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Lynparza
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Lynparza (olaparib) is a PARP inhibitor used as targeted therapy for certain types of cancers, including ovarian, breast, pancreatic, and prostate cancers associated with BRCA mutations. It interferes with cancer cell DNA repair mechanisms, leading to cell death.
Benefits:
- Targeted therapy for BRCA-mutated cancers
- It can be used as a maintenance treatment for recurrent ovarian cancer
- Oral administration allows convenient at-home treatment
- May prolong progression-free survival in cancer patients
Dosage:
- Standard dose: 300 mg orally twice daily (adjustments may be needed)
- Take with or without food
- Swallow tablets whole
Warnings and Precautions:
- Risk of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML)
- Monitor for signs of bone marrow suppression
- It may cause fetal harm; avoid it during pregnancy
- Periodic blood tests required
Usage Instructions:
- Take doses approximately 12 hours apart
- Do not crush or chew tablets
- If a dose is missed, take it as soon as remembered unless close to the next dose
Storage Information:
- Store at room temperature (20–25°C)
- Could you keep it in the original container?
Common Side Effects:
- Fatigue
- Nausea
- Anemia
- Vomiting
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Shipping Countries:
- United States (all contiguous states**)
- Worldwide (excludes some countries***)
What is Lynparza used for?
Lynparza (olaparib) is an oral targeted therapy used to treat certain types of cancers, including ovarian, breast, pancreatic, and prostate cancers with specific BRCA gene mutations. It is often used as a maintenance therapy after initial treatment to delay cancer progression.
How does Lynparza work?
Lynparza inhibits the PARP enzyme, which is involved in DNA repair in cancer cells. By blocking this repair mechanism, Lynparza causes cancer cells—especially those with BRCA mutations—to die while sparing most healthy cells.
What are common side effects of Lynparza?
Common side effects include nausea, fatigue, anemia, and decreased appetite. Serious side effects can include bone marrow suppression and the risk of developing secondary cancers, so regular monitoring is essential.
How is Lynparza taken?
Lynparza is usually taken twice daily, with or without food. Capsules and tablets are not interchangeable, and it’s important to follow dosing instructions precisely.
Is genetic testing required before using Lynparza?
Yes, patients are typically screened for BRCA mutations or homologous recombination deficiency (HRD) to determine eligibility. Your oncologist will arrange for genetic testing if Lynparza is being considered.
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