Diprivan® Injection for General Anesthesia

Propofol is an intravenous anesthetic used for induction and maintenance in controlled settings. This page helps your facility evaluate Propofol injection options, compare presentations, and plan storage and handling, even without insurance, with US delivery from Canada. You will find label-aligned guidance so your team can place an informed order.

What Propofol Is and How It Works

Propofol is a short-acting sedative–hypnotic used for General Anesthesia and Sedation in monitored settings. Branded formulations such as Diprivan® deliver rapid onset and quick recovery because the medicine enhances GABA-mediated inhibitory neurotransmission in the central nervous system. Facilities value the predictable depth of hypnosis, which clinicians titrate to the procedure’s needs.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Clinically, teams use this treatment for smooth induction, then continue with a titrated infusion to maintain the desired anesthesia depth. The lipid emulsion vehicle supports quick distribution and clearance. When listed as Propofol 10 mg/mL, the concentration reflects the standardized emulsion strength found across most vials.

Who It’s For

This medicine is indicated for induction and maintenance of general anesthesia in adults and in pediatric patients where approved, and for sedation of intubated, mechanically ventilated adults in the ICU. It is administered only by clinicians trained in anesthesia who can provide airway support and hemodynamic monitoring. It is not appropriate for self-administration.

People with a known hypersensitivity to propofol or formulation components should avoid it. Many emulsions include soybean oil and egg lecithin; consider ingredient allergies carefully. Caution is advised in patients with hemodynamic instability, disorders of fat metabolism, or those at risk for elevated triglycerides during prolonged infusions. Pediatric ICU sedation may have specific restrictions; follow the official label.

Dosage and Usage

Administration is intravenous. Clinicians typically give small, incremental boluses for induction, then adjust a continuous infusion to maintain anesthesia. For procedural sedation, lower infusion rates and careful titration are used, with full monitoring and resuscitation equipment immediately available.

Strict aseptic technique is essential. Prepare lines and syringes immediately before use. Discard partially used vials according to local protocols. Packaging size, such as a Propofol 20 mL vial, may be chosen based on case volume and anticipated wastage controls.

Strengths and Forms

Propofol is supplied as a sterile oil-in-water emulsion for IV use. The most common strength is 10 mg/mL. Vials are usually single-use. Availability varies by manufacturer and market.

• Propofol 50 mL vial
• 20 mL single-use vials commonly used for induction
• 100 mL presentations used in some maintenance settings

Brand and generic presentations exist from multiple manufacturers. Local stock and labeling may differ; verify the specific package insert with each shipment.

Missed Dose and Timing

Propofol is given under continuous clinical supervision. If a dose or infusion is interrupted during a case, the anesthesia professional will re-establish sedation as appropriate. Patients should not attempt to take or adjust this therapy outside a monitored medical setting.

Storage and Travel Basics

Store vials at controlled room temperature as specified by the label, and protect from freezing and excessive heat. Keep in original packaging until preparation to preserve lot and expiry information. Emulsions support microbial growth; use sterile technique and discard unused portions per the label’s time limits.

For transport between clinical sites, keep stock secured and upright, and follow institutional policies. Carry procurement documentation if traveling across facilities. For online orders, temperature-controlled handling when required helps maintain product integrity during transit. Keep all medicines out of reach of children.

Benefits

This anesthetic offers reliable, rapid onset and short duration, enabling smooth induction and quick emergence. Clinicians can titrate depth precisely for ambulatory and inpatient procedures. Many teams appreciate the favorable recovery profile and the ability to pair it with opioids or other agents to meet case-specific needs.

Side Effects and Safety

• Low blood pressure or slowed heart rate
• Temporary apnea or reduced breathing
• Pain or burning at the injection site
• Nausea, vomiting, or dizziness
• Rash, flushing, or pruritus
• Increased triglycerides during prolonged infusions

Serious but less common risks can include severe hypotension, arrhythmias, anaphylaxis, infection from contamination, and propofol infusion syndrome during prolonged high-dose ICU use. Clinicians monitor airway, ventilation, circulation, and lab values as indicated. For allergic symptoms that occur perioperatively, adjunctive agents such as Diphenhydramine Injection Vial may be used per institutional protocols. For procedure-related nausea, options like Metoclopramide may be considered by the prescriber.

Drug Interactions and Cautions

Concomitant CNS depressants, including benzodiazepines, opioids, and inhalational anesthetics, can increase sedation and cardiorespiratory effects. Alcohol has additive CNS depression. Adjustments and close monitoring are routine when combining agents. This treatment does not provide analgesia; pairing with analgesics is common during surgery. Avoid extravasation and intra-arterial administration. Not for spinal or epidural use.

What to Expect Over Time

Induction is typically rapid, with depth advancing smoothly under clinician control. Recovery after short cases is generally quick when infusions stop, though some drowsiness or dizziness can persist. During prolonged ICU infusions, teams monitor triglycerides, liver function, and acid–base status. Expect routine vigilance for hypotension and respiratory depression throughout use.

Compare With Alternatives

Clinicians may consider etomidate for hemodynamic stability or ketamine when dissociative anesthesia and preserved airway reflexes are preferred. Dexmedetomidine can be used for ICU sedation without general anesthesia. The choice depends on the procedure, comorbidities, and institutional protocols, and Diprivan may be selected when rapid titration and predictable emergence are priorities.

Pricing and Access

Facilities use this page to review formulary options and current Propofol price before submitting a prescription. Our Canadian partners support US shipping from Canada with transparent selection of vial sizes. Pricing reflects Canadian sourcing; taxes or dispensing fees may vary by order. If you are watching budget impact, see current offers on our Promotions page. Checkout is encrypted, and professional-use orders require valid prescriptions.

To compare options, review sizes, brands, and availability, then add the appropriate vials to your cart to see live costs and fulfilment details.

Availability and Substitutions

Supply can vary by manufacturer and size. If a specific vial is unavailable, a prescriber may recommend a comparable presentation or an alternative anesthetic from your formulary. We cannot provide restock dates; please check back or consider other sizes suitable for your clinical workflow.

Patient Suitability and Cost-Saving Tips

Good candidates are patients undergoing procedures where an anesthesia professional can provide continuous monitoring. It is not suitable for individuals with known hypersensitivity to the drug or emulsion ingredients. For facilities managing budgets, consider ordering multi-month quantities within storage limits to reduce per-shipment costs, and align vial sizes with case volume to minimize waste. Evaluate your Propofol cash price against institutional benchmarks and document any savings for pharmacy and therapeutics review. Use refill reminders so your stock replenishes before scheduled blocks.

Questions to Ask Your Clinician

• Procedure goals: what depth of anesthesia is planned?
• Agent selection: why choose this sedative–hypnotic over alternatives?
• Monitoring plan: what hemodynamic and respiratory checks are used?
• Adjuncts: which analgesics or antiemetics will accompany this therapy?
• Recovery: how will emergence be assessed and supported?
• ICU use: what labs are monitored during prolonged infusions?

Authoritative Sources

Fresenius Kabi Propofol Product Page

FDA DailyMed: Propofol Injection

Health Canada Drug Product Database

Ready to source? Start your order with BorderFreeHealth for prompt, express shipping and temperature-controlled handling when required. This information is not a substitute for the full prescribing information or clinical judgment.