Kesimpta® Injection for Relapsing Multiple Sclerosis

Kesimpta® is a prescription anti-CD20 treatment for adults with relapsing multiple sclerosis. It is taken at home after your clinician trains you on safe use. This page explains how it works, who may benefit, and how you can access US delivery from Canada, including options if paying without insurance.

What Kesimpta Is and How It Works

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Kesimpta is the brand name for ofatumumab, a monoclonal antibody that targets CD20 on B cells. It lowers specific B-cell counts, which can help reduce inflammatory activity in relapsing MS. After three starter doses, most patients continue with once-monthly maintenance doses at home.

This medicine is supplied for subcutaneous injection using either an autoinjector pen or a prefilled syringe. It is taken under the guidance of your healthcare professional, with routine monitoring for infections and immunoglobulin levels during therapy. For condition education and related options, explore our Neurology category.

Who It’s For

Kesimpta for RMS is approved for adults with relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It is not indicated for primary progressive MS. People with active infections should wait until those resolve.

Your prescriber will screen for hepatitis B before starting. Those with active HBV infection should not use this therapy. Vaccinations should be updated prior to initiation, because live vaccines are generally avoided during and after treatment until B-cell recovery.

Dosage and Usage

Standard labeling includes starter doses at week 0, week 1, and week 2, followed by maintenance every four weeks starting at week 4. Ofatumumab 20 mg/0.4 mL is injected subcutaneously into the abdomen, thigh, or outer upper arm, rotating sites each time.

Allow the device to reach room temperature out of the carton for the recommended time before use. Inspect the solution; do not use if it contains particles or is discolored. Wash hands, clean the site with alcohol, and follow the device Instructions for Use. Some patients may receive premedication if they have experienced injection-related reactions. Always follow your prescriber’s instructions and the official label.

Strengths and Forms

This treatment is available as a single-use pen and a prefilled syringe. The Kesimpta prefilled autoinjector is designed for at-home use after you are trained by a clinician. Commonly published presentation is 20 mg/0.4 mL; availability may vary by pharmacy supply.

Each device is single-use only. Do not attempt to reuse a pen or syringe. Keep the carton for storage guidance and the Instructions for Use.

Missed Dose and Timing

If you miss a dose, the general label guidance is to take it as soon as you can rather than waiting for the next scheduled date. Then continue with the monthly schedule from the new date, unless your prescriber advises otherwise. If you are unsure when to take the next dose, contact your healthcare professional for direction.

Storage and Travel Basics

Store this medicine in the refrigerator in the original carton and protect it from light. Do not freeze, and do not shake. If needed, the device may be kept at room temperature once for a limited time per the official label; do not return it to the refrigerator afterward. Keep out of reach of children.

When traveling, carry the carton in an insulated bag with coolant packs if instructed, and avoid direct contact between the device and ice. Bring your prescription details and a copy of the Instructions for Use. As a micro safety note, we use temperature-controlled handling when required.

For country-of-origin details, see Canada. Confirm current storage guidance on the latest package insert.

Pen Handling and Sharps Disposal

Use each autoinjector or prefilled syringe once. Do not attempt to recap needles. After injection, place the used device in a puncture-resistant sharps container. Follow your local rules for safe disposal. Keep sharps out of reach of children and pets. If you are unsure how to use the device, ask your clinician to demonstrate the steps and observe you during your first dose.

Benefits

This therapy targets B cells that drive inflammation in relapsing MS. After the starter period, dosing is monthly, which can fit many routines. At-home administration may reduce clinic visits and help maintain continuity during travel or schedule changes. Your prescriber will confirm if this approach fits your needs and monitoring plan.

Side Effects and Safety

• Injection-site reactions: redness, pain, itching
• Upper respiratory symptoms: sore throat, nasal congestion
• Headache or fatigue: usually mild to moderate
• Urinary tract infections: burning or frequency

Serious risks can include severe infections, reductions in immunoglobulin levels, and rare neurological complications. Hepatitis B reactivation has been reported with anti-CD20 therapies; screening is required before starting. Progressive multifocal leukoencephalopathy has been reported with other immunosuppressants; clinicians monitor for new neurological symptoms. Tell your prescriber about any fever, persistent cough, shingles, or unusual weakness. Avoid live vaccines during and after therapy until your healthcare professional confirms it’s safe.

For a patient-friendly discussion of injectable MS therapies, you can also read Copaxone Side Effects.

Drug Interactions and Cautions

Tell your clinician about all medicines, supplements, and vaccines. Live or live-attenuated vaccines are generally avoided during treatment and for a period afterward. Other immunosuppressants may raise infection risk when combined. If you are pregnant, planning pregnancy, or breastfeeding, discuss potential risks and timing of vaccination with your prescriber before starting.

What to Expect Over Time

Most patients learn self-injection techniques with support from a healthcare professional. Injection reactions are usually mild and tend to lessen after the first doses. Your clinician may check immunoglobulin levels and watch for infections during routine visits. Expect regular follow-up to review disease activity, tolerability, and adherence.

Consistency matters with monthly dosing. Consider using reminders, a calendar, or pairing the dose with a monthly date that is easy to remember. Travel plans should include refrigeration arrangements and a note from your prescriber if you are carrying devices.

For broader brain health resources and awareness, see Brain Health.

Compare With Alternatives

Several disease-modifying therapies are used for relapsing MS. Oral sphingosine-1-phosphate modulators may suit those preferring tablets; see Mayzent for reference. An injectable glatiramer acetate option may be considered for some patients; see Copaxone 40mg Ml Prefilled Syringe. Your prescriber will compare mechanisms, monitoring needs, and your medical history to select a therapy.

Pricing and Access

We offer Canadian pricing with transparent checkout and U.S. pharmacist support from partner pharmacies. If you are exploring options for high-cost therapies, our team can explain how international fulfillment works and what documentation is needed. Ask about current stock and any access programs relevant to your prescription.

If you are paying as self pay, you can still review the total before placing an order. For occasional savings opportunities, check Promotions. We provide US shipping from Canada and coordinate with your prescriber to verify the order.

Availability and Substitutions

Supply can vary. If this product is unavailable, your prescriber may recommend an alternative therapy with a different mechanism or schedule. Pharmacists will not substitute biologics without explicit authorization from your clinician. There is no generic ofatumumab product approved for this indication at this time.

Patient Suitability and Cost-Saving Tips

This treatment may fit adults who can self-inject, maintain regular monitoring, and prefer a monthly schedule after the starter phase. It may not suit those with active infections, uncontrolled chronic infections, or a history that raises specific risks discussed with their clinician.

• Multi-month fills: reduce trips and help maintain supply
• Calendar planning: align doses with an easy monthly date
• Travel prep: pack cooling materials and documents
• Refill reminders: set alerts one to two weeks ahead
• Insurance review: discuss coverage timing and prior authorizations
• Budget review: ask about options for self pay if needed

Questions to Ask Your Clinician

• Is this B-cell therapy appropriate for my MS subtype?
• What monitoring and labs will I need during treatment?
• How should I manage vaccines before starting?
• What signs of infection should prompt a call?
• Can you review the first injection steps with me?
• How should I plan storage for travel days?
• What are the options if I miss a monthly dose?

Authoritative Sources

Manufacturer Prescribing InformationFDA DailyMed: OfatumumabHealth Canada Drug Product Database

Ready to proceed? You can place your order with BorderFreeHealth for Ships from Canada to US and prompt, express shipping. Prescription required. This content is for general information and does not replace medical advice.