Triumeq

Uses of Triumeq

Triumeq is a prescription medication used to treat the human immunodeficiency virus (HIV). It combines three antiviral drugs: abacavir, dolutegravir, and lamivudine. Triumeq works by preventing HIV from multiplying, helping to maintain low virus levels, minimizing immune system damage, and reducing the risk of HIV-related infections and diseases.

Triumeq is used for treating HIV-1 infections in patients aged three months and older who weigh at least 6kg. Triumeq is available in two forms: a standard tablet, which must be swallowed whole, and Triumeq PD, a dispersible tablet that can be dissolved in water, for patients under 25 kg.

Triumeq should not be used as a standalone treatment in patients who have developed resistance to certain drugs. While effective in managing HIV symptoms and progression, Triumeq is not a cure for HIV or AIDS.

Precautions and Warnings

You should not use Triumeq if you are allergic to abacavir, dolutegravir, or lamivudine or if:

• you also take dofetilide (Tikosyn);
• you have moderate or severe liver disease;
• you have a gene variation called HLA-B*5701 allele (your doctor will test you for this); or
• you have a history of allergic reactions to Combivir, Dutrebis, Epivir, Epzicom, Tivicay, Trizivir, or Ziagen.

To make sure Triumeq is safe for you, tell your doctor if you have:

• liver disease (especially hepatitis B or C);
• heart problems or risk factors such as diabetes, smoking, high blood pressure, high cholesterol; or
• kidney disease.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions if you are overweight, or if you are a woman. Ask your doctor about your risk.

You may need to have a negative pregnancy test before starting this treatment.

The active ingredients of Triumeq (abacavir, dolutegravir, or lamivudine) could harm an unborn baby if you take this medicine at the time of conception or during the first 12 weeks of pregnancy. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

If you are pregnant, use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

Dosage

Recommended Adult Triumeq Dose for HIV Infection:

• Dose: 1 Triumeq tablet once a day (600 mg abacavir, 50 mg dolutegravir, 300 mg lamivudine).

Recommended Pediatric Dose for HIV Infection:

Doses are based on weight in children and teenagers. Your child’s dose may change if the child gains or loses weight.

• 6 kg to <10 kg: three Triumeq PD tablets once daily. Total dose is 180 mg abacavir, 15 mg dolutegravir, and 90 mg lamivudine once daily.
• 10 kg to <14 kg: four Triumeq PD tablets once daily. Total dose is 240 mg abacavir, 20 mg dolutegravir, and 120 mg lamivudine once daily.
• 14 kg to <20 kg: five Triumeq PD tablets once daily. Total dose is 300 mg abacavir, 25 mg dolutegravir, and 150 mg lamivudine once daily.
• 20 kg to <25 kg: six Triumeq PD tablets once daily. Total dose is 360 mg abacavir, 30 mg dolutegravir, and 180 mg lamivudine once daily.
• 25 kg or more: one Triumeq tablet once daily. Total dose of 600 mg abacavir, 50 mg dolutegravir, and 300 mg lamivudine.

Side Effects

Common side effects:

• insomnia
• dizziness
• headache
• nausea
• gas
• diarrhea
• fatigue
• rash
• hair loss
• weight gain