they compare cash options.

What Juluca Is and How It Works

Juluca® combines dolutegravir, an integrase strand transfer inhibitor, and rilpivirine, a non-nucleoside reverse transcriptase inhibitor. Together, these agents block key steps in the HIV life cycle to help maintain viral suppression in adults who are already undetectable. As a complete regimen, it reduces pill burden to a single daily tablet taken with a meal.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

As dolutegravir rilpivirine tablets, the treatment is designed for people with no history of treatment failure and no known or suspected resistance to either component. It does not treat hepatitis B. If you have HBV and are switching from a regimen active against HBV, your prescriber may add separate HBV therapy.

You should review the official prescribing information for detailed instructions. This page summarizes label-based points to help you prepare for a discussion with your clinician.

Who It’s For

This medicine is indicated for adults with HIV-1 who are virologically suppressed on a stable regimen and have no known resistance to dolutegravir or rilpivirine. It may suit people aiming to simplify therapy to one tablet per day.

It should not be used with proton pump inhibitors such as omeprazole. People with a history of treatment failure, documented resistance to either component, or significant drug interactions should avoid it. Use is not recommended in severe hepatic impairment. Breastfeeding is not recommended for those with HIV. If you are pregnant or planning pregnancy, discuss alternatives because exposures to these agents can change during pregnancy.

Dosage and Usage

The usual schedule is one tablet once daily with a meal at about the same time each day. Swallow whole with water. Taking it with food is required for rilpivirine absorption and helps support consistent levels.

If you use antacids, take this treatment at least 4 hours before or 6 hours after antacids containing aluminum, magnesium, or calcium. If you use iron or calcium supplements, you may take them together with this medicine only if the dose is taken with a meal; otherwise, separate by at least several hours. If you take an H2-receptor antagonist like famotidine, take this medicine at least 4 hours before or 12 hours after the H2-blocker.

Do not change your dose or timing without guidance from your prescriber. The combination Dolutegravir/Rilpivirine 50/25 mg is taken as a single tablet per day; no additional antiretrovirals are needed unless your clinician advises otherwise.

Strengths and Forms

The product is supplied as film-coated tablets for oral use. The most common presentation is Juluca 50 mg/25 mg tablets containing dolutegravir 50 mg and rilpivirine 25 mg. Packaging may vary by manufacturer lot and jurisdiction. Availability can change due to market conditions and supply from Canada.

Missed Dose and Timing

If you miss a dose and remember within about 12 hours of the usual time, take the tablet with a meal as soon as you remember. If more than 12 hours have passed or it is very close to your next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once. Consistent daily timing helps maintain suppression.

Storage and Travel Basics

Store at room temperature in the original bottle with the desiccant, and keep the cap tightly closed to protect from moisture. Keep out of reach of children and pets. When traveling, carry the labeled container in your hand luggage along with a copy of your prescription. If your trip crosses time zones, keep doses spaced roughly 24 hours apart and continue to take with a meal. Our partners use temperature-controlled handling when required during transit.

Benefits

This two-drug regimen may reduce pill count to one tablet daily, which can simplify routines. Taking it with food helps with predictable absorption. For eligible adults who are already undetectable, staying on therapy with a streamlined regimen may support adherence while maintaining viral suppression. Your healthcare professional can help determine if this approach fits your treatment history.

Side Effects and Safety

• Common effects: headache, nausea, diarrhea, dizziness, trouble sleeping, and fatigue.
• Other reported effects: abnormal dreams, anxiety, depressed mood, and rash.

Serious reactions can include severe skin reactions or hypersensitivity, liver problems, depressive disorders or suicidal thoughts, and heart rhythm changes with rilpivirine when combined with certain other medicines. Weight gain has been observed with some modern antiretroviral regimens. Contact a clinician promptly if you notice signs of severe rash, jaundice, dark urine, shortness of breath, fainting, or mood changes.

If you have chronic hepatitis B or C, your prescriber may monitor liver tests more closely. This medicine is not a treatment for HBV.

Drug Interactions and Cautions

Do not use with proton pump inhibitors such as omeprazole or esomeprazole. Avoid strong enzyme inducers including rifampin, rifapentine, carbamazepine, oxcarbazepine, phenobarbital, phenytoin, systemic dexamethasone (except a single dose), and St. John’s wort. These can lower rilpivirine or dolutegravir levels and risk loss of virologic control.

Dofetilide is contraindicated due to potential for serious effects. Use caution with other drugs that prolong the QT interval. Dolutegravir can increase metformin levels; your prescriber may adjust metformin if you use both. Separate doses from products containing polyvalent cations as noted above.

Tell your healthcare professional about all prescription and non-prescription medicines, vitamins, and minerals you take. Review the full prescribing information for a complete interactions list.

What to Expect Over Time

Most people switching to this regimen are already undetectable at baseline. Your clinician will monitor viral load and CD4 counts to ensure suppression continues. It may take several weeks of consistent daily dosing to fully adjust to a new routine. Keep taking the tablet with a meal, use reminders if needed, and attend scheduled lab visits. If lab results change or side effects feel hard to manage, your prescriber may reassess your regimen.

Compare With Alternatives

Other complete regimens may be suitable depending on treatment history and resistance testing. One option is Delstrigo®, which combines doravirine, lamivudine, and tenofovir disoproxil fumarate. Some patients may remain on boosted protease inhibitor–based therapy when clinically appropriate, such as legacy regimens that include Kaletra® Solution in specific scenarios. Your clinician can help compare choices. For background reading, see our article Biktarvy Guide.

Pricing and Access

We list transparent pricing so you can compare options and discuss coverage with your prescriber. Cash-pay shoppers often ask about the Juluca price relative to other complete regimens. You can view current pricing, see what documentation is needed, and place an order for US delivery from Canada.

Border Free Health supports secure checkout and prescription verification before dispensing. If you are looking for deals, check our periodic Promotions. For broader context on options, explore the Antivirals category and our condition hub for HIV.

Availability and Substitutions

Supply can vary based on manufacturer and import timing. If the specific brand or pack is temporarily unavailable, your prescriber may recommend an alternative complete regimen that matches your history and resistance profile. Some shoppers ask whether they can Buy Dolutegravir/Rilpivirine as a straightforward substitution; any change requires a clinician’s review to ensure it is appropriate for your case.

Country-of-origin details are listed on product pages when available. For sourcing details, see Canada.

Patient Suitability and Cost-Saving Tips

This regimen may fit adults who are undetectable, have no known resistance to either component, and do not take interacting medicines such as PPIs or strong enzyme inducers. It is not typically used to start therapy in people with high viral loads or unknown resistance profiles. Tell your prescriber about kidney or liver conditions, pregnancy plans, and all medicines and supplements you take.

• Multi-month fills: ask your prescriber if a 60- or 90-day supply is appropriate.
• Timing tools: set phone alerts to anchor dosing with a meal.
• Travel ready: keep a copy of your prescription in your carry-on.
• Refill reminders: reorder when two weeks of doses remain to avoid gaps.
• Education: learn testing basics in Types Of HIV Tests and symptom context in HIV AIDS Symptoms.

For more reading on older and adjunct therapies, see Aptivus Overview and Metformin And HIV. Community resources appear during awareness events such as HIV Testing Day.

Questions to Ask Your Clinician

• Am I a candidate based on my resistance history and current viral load?
• Do any of my medicines or supplements interact with this therapy?
• What lab schedule should I follow after switching regimens?
• How should I time antacids, iron, calcium, or H2-blockers with my dose?
• What signs or symptoms mean I should contact you promptly?
• If I become pregnant, which regimen would you recommend instead?

Authoritative Sources

• ViiV Healthcare
• FDA DailyMed
• Health Canada DPD

Ready to proceed? Order Juluca online and complete checkout for US delivery from Canada with prompt, express shipping. Prescription required. This information is educational and not a substitute for professional medical advice.