Imvexxy® vaginal inserts for Dyspareunia

Imvexxy is a low-dose local estrogen therapy used to treat moderate to severe vaginal pain with sex due to menopause. This page helps you understand how the inserts work, who they suit, and how to use them safely.

We also outline access, including US shipping from Canada, and how to compare options. If paying cash, you can review Imvexxy without insurance alongside related therapies.

What Imvexxy Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Imvexxy® contains estradiol in small, fingertip-inserted softgels designed for vaginal use. As Imvexxy Uses articles explain, local estrogen helps restore vaginal tissue thickness, elasticity, and moisture. This can reduce dryness and discomfort related to menopause. With minimal systemic absorption relative to systemic products, the treatment focuses its effect locally. Imvexxy vaginal inserts are one option within this class.

Estrogens act by binding estrogen receptors, promoting cell growth and lubrication in the vaginal epithelium. This medicine may also improve pH and support a healthier vaginal environment. Use the lowest effective dose for the shortest duration that controls symptoms, in line with label guidance.

Who It’s For

This therapy is indicated for postmenopausal individuals with moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy due to menopause. Low dose vaginal estrogen inserts can be considered when moisturizers and lubricants are not enough. A clinician should confirm that symptoms align with genitourinary syndrome of menopause.

People with certain conditions should avoid local estrogen unless a prescriber deems it appropriate. Contraindications include unexplained vaginal bleeding, known or suspected estrogen-dependent cancer, active or past blood clots, arterial thromboembolic disease, liver disease, or hypersensitivity to components. Discuss personal and family history of breast cancer, clotting disorders, stroke, or heart disease with a clinician before starting therapy.

For broader context on menopause care, see Menopause And Beyond or condition pages for Dyspareunia and Vaginal Atrophy.

Dosage and Usage

Follow the official label and your prescriber’s directions. Typical schedules include an initial phase with daily insertion for two weeks, then a maintenance phase two times each week. Insert one softgel deep into the vagina using a clean finger. Many prefer bedtime use to limit leakage; however, timing can be adjusted to personal routines.

Wash hands before and after handling. Do not swallow the insert. If another vaginal product is needed, space usage as directed by your clinician. The goal is symptom control with the lowest effective exposure. Imvexxy softgel inserts are for local use only; do not use for systemic menopausal symptoms unless instructed.

Strengths and Forms

The inserts are available as fingertip-sized softgels for vaginal insertion. Published strengths include Imvexxy 4 mcg and a higher option at 10 mcg. Availability may vary by pharmacy and manufacturer supply. Your prescriber will choose a starting dose and maintenance schedule consistent with symptom severity and treatment goals. Always follow the label and your clinician’s advice regarding dose adjustments.

Missed Dose and Timing

If a maintenance dose is missed, insert it when remembered unless it is almost time for the next scheduled dose. If it is near the next dose, skip the missed dose and return to the regular schedule. Do not insert two doses at once. Establish a routine and use reminders to support adherence over time.

Storage and Travel Basics

Store the product at room temperature in the original packaging. Protect from moisture and keep out of reach of children and pets. Do not use inserts that are damaged or past their expiration date. For trips, keep the carton with its label in your carry-on bag. When traveling, you can pack a copy of the prescription or a photo of the label to answer security questions. If crossing borders, carry documentation that matches your name and the medication label. Our checkout is encrypted for your security.

Benefits

This class may relieve vaginal dryness, burning, and pain with intimacy related to menopausal atrophy. Local therapy concentrates activity in vaginal tissues, which can be useful when nonhormonal products are not enough. The softgel design allows fingertip insertion without an applicator, which some find simple. Maintenance dosing two times a week after the initial period offers a convenient schedule for ongoing management.

Side Effects and Safety

• Vaginal discharge or irritation
• Spotting or bleeding
• Breast tenderness
• Headache
• Pelvic discomfort
• Urinary burning or urgency
• Yeast infection

Serious risks associated with estrogen therapy include endometrial cancer, stroke, blood clots, and breast cancer. Although systemic exposure is lower with local treatments, warnings still apply. Use the lowest effective dose for the shortest time that manages symptoms. People with a uterus should report any unexplained bleeding promptly. Seek urgent care for signs of clot, stroke, or chest pain.

Drug Interactions and Cautions

Systemic exposure is generally lower with local therapy, but interactions may still be relevant. Strong CYP3A4 modulators can alter estrogen levels. Tell your clinician about all prescriptions, over-the-counter products, and herbal supplements such as St. John’s wort. Use caution with conditions such as high triglycerides, thyroid disorders, fluid retention, gallbladder disease, or hereditary angioedema. Regular re-evaluation helps ensure benefits continue to outweigh risks.

What to Expect Over Time

With consistent use, comfort during intimacy may improve as tissues regain moisture and elasticity. Some individuals notice gradual changes as maintenance dosing continues. Keep follow-up visits so your clinician can reassess symptoms, examine the vaginal tissue if needed, and adjust therapy based on response. If symptom control is not adequate, your prescriber may discuss dose changes or alternatives according to the label and current guidelines.

Compare With Alternatives

Local estrogen therapies and selective estrogen receptor modulators are options for vaginal symptoms. A tablet insert such as Vagifem delivers estradiol directly to the vaginal tissue. A longer-acting ring like Estring Vaginal Ring 2mg offers sustained local estrogen release.

Non-estrogen options, such as ospemifene tablets, may be considered when estrogen is not appropriate. Your clinician can help compare local, oral, and ring-based choices based on medical history, convenience, and goals.

Pricing and Access

Canadian pharmacies often provide competitive pricing for self-pay customers, with US delivery from Canada available through our partners. To look at options, see womens health categories like Womens Health and country listings such as Country Of Origin Canada. If seeking discounts, our Promotions page lists current offers.

For self-pay, you can compare the Imvexxy cash price with similar therapies and select the option that fits your needs. Use the product page to review current pricing and submit a valid prescription during checkout.

Availability and Substitutions

Supply can vary by strength and manufacturer. If a requested strength is temporarily unavailable, a prescriber may recommend an alternative local estrogen or a different class, depending on your history and goals. Pharmacy teams dispense only against valid prescriptions and will not substitute without prescriber authorization unless permitted by law.

Patient Suitability and Cost-Saving Tips

Candidates include postmenopausal patients with bothersome dyspareunia due to vaginal atrophy who do not have contraindications to estrogen. Not all patients require the same approach; some may do well with nonhormonal products, while others need local estrogen. Multi-month fills can reduce per-fill costs and help maintain continuity. You can set refill reminders in your calendar to keep maintenance dosing on track. If paying cash, consider comparing local estrogen options side by side for both suitability and pricing. Explore category pages for context within your broader care plan.

Questions to Ask Your Clinician

• Is local estrogen appropriate for my symptoms and medical history?
• What initial schedule and maintenance plan should I follow?
• How will we monitor for side effects or rare risks?
• If I experience spotting, when should I seek evaluation?
• Are there nonhormonal options that might work for me?
• Could a ring or tablet insert suit my routine better?
• When should we reassess to confirm the lowest effective dose?

Authoritative Sources

FDA Prescribing Information

DailyMed: Imvexxy

Health Canada Drug Product Database

Ready to proceed? You can order with prompt, express shipping, and our team supports temperature-controlled handling when required. Ships from Canada to US. This information is not a substitute for medical advice; always follow your clinician’s guidance and the official label.