Odefsey® Tablets for HIV-1 Treatment

This single-tablet HIV-1 regimen combines emtricitabine, rilpivirine, and tenofovir alafenamide. It is taken once daily with food. This page outlines use, dosing basics, safety, and ways you can manage access. You can review options without insurance and arrange US shipping from Canada.

What Odefsey Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

HIV treatment often uses complete regimens in a single pill. Odefsey® 200/25/25 mg tablets combine three agents to help maintain viral suppression in suitable patients. It includes emtricitabine (an NRTI), rilpivirine (an NNRTI), and tenofovir alafenamide (an NRTI prodrug).

The regimen works by blocking HIV reverse transcriptase and reducing viral replication. It is intended for people with no known resistance to its components. Taking it consistently with a meal supports rilpivirine absorption. Your prescriber will confirm it fits your history and current lab results.

This medicine is different from booster-based combinations. It does not include ritonavir or cobicistat. It may be used to replace a stable regimen in virologically suppressed adults when specific criteria are met.

Who It’s For

Odefsey used for the treatment of HIV-1 infection in adults and adolescents weighing at least 35 kg who have no known resistance to rilpivirine, emtricitabine, or tenofovir. It can also replace a stable regimen in patients who are virologically suppressed, have no history of treatment failure, and have no known resistance substitutions to its ingredients.

It is not for people with significant resistance to NNRTIs or the NRTIs it contains. Those with severe renal impairment or certain liver issues may need a different approach. Your healthcare professional will review your medications, medical conditions, and viral resistance testing before starting this treatment.

Dosage and Usage

The usual Odefsey dose is one tablet taken once daily with a meal. A meal is important for rilpivirine absorption; do not take on an empty stomach. Swallow the tablet whole.

If you take acid-reducing therapies, timing matters. Avoid proton pump inhibitors. Space H2-receptor antagonists and antacids according to label guidance described below. Keep a consistent schedule each day.

Do not change or stop therapy without speaking with your prescriber. If you also have hepatitis B, stopping this medicine can cause serious HBV flares; monitoring is required.

For detailed directions, review the official prescribing information or patient leaflet provided with the medication. If you have trouble swallowing tablets, ask your clinician about options; do not crush unless your prescriber confirms it is appropriate.

Strengths and Forms

The fixed-dose tablet contains emtricitabine/rilpivirine/tenofovir alafenamide 200/25/25 mg. It is typically supplied in a bottle of 30 tablets with a desiccant. Availability can vary by partner pharmacy.

This combination is designed as a complete regimen. Do not take it with other antiretrovirals unless your prescriber specifically instructs you to do so.

Missed Dose and Timing

If you miss a dose and it is within about 12 hours of your usual time, take it with a meal as soon as you remember. If more than 12 hours have passed, skip the missed dose and take the next dose at the regular time. Do not double up.

If you vomit within 4 hours after dosing, take another tablet with food. If vomiting occurs more than 4 hours after dosing, do not take an extra tablet; resume as scheduled the next day.

Storage and Travel Basics

Store tablets at room temperature in the original bottle with the desiccant to protect from moisture. Keep the container tightly closed and out of reach of children and pets.

When traveling, carry your medicine in your hand luggage with a copy of your prescription. Keep it in the labeled container to help with security checks. Avoid leaving tablets in hot cars or near sinks. If crossing borders, allow extra time for screening.

If you use pill organizers, keep the original bottle as your primary storage at home. Transfer only the doses you need, and replace the remainder promptly to reduce moisture exposure.

Benefits

This complete regimen offers once-daily dosing with food, which can simplify routines for many people. The combination may support bone and kidney marker improvements compared with some older tenofovir formulations, based on class data. It is intended to maintain suppression in people with appropriate resistance profiles.

Using a single tablet may help reduce missed doses. Consistent use, combined with regular follow-up, supports long-term viral control.

Side Effects and Safety

• Headache or dizziness
• Nausea or stomach discomfort
• Diarrhea
• Fatigue
• Insomnia or abnormal dreams
• Rash

Serious effects can include depressive symptoms or mood changes, severe rash, liver problems, kidney issues, or lactic acidosis related to nucleoside analogs. People with hepatitis B may experience serious exacerbations if therapy is stopped. Immune reconstitution syndrome can occur when starting effective therapy. Contact your prescriber promptly if you notice concerning changes in mood, jaundice, dark urine, shortness of breath, or other worrying symptoms.

Drug Interactions and Cautions

Odefsey and antacids require spacing. Take antacids at least 2 hours before or at least 4 hours after the dose. H2-receptor antagonists should be taken at least 12 hours before or at least 4 hours after the dose. Proton pump inhibitors are not recommended with rilpivirine-containing regimens.

Avoid strong CYP3A inducers such as rifampin, rifapentine, carbamazepine, oxcarbazepine, phenobarbital, phenytoin, and St. John’s wort. Use caution with drugs that prolong QT interval or significantly raise gastric pH. Tell your clinician about all medicines, vitamins, and herbal products you take.

For background on testing and treatment decisions, see our article Types Of HIV Tests. You can also explore related therapies in the Antivirals category.

What to Expect Over Time

With consistent dosing and follow-up, many patients maintain viral suppression on this regimen. Your clinician will monitor viral load and CD4 counts. If you are switching from a stable regimen, they will confirm eligibility and continue periodic lab checks.

Report mood changes, new medicines, or adherence challenges. Keeping a dose reminder on your phone and linking the dose to a daily meal can help. If your situation changes, your prescriber may reassess the plan.

For patient-friendly education on a similar single-tablet approach, you may find our guide helpful: Biktarvy Guide. For broader education, see HIV Symptoms and HIV Testing Day.

Compare With Alternatives

Other approved options include dolutegravir/lamivudine combinations (such as Dovato) for eligible adults, and integrase-based single-tablet regimens. For patients using an NNRTI backbone, doravirine-based therapy is an option in certain cases; see Pifeltro for details discussed with your prescriber. Your clinician will select based on resistance profile, comorbidities, and drug interaction risks.

Pricing and Access

We offer Canadian pricing with Canada Origin supply options and reliable US shipping from Canada. You can compare cash-pay options on the product page and see current availability. For condition education and self-advocacy before visits, explore our HIV category.

Savings CTA: Check if this therapy reduces your out-of-pocket costs compared with local cash prices. Pricing CTA: View today’s price and submit your prescription to start the verification process. Our encrypted checkout supports secure orders.

Availability and Substitutions

Stock can vary. If this combination is not available, your prescriber may recommend a therapeutically appropriate alternative that matches your resistance and health history. We cannot guarantee restock timing. Your pharmacist will coordinate with your clinician if a substitution is considered.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults and adolescents with no known resistance to its components, who can take a daily tablet with a meal, and who are not using interacting acid-reducing agents or potent enzyme inducers. It may not suit those with severe kidney issues, significant hepatic impairment, or a history of resistance to rilpivirine or the included NRTIs.

Cost-saving ideas:

• Multi-month fills: Ask your prescriber about 60- or 90-day supply to reduce per-fill fees.
• Refill reminders: Set phone alerts so you never miss a refill window.
• Lab timing: Coordinate lab work with refill cycles for efficient follow-up.
• Travel alignment: Plan refills before trips to avoid urgent purchases.

Questions to Ask Your Clinician

• Is my resistance profile appropriate for this regimen?
• Do any of my medicines affect gastric acid or rilpivirine levels?
• What should I watch for regarding mood changes or rash?
• How often will you check my viral load and kidney function?
• If I need antacids or H2 blockers, what timing is safest?
• What is the plan if I miss doses during travel or illness?

Authoritative Sources

Gilead Prescribing Information

FDA DailyMed

Health Canada DPD

Ready to proceed? You can place your order with prompt, express shipping. Always use as prescribed. Information here is educational and not a substitute for professional medical advice.