Sileo® Gel for Noise Aversion in Dogs

Sileo® Gel is a veterinary prescription gel used to calm dogs during loud events and sudden sounds. It helps reduce fear and agitation so your dog can settle more comfortably. We support US shipping from Canada and show clear options for pet caregivers, including viewing costs without insurance.

What Sileo Is and How It Works

Dexmedetomidine oromucosal gel for dogs helps reduce the intensity of noise-triggered anxiety. The active ingredient is an alpha-2 adrenergic agonist. It works by decreasing the release of norepinephrine in the central nervous system. This lowers arousal and helps many dogs cope with fireworks, thunderstorms, and similar stressors. You place the gel between the cheek and gums, where it is absorbed through the mouth lining.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The gel is intended for situational use tied to specific noise events. It is not a daily maintenance therapy. For broader behavior support, a clinician may also recommend desensitization plans or training tools. Learn about related topics in our Noise Aversion and Anxiety sections, or explore our wider range of Pet Medications.

Who It’s For

This treatment is for dogs with noise aversion. Common triggers include fireworks, thunder, gunfire, construction, and alarms. Signs may include trembling, panting, pacing, hiding, drooling, or attempts to escape. Dogs with moderate to severe reactions may benefit from having the gel ready ahead of expected events.

Dogs with serious heart disease, certain breathing problems, liver disease, or a history of fainting may not be good candidates. It may not be appropriate for pregnant, breeding, or lactating dogs unless a veterinarian decides the benefits outweigh the risks. Puppies and very small dogs require careful veterinary guidance.

Dosage and Usage

Sileo Gel dosage for dogs is weight-based and adjusted using the syringe’s dosing ring. Your veterinarian will provide a plan tailored to your dog’s body weight and response. When noise starts or is expected soon, turn the ring to your dog’s dose, put the tip between the cheek and gum, and press the plunger to deliver the gel onto the oral mucosa. Avoid feeding immediately around dosing so the gel can absorb as intended.

During a prolonged event, a prescriber may direct you to repeat dosing after a set interval. Many guidelines allow repeats separated by a minimum of about two hours, up to a limited number of doses per noise event. Always follow your veterinarian’s instructions and the official label for the exact schedule. If your dog swallows some gel, efficacy may be reduced; continue following the label and your prescriber’s guidance.

Strengths and Forms

Availability may vary by supplier and season. A common presentation is Sileo 0.1 mg/mL oromucosal gel for dogs in a multi-dose, 3 mL prefilled oral syringe with a locking ring. The device lets you set small, precise doses for different weights and repeat dosing when advised by a veterinarian.

Missed Dose and Timing

If a dose was planned but you missed it and the noise has started, give the dose as soon as feasible. If your dog is calmer than expected, do not give extra doses without veterinary direction. Space any follow-up doses as instructed by your prescriber and do not exceed the maximum number per event specified on the label.

Storage and Travel Basics

Store the syringe at typical room temperatures as directed on the official label. Keep it in the original carton to protect it from light. Do not freeze. Keep out of reach of children and pets. Once opened, many labels advise discarding the syringe after a limited in-use period; check the current product insert for the exact timeframe and follow those instructions.

For travel, pack the syringe in a secure container to prevent damage or accidental plunger movement. Carry your pet’s prescription information when flying or crossing borders. If your veterinarian anticipates summer storms or holiday fireworks, consider obtaining an adequate supply in advance. Our fulfilment uses temperature-controlled handling when required.

For country-of-origin details, see the Canada origin attribute across relevant listings.

Benefits

As a situational therapy, this medicine can help reduce the intensity of noise-triggered fear. Many caregivers appreciate the flexible dosing ring, the oral placement, and that the gel can be repeated during the same event when directed. Because it acts on central arousal pathways, the treatment may help dogs rest, settle, and cope better during loud events. It is used alongside behavior strategies, safe spaces, and sound masking for a combined approach.

Side Effects and Safety

Sileo Gel side effects can include sleepiness, lethargy, pale gums, vomiting, low body temperature, and unsteady movement. Some dogs may drool or seem disoriented. Rarely, paradoxical agitation may occur.

• Sleepiness or drowsiness
• Pale or bluish gums
• Vomiting or drooling
• Slowed heart rate
• Lowered body temperature
• Unsteady movement

Serious but uncommon risks include profound sedation, very slow heart rate, low blood pressure, and breathing difficulties. Dogs with cardiovascular or liver conditions require special caution. If your dog seems faint, collapses, or has trouble breathing, seek urgent veterinary care. Keep the syringe out of reach, as accidental human exposure can cause side effects like sedation or drops in blood pressure.

Drug Interactions and Cautions

Tell your veterinarian about all medicines, supplements, and preventives your dog uses. Combining this treatment with other sedatives, opioids, certain anesthetics, or blood pressure–lowering drugs may increase sedation or cardiovascular effects. Use caution with medicines that affect heart rhythm or circulation. Do not use other alpha-2 agonists at the same time unless your veterinarian specifically directs it. Follow your prescriber’s plan closely if your dog has chronic illnesses or is on multiple therapies.

What to Expect Over Time

For many dogs, dexmedetomidine gel for dogs can take effect around the time of the noise trigger when used as directed. You may notice calmer behavior, less pacing, and fewer escape attempts. Some dogs remain drowsy for a period after dosing. Practice the cheek-and-gum placement ahead of time with an empty syringe or a training treat to reduce handling stress. Maintain a quiet, safe space with familiar bedding, sound masking, and dim lighting.

Expect variability between dogs and events. Share observations with your veterinarian so they can adjust timing and the action plan. If your dog’s reactions escalate or new behaviors appear, follow up with your prescriber to review the care plan and rule out other conditions.

Compare With Alternatives

Veterinarians may consider other situational options based on your dog’s history, size, and concurrent conditions. Off-label choices such as trazodone or gabapentin can be considered in select cases. For background on one option, see our guide to Gabapentin For Dogs. Behavior modification and environmental strategies also help; browse our Noise Aversion resources for planning tips.

Pricing and Access

We list transparent options and offer Canadian sourcing with US delivery from Canada. You can compare current options and check availability before you add to your cart. Buy Sileo Gel online after your veterinarian sends a valid prescription, and track your order status in your account.

Looking for savings? Review current offers on our Promotions page. If you manage several pet needs at once, some caregivers find value in combining therapies within one order. You can also explore broader Pet Medications and related Anxiety topics to plan ahead.

Availability and Substitutions

Supply can vary due to manufacturing or demand. If the gel is temporarily unavailable, your veterinarian may recommend an alternative plan for your dog’s specific triggers. We do not quote restock dates, but you can check back or ask your prescriber about other options that suit your dog’s health status.

Patient Suitability and Cost-Saving Tips

Dogs with predictable seasonal triggers, like summer storms or holiday fireworks, may benefit from having multiple syringes on hand. Caregivers can schedule refill reminders before peak seasons. Multi-syringe orders may reduce the number of separate shipments for your household. Keep a written dosing plan with your pet’s collar or crate for quick reference during noisy events.

If your pet also takes chronic therapies, consider combining pet items in one checkout when timing allows. For example, dogs with adrenal insufficiency may need Zycortal, and parasite control may include options discussed in Drontal For Dogs resources. For broader canine care, see our Guide To Insulin.

Questions to Ask Your Clinician

• Is my dog a candidate for this medicine based on heart and liver health?
• What dose should I use for my dog’s current weight?
• How soon before noise should I give the first dose?
• What is the minimum time between repeat doses during one event?
• Which signs mean I should skip a repeat dose?
• Which other medicines should I avoid on the same day?
• How long can I keep an opened syringe before discarding it?

Authoritative Sources

Manufacturer: Zoetis

FDA Animal Drugs Database

Health Canada Drug Product Database

Ready to order? Add your prescription and check out with prompt, express shipping. Ships from Canada to US. This information is educational and not a substitute for your veterinarian’s advice. Always follow the official label and your prescriber’s directions.