Movantik® Tablets for Opioid-Induced Constipation

Movantik is a prescription tablet used to treat constipation caused by long-term opioid therapy in adults. It targets bowel receptors to help restore regular movements while preserving opioid pain control. We offer US delivery from Canada, with options that can fit your budget without insurance.

What Movantik Is and How It Works

Movantik® contains naloxegol, a peripherally acting mu-opioid receptor antagonist. It blocks opioid effects in the gut without crossing into the brain at usual doses. That helps relieve constipation symptoms while maintaining pain relief from your opioid medication. The mechanism centers on reduced opioid binding in intestinal tissue, which can improve stool frequency and ease straining.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Label sources note it is intended for adults with chronic non-cancer pain who develop opioid-induced constipation. It is not a general laxative. If you have known or suspected gastrointestinal obstruction, your prescriber will usually avoid this therapy because of perforation risk. See our condition guide on Opioid-Induced Constipation for context on causes and options.

Who It’s For

This medicine is indicated for adults taking opioids where constipation persists despite basic measures. It may be used when lifestyle changes and over-the-counter laxatives are not enough. Movantik uses in the label focus on chronic non-cancer pain; it is not for cancer-related pain management unless directed by a clinician. People with severe stomach or bowel problems, or those at high risk for gastrointestinal perforation, should generally avoid it. Discuss pregnancy, breastfeeding, and any history of bowel surgery with your healthcare professional.

Dosage and Usage

Follow directions from your prescriber and the official label. Typical administration is once daily on an empty stomach, at least one hour before the first meal or two hours after. Take the tablet whole with water. Do not crush or split unless the label provides specific instructions for mixing with water as an alternative. Your prescriber may start with a lower dose in certain kidney conditions or if you use interacting medicines.

Pause routine laxatives at the start unless your clinician advises otherwise. If constipation does not improve after a few days, your prescriber may recommend adding back a bowel regimen. Avoid grapefruit or grapefruit juice because it can affect drug levels. If you are unsure about timing with other medicines, ask your pharmacist. For administration questions, check reputable sources or the Movantik how to take section of official materials.

Strengths and Forms

Naloxegol is supplied as oral tablets in two strengths commonly referenced in labeling: 12.5 mg and 25 mg. Availability can vary by manufacturer and country.

These Naloxegol tablets are intended for once-daily use. Not all package sizes are listed in every market. Your prescriber will choose a strength that fits your treatment plan and medical history.

Missed Dose and Timing

If you miss a dose, take the next dose at the usual time on the following day. Do not take two doses at once. If vomiting occurs soon after taking a dose, do not repeat the tablet; resume the regular schedule the next day. Consistent timing helps maintain steady effect. If your opioid therapy is stopped, your clinician may determine that this treatment is no longer needed.

Storage and Travel Basics

Store at room temperature in the original container with the label intact. Keep the bottle tightly closed and away from moisture. Protect from excessive heat or light. Place out of reach of children and pets. When traveling, carry the prescription-labeled container in your hand luggage. Keep a medication list and contact information for your prescriber. If you cross time zones, take the dose based on your new local morning routine so it stays on an empty stomach. As a general security measure, we use encrypted checkout; handling may include temperature-controlled handling when required.

Benefits

This therapy targets the cause of opioid-related constipation in the gut. It can improve stool frequency, reduce straining, and ease abdominal discomfort. Because action is peripheral, it is designed to preserve opioid pain control. Once-daily dosing and tablet form support a simple routine. Your clinician can combine it with dietary fiber, hydration, and activity plans for broader bowel care.

Side Effects and Safety

Common Naloxegol side effects include abdominal pain, diarrhea, nausea, flatulence, vomiting, and headache. Many effects are mild and tend to lessen after the first few days as your body adjusts.

• Stomach pain or cramps
• Diarrhea or loose stools
• Nausea or vomiting
• Gas and bloating
• Headache

Serious risks are uncommon but can occur. Stop the medicine and seek urgent care if you notice severe or persistent abdominal pain, signs of gastrointestinal perforation, severe diarrhea with dehydration, or allergic reactions such as rash, swelling, or difficulty breathing. Opioid withdrawal-like symptoms may occur in rare cases, such as sweating, chills, abdominal pain, anxiety, irritability, or yawning. Those with known or suspected bowel obstruction should not start therapy. If you take insulin or other medicine that can lower blood sugar, continue your usual monitoring as advised by your prescriber.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements you use. Strong CYP3A inhibitors (for example, clarithromycin or ketoconazole) can raise naloxegol levels and are generally avoided. Moderate inhibitors may require dose adjustments. CYP3A inducers (such as rifampin) can reduce effectiveness. Avoid grapefruit and grapefruit juice. Using other opioid antagonists at the same time, such as naltrexone, may increase the chance of withdrawal-like symptoms.

Medicines that cause constipation, including anticholinergics or antiemetics like Ondansetron, can counteract progress; your care team may tailor your regimen. As part of opioid safety planning, some households keep Narcan Nasal Spray for emergencies; discuss this with your prescriber if appropriate. For pain-related context, see our explainer on Neuropathic Pain.

What to Expect Over Time

Response varies. Some people notice earlier, more regular bowel movements after starting. Others need a few days and supportive measures like hydration, fiber, and gentle activity. Take the tablet at the same time each morning on an empty stomach for best consistency. If results are not satisfactory, your prescriber may adjust the approach or add a complementary bowel regimen. Keep a simple stool diary to share with your healthcare professional at follow-up visits.

Compare With Alternatives

Other peripherally acting mu-opioid receptor antagonists, such as methylnaltrexone or naldemedine, are approved for opioid-induced constipation. Chloride channel activators like lubiprostone are also used in some cases. Choice depends on your opioid dose, medical history, and prior response to laxatives. Explore related options within our Gastrointestinal section and talk with your prescriber about the best fit.

Pricing and Access

We source Canadian pharmacy inventory with transparent pricing and US fulfilment. You can review availability, compare strengths, and request your prescriber to send a prescription to us. If you are comparing options, you can estimate Movantik price without insurance against typical local rates. Ordering is straightforward: add the item to your cart, upload your script, and we will coordinate verification with your clinician. Ships from Canada to US with clear tracking.

Availability and Substitutions

Stock can vary. If your preferred brand is unavailable, a prescriber may consider a therapeutically appropriate alternative from the same class. Generic status can differ by market. Ask whether a Naloxegol generic is an option for your prescription, or if a different agent from this class better suits your history.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults on long-term opioids who have not responded to stool softeners or stimulant laxatives alone. Those with bowel obstruction or high perforation risk should avoid it. If you have significant kidney or liver issues, your prescriber will weigh risks and benefits and may adjust the plan.

• Multi-month fills: 60- or 90-day supplies can reduce per-tablet costs.
• Streamlined refills: set calendar reminders so you do not run out.
• One prescriber: coordinate all opioid and bowel care with one clinic.
• Lifestyle support: hydration, fiber, and activity remain important.
• Check interactions: review new medicines and supplements promptly.

Questions to Ask Your Clinician

• Is this class right for my type of constipation?
• How should I time the dose with food and other medicines?
• Which warning signs mean I should stop and call you?
• Could my other treatments make constipation worse?
• What is the plan if this option does not work well?
• How long should I try it before we reassess?
• Are there cost-saving options for a longer supply?

Authoritative Sources

See the official FDA DailyMed database for label details and updates, including Movantik prescribing information. Manufacturer resources may be available at movantik.com. Health Canada’s Drug Product Database also lists naloxegol entries: DPD. For general safety topics, you can also review our guide on Side Effects.

Ready to proceed? Add to cart and upload your prescription for prompt, express shipping with US shipping from Canada. This information is educational and not a substitute for advice from your healthcare professional.