Lynparza

Uses of Lynparza

Lynparza is a targeted cancer medicine used to treat specific types of ovarian cancer, breast cancer, fallopian tube cancer,  pancreatic cancer, prostate cancer, and peritoneal cancer. Lynparza is often used if your cancer has a specific genetic marker, including BRAC1, BRCA2, HRR, and HER2-negative. Your doctor will test you for this gene.

Precautions and Warnings

Lynparza affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, weakness, tiredness, trouble breathing, easy bruising or bleeding, blood in your urine or stools, or weight loss.

You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.

Some people who take olaparib with a gonadotropin-releasing hormone (GnRH) medicine may develop a blood clot in the leg or in the lung. Call your doctor if you have pain or swelling in your arm or leg, shortness of breath, chest pain, rapid breathing, or fast heartbeats.

Lynparza may also cause serious lung problems. Call your doctor if you have chest pain, wheezing, trouble breathing, or a new or worsening cough.

You should not use Lynparza if you are allergic to olaparib.

To make sure Lynparza is safe for you, tell your doctor if you have ever had:

• lung disease, breathing problems; or
• kidney disease.

Lynparza can harm an unborn baby or cause a miscarriage if the mother or the father is using this medicine.

If you are a woman, do not use this medicine if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose. Also do not donate sperm during the 3 months after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using this medicine

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

Dosage

The dose is usually 300 mg orally 2 times a day.  The dose may be changed by your doctor due to renal impairment or other factors.

Side Effects

Common side effects:

• Weakness
• Weight loss
• Fever
• Frequent infections
• Blood in urine or stool
• Shortness of breath
• Feeling very tired
• Bruising or bleeding more easily