Taro-Tofacitinib XR® Extended-Release Tablets for Rheumatoid Arthritis

Taro-Tofacitinib XR is a once-daily JAK inhibitor tablet for immune-mediated arthritis. This page explains how the treatment works, who it suits, and how to use and store it safely.

What Taro-Tofacitinib XR Is and How It Works

This medicine contains tofacitinib, a Janus kinase (JAK) inhibitor. It helps reduce overactive immune signaling that drives joint inflammation and tissue damage. The XR tablet is taken once daily and designed for steady release through the day. US delivery from Canada is available to support access. For those paying out of pocket, we also address Taro-Tofacitinib XR® without insurance options.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

As a targeted immunomodulator, the therapy may lower inflammatory markers and improve joint symptoms over time. It is not a steroid or biologic. It is an oral alternative that may be considered after or alongside conventional disease-modifying options. Explore related conditions in our Immunology category.

Who It’s For

The XR tablet is used in adults with moderate to severe rheumatoid arthritis who have had an inadequate response or intolerance to one or more disease-modifying drugs. It is also used for active psoriatic arthritis in adults when other options have not controlled symptoms well. Some regions include ulcerative colitis in tofacitinib labeling; dosing and tablet type for that condition differ and should follow the official product label and prescriber direction.

Patients with a history of serious or recurrent infections, certain cancers, blood clots, or major cardiovascular risk may not be candidates. Discuss risks if you are 50 or older with cardiovascular risk factors. Avoid use with other potent immunosuppressants or biologic DMARDs. For condition-specific guidance, see Rheumatoid Arthritis, Psoriatic Arthritis, and Ulcerative Colitis.

In some cases, people ask about generic Xeljanz XR 11 mg as a comparable class option. Your prescriber will determine the appropriate product and schedule.

Dosage and Usage

Follow your prescriber and the official label. For arthritis indications, the extended-release formulation is generally taken once daily. Swallow the tablet whole with liquid. Do not split, crush, or chew. You may take it with or without food. If you also take other therapies for arthritis, your clinician may coordinate timing to reduce stomach upset and simplify routines.

A lower dose may be advisable in certain kidney or liver impairment cases, or when used with strong CYP3A4 inhibitors. Conversely, strong CYP3A4 inducers may reduce exposure. Do not adjust on your own; your prescriber will decide.

For labeling contexts that use immediate-release tablets, schedules differ. Ulcerative colitis regimens and maintenance plans can vary by country and product. When uncertain, defer to the package insert. One labeled schedule reference is Tofacitinib extended-release 11 mg for specific adults with arthritis, but confirm details with your clinician.

Strengths and Forms

The product is supplied as an extended-release oral tablet. Commonly referenced strength includes Tofacitinib XR 11 mg tablets. Availability may vary by pharmacy and region. Packaging and tablet appearance can differ between manufacturers.

Missed Dose and Timing

If you miss a dose, take it when you remember the same day. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. Aim for a consistent daily time to help adherence.

Storage and Travel Basics

Store tablets at room temperature as directed on the label. Keep the bottle closed tightly and protect it from excessive moisture. Do not store in a bathroom. Keep out of reach of children and pets. When traveling, carry your medicine in original packaging with your prescription details. Place it in your hand luggage if flying. If crossing borders, bring a copy of your prescription or a medication list. Your storage plan should limit heat and direct sunlight exposure during trips.

Some products require special handling; our pharmacies use encrypted checkout and temperature-controlled handling when required.

Benefits

This treatment is an oral option that may help reduce joint pain, swelling, and stiffness in inflammatory arthritis. Once-daily dosing can simplify routines compared with multiple daily doses or injections. As a targeted immunomodulator, it may give flexibility to patients who have not tolerated or responded to older therapies. The class may also reduce inflammatory markers that your clinician tracks over time.

Side Effects and Safety

Common effects can include upper respiratory symptoms, headache, diarrhea, nausea, and nasopharyngitis. Some people report increased cholesterol on lab testing. Shingles can occur; vaccination history may be relevant. Mild increases in liver enzymes or changes in blood counts may appear on monitoring labs.

• Common effects: headache, diarrhea, nasopharyngitis
• Respiratory symptoms: cough or cold-like signs
• Lab changes: lipids or liver enzymes may increase
• Dermatologic: possible shingles reactivation

Serious risks can include severe infections, malignancies, blood clots, gastrointestinal perforations, and major adverse cardiovascular events in higher-risk groups. The risk profile may differ based on age, smoking history, and cardiovascular factors. Seek urgent care for chest pain, shortness of breath, severe abdominal pain, or signs of infection such as fever or persistent cough. When combined with insulin or sulfonylureas this class is not known for hypoglycemia, but your full medication list still matters for safety.

Drug Interactions and Cautions

Avoid combining with strong immunosuppressants, biologic DMARDs, or potent inhibitors/inducers that significantly alter CYP3A4. Moderate CYP3A4 plus strong CYP2C19 inhibitors may also raise levels. Live vaccines should generally be avoided during therapy; discuss timing for needed immunizations before starting. Tell your clinician about all prescription, OTC, and herbal products, especially rifampin, ketoconazole, certain anticonvulsants, and St. John’s wort.

Screening for TB and viral hepatitis is commonly recommended before initiation. Report a history of clots, heart disease, or cancer. Pregnancy, trying to conceive, and breastfeeding should be discussed in advance.

What to Expect Over Time

Symptom relief may build gradually with consistent daily use. Clinicians often assess joints, function, and labs at follow-up visits to gauge response and safety. If benefits are insufficient or side effects occur, your prescriber may adjust the plan or propose a different class. Keeping a simple daily routine, using reminders, and aligning dosing with regular habits can improve adherence.

Compare With Alternatives

Extended-release tofacitinib is one oral option among several therapies used after inadequate response to conventional DMARDs. Branded tofacitinib XR is available as Xeljanz XR. An oral PDE4 inhibitor alternative for psoriatic arthritis is Otezla. These alternatives have different mechanisms, dosing, and monitoring requirements. Your clinician will match therapy to your condition, history, and risk profile.

Pricing and Access

We present Canadian pharmacy options with transparent information so you can discuss affordability with your clinician. If you are seeking Taro-Tofacitinib XR Canadian pricing, you can review our product page details and compare with local quotes. Ships from Canada to US is available for eligible prescriptions. Payment is cash-pay; insurance billing is not processed through the site.

To explore general savings approaches on arthritis therapies, see our article Treat Rheumatoid Arthritis. If you are looking for current site offers, visit Promotions. For mechanism-focused reading, you can also review Apremilast Mechanism.

Availability and Substitutions

Product availability can change by pharmacy. If this item is unavailable, your prescriber may recommend another tofacitinib formulation or a different class based on your medical needs and lab history. We do not promise restock dates. Your clinician’s advice and your insurance plan rules, if any, should guide substitution decisions.

Patient Suitability and Cost-Saving Tips

Potential candidates include adults with rheumatoid or psoriatic arthritis not controlled by conventional DMARDs. Those with high infection risk, prior clots, or certain cancers may need a different therapy. Discuss shingles vaccination before starting. Baseline labs and periodic checks are commonly used to monitor safety.

• Multi-month fills: fewer refills, often better value
• Set reminders: alarms or pillboxes help routines
• Coordinate labs: align bloodwork with follow-ups
• Review interactions: share full medication lists
• Travel ready: carry documentation and original bottle

You can schedule refills ahead to prevent gaps. Align delivery timing with travel plans and keep a buffer supply when possible, as your prescriber allows.

Questions to Ask Your Clinician

• Is an extended-release JAK inhibitor appropriate for my arthritis?
• What baseline tests and ongoing labs will you monitor?
• How do infection, cancer, clot, or heart risks affect my options?
• Should I receive any vaccines before starting this therapy?
• How will we assess benefit and when might we consider a change?
• What signs or symptoms should prompt me to call your office?

Authoritative Sources

Pfizer Xeljanz | FDA DailyMed | Health Canada DPD

Ready to proceed? You can place your order with US shipping from Canada and prompt, express shipping. This information is not a substitute for professional medical advice; always follow your prescriber and the official label.