Entresto® Tablets for Heart Failure

Entresto® is a prescription medicine for certain adults with chronic heart failure. This page explains how it works, who it may suit, and how to use it, with US delivery from Canada and ways to save without insurance.

What Entresto Is and How It Works

Entresto combines sacubitril and valsartan, a dual approach known as an angiotensin receptor neprilysin inhibitor. As Sacubitril Valsartan tablets, it helps relax blood vessels and reduce hormones that strain the heart. This treatment may lower the chance of cardiovascular death and heart failure hospitalizations when used as directed on the label. It is usually taken instead of an ACE inhibitor or ARB in appropriate patients.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

It works by blocking neprilysin to increase beneficial peptides while valsartan blocks angiotensin II at the receptor. Together, the medicine can reduce afterload and help your heart work with less stress. Your prescriber will decide if this therapy fits into your overall heart failure plan.

Who It’s For

This medicine is approved for adults with chronic heart failure and reduced ejection fraction. It may be used in place of an ACE inhibitor or ARB when appropriate. People who have ever had angioedema with an ACE inhibitor or ARB should not use this product. Do not take it with aliskiren if you have diabetes. Avoid use during pregnancy. Discuss liver or kidney problems, high potassium, dehydration, or low blood pressure with your clinician before starting.

For broader context on heart conditions and care, see Heart Failure and our Cardiovascular category for related therapies and guidance.

Dosage and Usage

Tablets are swallowed twice daily, with or without food. Your clinician selects a starting dose and may adjust over time based on response and tolerability. If you are switching from an ACE inhibitor, a washout period is required before starting this therapy. Follow the label and your prescriber’s directions closely.

When used in standard practice, Sacubitril Valsartan 49/51 mg twice daily is a common intermediate step on the way to a labeled target dose, when tolerated. Do not change your dose on your own. If questions arise about timing, meals, or other medicines you take, ask your healthcare professional to review your schedule.

Strengths and Forms

The treatment comes as film-coated tablets in multiple strengths to support careful titration. Availability may vary by pharmacy.

• Entresto 24/26 mg tablets
• 49/51 mg tablets
• 97/103 mg tablets

Colors and tablet shapes are set by the manufacturer to help differentiation among strengths. Your pharmacy label will list the strength you were prescribed.

Missed Dose and Timing

If you miss a dose, take it when you remember on the same day. If it is close to your next scheduled dose, skip the missed one and resume your regular schedule. Do not double up. Try pairing doses with daily routines, like morning and evening brushing, to help consistency.

Storage and Travel Basics

Store tablets at room temperature in a dry place and keep them in the original container with the label intact. Protect from excess moisture and keep out of reach of children and pets. When traveling, carry the medicine in your hand luggage along with your prescription information. Keep a medication list, and plan refills ahead of time if you will be away. If you have questions about pill organizers or splitting routines during travel, ask your clinician or pharmacist for label-consistent guidance.

Benefits

This therapy may reduce the risk of cardiovascular death and heart failure hospitalizations compared with older regimens in appropriate patients. Many people appreciate a twice-daily tablet schedule. It can be combined with other heart failure therapies, such as beta blockers and diuretics, under a clinician’s direction.

Side Effects and Safety

• Low blood pressure symptoms
• Cough or dizziness
• High potassium
• Kidney function changes
• Fatigue or headache

Serious but less common risks include angioedema, acute kidney injury, and marked hyperkalemia. Seek urgent care for swelling of the face, lips, tongue, or throat, or trouble breathing. Risk of hypoglycemia may rise when used with insulin or sulfonylureas in some situations, largely due to improved cardiovascular status and changes in metabolic needs; monitor with your clinician if relevant.

Drug Interactions and Cautions

Do not use with an ACE inhibitor or within the required washout after one. Avoid aliskiren if you have diabetes. Potassium supplements, salt substitutes, or potassium-sparing diuretics can increase potassium. NSAIDs can affect kidney function, especially with dehydration. Lithium levels may rise with concurrent ARB therapy. Alcohol can amplify dizziness or low blood pressure effects. If you take other heart medicines, ask your clinician to review your full list. For additional background on related therapies, see Lisinopril 10 Mg and Fosinopril Benefits.

What to Expect Over Time

Many people notice blood pressure effects early, while heart failure outcomes are monitored over longer periods through clinic visits and lab tests. Your clinician may check kidney function and potassium regularly and adjust other medicines, such as diuretics, as needed. Keeping a symptom diary, tracking daily weight, and following sodium and fluid guidance can support your care plan. For context on adjunct therapies that affect outcomes, you can read Jardiance For Heart Failure and Dapagliflozin Readmissions.

Compare With Alternatives

Different medicines play complementary roles in heart failure care. Loop diuretics help manage fluid overload, while ARNI therapy targets neurohormonal pathways. Two options we carry that clinicians often pair with or consider alongside other heart therapies include:

• Lasix for diuretic management when fluid relief is needed
• Vascepa for cardiovascular risk reduction in select patients

These are not direct substitutes for this medicine, but they may be part of a broader plan led by your prescriber. Explore our Cardiovascular category for additional options.

Pricing and Access

Canadian pharmacies often offer competitive rates compared to local cash prices. If you are comparing options, you can review Entresto price without insurance alongside generic and brand choices where available. We present current pricing clearly so you can plan your out-of-pocket spending. For Canadian pricing details and US shipping from Canada, view the product page and follow the checkout steps. See current offers on our Promotions page when available.

For transparency, we provide clear totals at checkout with taxes and fees where applicable. Your information is protected with encrypted checkout.

Availability and Substitutions

Supply can vary by strength and pack size. If a specific option is temporarily unavailable, your prescriber may recommend a comparable alternative from the same class or a different class as appropriate. We cannot guarantee restock dates, but we will display live availability on the product page.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults with chronic heart failure and reduced ejection fraction who need a comprehensive regimen. It may not be appropriate for those with prior angioedema, pregnancy, or certain kidney or liver conditions. Ask your prescriber about a 30-day or Entresto 90 day supply to reduce pharmacy trips and help adherence. Multi-month fills can also lower per-fill service fees. Set refill reminders, align refills with appointments, and bring an updated medication list to each visit for review.

If you prefer consistent country-of-origin sourcing, you can filter by Canada.

Questions to Ask Your Clinician

• Is this therapy appropriate for my heart failure stage and symptoms?
• How should I time this medicine with my diuretic and beta blocker?
• What blood tests and blood pressure targets will you monitor?
• How do we watch for high potassium and kidney changes?
• What signs of angioedema need emergency care?
• Should I avoid certain over-the-counter pain relievers or supplements?
• When should we reassess dose and overall regimen?

Authoritative Sources

Novartis Entresto

FDA DailyMed

Health Canada DPD

Order Order Entresto online from Border Free Health for temperature-controlled handling when required and prompt, express shipping. Always use this medicine under a prescriber’s care.