Domperidone® Tablets for Nausea and Gastroparesis

What Domperidone Is and How It Works

Domperidone is a prescription medicine used for nausea and symptoms linked to slow stomach emptying. It acts on dopamine D2 receptors in the gut to improve gastric motility and reduce queasiness. We support US delivery from Canada so you can access Canadian options, and you can compare choices without insurance. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The first-line presentation is often a domperidone 10 mg tablet. This medicine works mainly in the gastrointestinal tract, limiting central nervous system effects due to minimal penetration into the brain. By enhancing coordinated contractions, it can help move food through the stomach and reduce feelings of fullness and bloating. See our overview on how it works in Mechanism And Benefits for more context.

Domperidone® is not FDA-approved for use in the United States. In Canada, it is authorized for nausea and vomiting and to address symptoms associated with delayed gastric emptying. Use the lowest effective dose for the shortest appropriate duration, following your prescriber’s guidance and the official label.

Who It’s For

This treatment is used to relieve nausea, vomiting, and upper GI motility symptoms. Some adults with diabetic or idiopathic delayed gastric emptying may benefit when a clinician deems it appropriate. When guided by a prescriber, domperidone for gastroparesis can be considered in select cases.

It is not appropriate for everyone. People with known prolonged QT interval, significant electrolyte disturbances, moderate or severe liver impairment, or known intestinal obstruction, perforation, or bleeding should avoid it. Those taking certain QT-prolonging medicines or strong CYP3A4 inhibitors should also avoid use. It is not approved to increase milk supply; any use related to lactation should be discussed carefully with a healthcare professional and aligned to local regulations.

Explore related conditions and context in our categories for Gastroparesis and Nausea And Vomiting.

Dosage and Usage

Follow your prescriber’s instructions and the official label. A typical adult schedule uses the lowest effective dose, taken 15 to 30 minutes before meals. A common approach uses small, divided doses across the day, tailored to symptoms and response.

Some adults are directed to start with domperidone 10mg taken before meals. Your prescriber may limit total daily intake and duration to lower cardiac risk. Swallow tablets with water and avoid crushing unless your prescriber or pharmacist confirms it is acceptable for your specific product.

If you take other medicines, separate administration as advised by your prescriber or pharmacist. Report concerning symptoms such as palpitations, fainting, or severe dizziness immediately. When uncertain, defer to the official label and your prescriber’s direction.

Strengths and Forms

This therapy is most commonly provided as a domperidone tablet in a 10 mg strength. Pack sizes and manufacturers may vary. Availability depends on inventory and your prescription.

Check our Gastrointestinal category for related options and updates. Strengths listed here reflect commonly published presentations; local supply can differ.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is near the next scheduled dose. Skip the missed dose if the next dose is soon. Do not double up to compensate. Consistency matters; taking doses before meals supports effectiveness aligned to labeling and prescriber guidance.

Storage and Travel Basics

Store tablets at room temperature, away from excess heat, moisture, and light. Keep them in the original container with labels intact, and out of reach of children and pets. Do not use tablets that are damaged, discolored, or past the labeled date.

For travel, keep your medication in carry-on baggage with your prescription details. A copy of your prescription and your prescriber’s information can help with security checks. Maintain your schedule when crossing time zones by planning ahead with your healthcare professional. If your itinerary involves temperature extremes, use a small protective case. As a general privacy and safety measure, our checkout is encrypted.

Benefits

This medicine can reduce queasiness and help with post-meal fullness by improving gastric emptying. It may lessen vomiting episodes and help stabilize intake when nausea has limited eating. Compared with some centrally acting options, this class can cause fewer movement-related side effects, though individual responses vary.

People often report better tolerance of meals and reduced bloating when the treatment is dosed before eating. Relief can encourage gradual return to balanced nutrition, as tolerated. Always partner with your prescriber on overall care, including diet and hydration guidance specific to your condition.

Side Effects and Safety

• Headache
• Dry mouth
• Abdominal cramps
• Dizziness or lightheadedness
• Diarrhea or constipation

Serious risks include heart rhythm changes such as QT prolongation, ventricular arrhythmias, and very rare sudden cardiac death. Risk can increase with higher doses, in older adults, with underlying cardiac disease, with electrolyte abnormalities, or when combined with interacting medicines. The treatment can raise prolactin, which may cause breast symptoms or menstrual changes. Seek urgent care for fainting, rapid or irregular heartbeat, or severe dizziness.

For a deeper dive into tolerability, see our article on Domperidone Side Effects.

Drug Interactions and Cautions

Important interactions include strong CYP3A4 inhibitors such as certain macrolide antibiotics, azole antifungals, and some HIV protease inhibitors. Many of these also prolong the QT interval, further increasing risk. Other QT-prolonging drugs, significant electrolyte disturbances, and structural heart conditions require special caution.

Discuss all medicines, supplements, and grapefruit products with your prescriber or pharmacist. Regarding lactation, domperidone breastfeeding is not an approved indication in the United States or Canada; decisions must be individualized and risk-informed. People with moderate or severe hepatic impairment should not use this treatment. If you have kidney impairment, your prescriber may adjust frequency.

What to Expect Over Time

When taken before meals as directed, some people notice steadier tolerance of food and less nausea. Effects build with consistent use and careful avoidance of interacting medicines. If symptoms persist or worsen, your prescriber may reassess the plan.

Monitoring focuses on efficacy, side effects, and any signs of cardiac issues. Your clinician may periodically review your overall regimen to ensure the therapy remains necessary. Keep a simple symptom log; short, daily notes can help inform dose timing and meal patterns.

Compare With Alternatives

Other approved options may be suitable depending on your diagnosis and history. For prokinetic therapy, clinicians sometimes consider Metoclopramide. For direct nausea control, serotonin antagonists like Ondansetron are also used in various settings. Your prescriber will weigh potential benefits and risks for your situation.

Pricing and Access

We highlight Canadian options alongside transparent details so you can discuss therapy choices with your clinician. If you want to understand the cost of domperidone compared with alternatives, review our product page for current listings. We support US shipping from Canada with clear checkout steps and encrypted payment processing. If you are seeking savings, you may also check our site’s Promotions page for periodic offers.

To see broader context for conditions treated, browse Gastrointestinal and Gastroparesis. For deeper learning, our primer on Mechanism And Benefits covers how this class supports coordinated stomach activity.

Availability and Substitutions

Supply can vary by manufacturer and lot. If an item is unavailable, your prescriber may recommend an alternative or a different dosage form. When appropriate and authorized, a domperidone generic option may be dispensed based on your prescription and local rules. We cannot promise restock dates; inventory updates are posted as they change.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with nausea or upper GI motility symptoms when a prescriber determines benefits outweigh risks. It may not suit those with cardiac disease, significant electrolyte abnormalities, moderate or severe hepatic impairment, or those on interacting therapies. Pregnant or nursing individuals should discuss potential risks and benefits with their prescriber.

To help manage overall costs, consider multi-month supplies if your prescription allows and your prescriber agrees. Setting simple refill reminders can prevent gaps in therapy. Reviewing your full medication list with a pharmacist can identify interaction risks that might otherwise lead to wasted fills. Category pages like Nausea And Vomiting can help you compare treatment classes under clinician guidance.

Questions to Ask Your Clinician

• Diagnosis clarity: what is driving my symptoms?
• Therapy goals: which outcomes would indicate success?
• Dose plan: how long should I stay on the lowest effective dose?
• Safety: do my other medicines increase cardiac risk?
• Monitoring: what symptoms should prompt urgent evaluation?
• Alternatives: when might a different class be better?
• Deprescribing: how will we assess ongoing need over time?

Authoritative Sources

For official information and safety communications, see:

• Health Canada Drug Product Database
• Health Canada DPD Search
• Manufacturer Product Information (via DPD)

Ready when your prescription is set? You can place your order with prompt, express shipping and US shipping from Canada. This page is informational and not a substitute for professional medical advice; always follow your prescriber’s instructions and the official label.