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Kivexa® Tablets for HIV
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Kivexa treats HIV-1 as part of a complete antiretroviral regimen. It combines two nucleoside reverse transcriptase inhibitors to help reduce viral load. If you are comparing options for Kivexa without insurance, this page explains what it is and how it’s used, with US delivery from Canada.
What Kivexa Is and How It Works
Kivexa® contains abacavir and lamivudine, a fixed-dose combination used with other antiretrovirals for adults and adolescents who meet weight criteria. This combination blocks reverse transcriptase, which HIV uses to replicate. Lower replication can reduce viral load when taken consistently with other medicines.
Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.
The treatment is not a cure, but it is a backbone component in many regimens. In the U.S., an equivalent abacavir/lamivudine product has been marketed as Epzicom. Your clinician will decide which agents to pair with this medicine based on guidelines and your history. See our Hiv and Antiretrovirals categories for context on related options.
Who It’s For
This combination is indicated for adults and for pediatric patients who weigh enough to use a fixed-dose tablet. It is used with other antiretrovirals to treat HIV-1 infection. People with moderate to severe liver impairment should not use this combination. Those with reduced kidney function may need different lamivudine dosing; the fixed-dose tablet may not be appropriate. Do not take it if you previously had an abacavir hypersensitivity reaction or if you carry HLA-B*5701 and your clinician advises against use.
Dosage and Usage
Standard labeling recommends one tablet once daily, taken with or without food, in combination with other antiretrovirals. Your prescriber may order an HLA-B*5701 test before starting to check the risk of abacavir hypersensitivity. Take the tablet at the same time each day to support adherence. Swallow whole with water. Do not restart abacavir-containing therapy if you ever had a hypersensitivity reaction to it. If you have kidney or liver issues, your prescriber will review whether a different regimen or dosing approach is needed. Always follow the official label and your clinician’s instructions.
Strengths and Forms
The combination is supplied as film‑coated tablets. A commonly published strength is Abacavir Lamivudine 600/300 mg per tablet. Availability may vary by manufacturer and country.
Missed Dose and Timing
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next dose at the regular time. Do not take two doses at once. If you stop because of symptoms that suggest a hypersensitivity reaction, do not restart; contact a healthcare professional promptly.
Storage and Travel Basics
Store tablets at room temperature in the original container, tightly closed. Keep away from excess moisture and heat, and out of reach of children and pets. When traveling, carry your medication in hand luggage with your prescription details. Keep a list of your medicines and doses. If crossing borders, allow extra time for screening of medicines and supporting documents. For broader context on international HIV care topics, see A Beginners Guide To Biktarvy and Aptivus For Hiv How It.
Benefits
This treatment simplifies two nucleosides into one daily tablet, which may support adherence compared to separate components. It can be paired with an integrase inhibitor or other third agent per guidelines. When taken consistently with the rest of your regimen, it helps reduce viral load and supports immune recovery. Tablet form allows use with or without food.
Side Effects and Safety
- Common: headache, nausea, diarrhea, fatigue, insomnia, nasal symptoms.
- Sometimes: rash, abdominal pain, vomiting, fever, cough, dizziness.
Serious risks include abacavir hypersensitivity reaction, which can be severe or fatal. Symptoms often include fever and rash, plus gastrointestinal and respiratory complaints. Stop therapy and seek care if a reaction is suspected. NRTIs can rarely cause lactic acidosis and severe hepatomegaly with steatosis. Worsening of hepatitis B can occur after stopping lamivudine in patients with HBV. Pancreatitis, anemia, neutropenia, and liver problems may occur. Immune reconstitution syndrome can appear after starting therapy. Cardiovascular risk factors should be considered when using abacavir.
Drug Interactions and Cautions
Avoid duplicate components with other abacavir or lamivudine‑containing products. Do not combine with emtricitabine if it would unnecessarily duplicate cytidine analogs. Alcohol can increase abacavir levels. Sorbitol-containing solutions can reduce lamivudine absorption. Methadone may require monitoring. Concomitant cladribine is generally not recommended. Tell your clinician about all medicines, vitamins, and herbal supplements. Hepatitis B status should be assessed before starting; stopping lamivudine can cause HBV flares. Screening for HLA-B*5701 is recommended before initiating abacavir.
What to Expect Over Time
With consistent dosing and an effective partner agent, viral load typically declines over weeks to months. Your clinician will monitor HIV RNA, CD4 count, liver enzymes, kidney function, and safety labs. Many patients continue long term if the regimen remains effective and well tolerated. Adherence is essential; setting reminders and aligning dosing with daily routines can help. If lab results or side effects suggest a change is needed, your prescriber may adjust your regimen.
Compare With Alternatives
Backbone options often include tenofovir-based pairs or abacavir/lamivudine, paired with a third agent such as an integrase inhibitor or NNRTI. A non-nucleoside option sometimes used as the third drug is Pifeltro (doravirine), taken with a nucleoside backbone. In the U.S., the abacavir/lamivudine combination has also been known as Epzicom. Your clinician will compare efficacy, comorbidities, and potential interactions to tailor the regimen.
Pricing and Access
We display transparent options to help you compare the Abacavir Lamivudine price, dispensing source, and availability. You can review Canadian pricing and arrange fulfilment that Ships from Canada to US, subject to a valid prescription. For periodic deals, see our Promotions page. Checkout is encrypted for your privacy and security.
Availability and Substitutions
Supply can vary by manufacturer and packaging. If an item is not available, a prescriber may recommend an alternative within the same class or a different backbone. Options depend on your medical history, lab results, and potential interactions. If you need Abacavir Lamivudine from Canada, our team can help you navigate options your clinician prescribes.
Patient Suitability and Cost-Saving Tips
This combination may suit adults and adolescents who meet weight thresholds, have adequate kidney function for fixed‑dose lamivudine, and do not have moderate to severe liver impairment. It is not suitable for anyone with prior abacavir hypersensitivity. Patients with cardiovascular risk factors should discuss benefits and risks with a healthcare professional.
- Multi‑month fills: ask your prescriber if a longer supply fits your plan.
- Refill reminders: set phone alerts to avoid missed doses and gaps.
- Travel buffer: carry extra tablets and a copy of your prescription.
- Review options: discuss generic abacavir/lamivudine and partner agents.
- Category search: browse Antivirals and Canada listings for context.
Questions to Ask Your Clinician
- Have I been screened for HLA‑B*5701 before starting abacavir?
- Is this backbone appropriate with my kidney and liver function?
- Which third agent pairs best with this combination for me?
- How will we monitor viral load, CD4, and organ function?
- What should I do if I develop rash, fever, or breathing symptoms?
- How does my cardiovascular risk affect agent choice?
- What is the plan if I have hepatitis B or C coinfection?
Authoritative Sources
FDA DailyMed | Health Canada DPD | Manufacturer Site
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What is Kivexa used for?
Kivexa is a fixed-dose combination of abacavir and lamivudine, used to treat HIV in combination with other antiretroviral drugs. It helps reduce the amount of HIV in the body and improve immune system function, allowing patients to live longer, healthier lives.
How should I take Kivexa?
Take Kivexa once daily with or without food. It’s important to take it at the same time each day to maintain consistent drug levels. Do not skip doses, as this can increase the risk of resistance.
Are there any serious side effects with Kivexa?
Yes, abacavir may cause a serious allergic reaction in some people. Your doctor will test you for the HLA-B*5701 gene before starting therapy. Symptoms like rash, fever, and fatigue require immediate medical attention.
Can Kivexa be taken during pregnancy?
Yes, but only under the supervision of a healthcare provider. The benefits must outweigh potential risks, and HIV-positive pregnant women are often treated to prevent transmission to the baby.
Does Kivexa cure HIV?
No, Kivexa is not a cure, but it helps manage HIV effectively. Continued treatment keeps the viral load low and reduces the risk of transmission. Consistent follow-up care and adherence are essential for long-term success.
Can I use this medicine if I test positive for HLA-B*5701?
If you have a positive HLA-B*5701 test, abacavir-containing regimens are generally avoided because of the risk for hypersensitivity reactions, which can be severe. Your clinician will typically select a different backbone. If you previously had symptoms of hypersensitivity while taking an abacavir product, do not restart it. Discuss your history, test results, and alternatives to find a safe regimen for your situation.
Is this combination safe during pregnancy or while breastfeeding?
Discuss pregnancy plans with your healthcare professional. Abacavir and lamivudine have been used in pregnancy, but the overall regimen should be individualized. People with HIV are usually advised not to breastfeed in settings where safe alternatives exist, to reduce postnatal transmission risk. Your clinician will consider viral load, partner drugs, and local guidance to determine the most appropriate plan.
What are signs of abacavir hypersensitivity I should watch for?
Watch for fever and rash accompanied by gastrointestinal symptoms like nausea, vomiting, or abdominal pain, and respiratory symptoms such as cough or shortness of breath. These may suggest hypersensitivity. If such a reaction is suspected, stop taking the abacavir-containing product and seek urgent medical evaluation. Do not restart the same medicine after a suspected reaction unless a clinician specifically instructs you.
Can I take it with methadone or alcohol?
Alcohol can increase abacavir exposure and is best limited. Methadone levels can change when used with certain antiretrovirals, so your clinician may monitor and adjust therapy as needed. Always provide a full list of medicines, including over-the-counter and herbal products, so your prescriber can check for interactions with abacavir/lamivudine and your third agent.
What if I have chronic hepatitis B as well as HIV?
Lamivudine has activity against hepatitis B virus. If you have HBV coinfection and later stop lamivudine, your liver disease may worsen. Your clinician may choose a regimen that also treats HBV and will monitor liver tests closely. Do not stop the tablets without medical advice, and make sure your prescriber knows your HBV status before starting therapy.
Do I need dose adjustments for kidney or liver problems?
Lamivudine requires adjustment in renal impairment, and the fixed-dose tablet may not be suitable if kidney function is reduced. Abacavir is not recommended in moderate to severe hepatic impairment, and dose changes may be needed for some patients with mild liver impairment. Your healthcare professional will determine whether a fixed-dose combination or separate components are appropriate.
Can I split or crush the tablet if I have trouble swallowing?
Swallowing tablets whole is generally preferred. Some clinicians may consider alternatives, such as separate components or different formulations, when swallowing is difficult. Because guidance can vary and stability data depend on the product, ask your prescriber or pharmacist before cutting or crushing any antiretroviral tablet. They can advise based on the official labeling and your treatment plan.
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