Trazodone Tablets for Depression

Trazodone is a prescription antidepressant used to treat major depressive disorder. This page explains key uses, safety considerations, and how you can access it, including typical options if you pay without insurance.

What Trazodone Is and How It Works

Trazodone is a serotonin antagonist and reuptake inhibitor that helps balance serotonin activity in the brain. It is the generic form of Desyrel®, and the active ingredient is Trazodone HCl. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing. We offer US delivery from Canada so you can request supply through our platform with your prescriber’s authorization.

This medicine works by blocking certain serotonin receptors while modestly inhibiting serotonin reuptake. That dual effect may improve mood and reduce anxiety symptoms for some adults. Sedation can occur, which is why many patients take doses in the evening.

Who It’s For

This treatment is indicated for adults with major depressive disorder. Clinicians may also use it as adjunct therapy in patients who do not fully respond to a first antidepressant. Some prescribers use it for sleep maintenance problems, though that is an off-label use. Explore related support on our Depression page and broader options within Mental Health.

It may not be appropriate if you have taken an MAOI within the last 14 days, have known hypersensitivity to trazodone or formulation components, experienced priapism in the past related to serotonergic drugs, or have certain rhythm disorders. Discuss your history with a healthcare professional before use.

Dosage and Usage

Use this medicine exactly as directed by your prescriber and according to the approved label. Immediate-release tablets are often taken in divided doses with food or a light snack to reduce stomach upset. Extended-release tablets are generally taken once daily, usually at bedtime. Swallow extended-release tablets whole; do not crush or chew.

Try to take doses at the same time each day. If daytime drowsiness is troublesome, your clinician may suggest moving doses toward evening. Avoid alcohol and other sedatives while you are adjusting because additive effects may occur. If you have questions about your individual schedule, consult the official label or your prescriber.

Strengths and Forms

Availability can vary by pharmacy and manufacturer. Common presentations include:

• Immediate-release tablets: 50 mg, 100 mg, 150 mg, 300 mg
• Extended-release tablets: 150 mg, 300 mg

Check the current listings to see which pack sizes are offered. For a deeper overview of safety topics, see our article Trazodone Desyrel Side Effects Interactions Uses.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is close to your next scheduled dose. If it is near the next time, skip the missed dose and resume your usual plan. Do not double up to make up a missed dose. Consistency supports steady symptom management.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from moisture and direct light. Keep them in the original child-resistant container with the label intact. When traveling, carry your medication in hand luggage with a copy of your prescription and your prescriber’s information. If crossing borders, keep the labeled bottle to streamline screening. Secure storage protects children and pets.

Pen Handling and Sharps Disposal

This product is supplied as oral tablets. Pen handling and sharps disposal do not apply.

Benefits

This therapy is an established antidepressant in adults. It may help improve mood, reduce anxiety symptoms, and support sleep maintenance in some patients under a clinician’s guidance. Once-daily extended-release options can simplify routines, while immediate-release strengths allow flexible titration when clinically appropriate.

Side Effects and Safety

• Common effects: drowsiness, dizziness, dry mouth
• GI effects: nausea, constipation, abdominal discomfort
• Neurologic: headache, blurred vision
• Cardiovascular: orthostatic dizziness

Serious but less common risks include serotonin syndrome with other serotonergic drugs, prolonged or painful erections, and rhythm changes. Worsening depression or suicidal thoughts can occur, especially at the start of treatment or with dose changes. Seek urgent care for chest pain, fainting, signs of serotonin syndrome, or priapism.

If you also use insulin or sulfonylureas, hypoglycemia risk is not typically increased by this antidepressant class, but discuss your full regimen with your prescriber to coordinate monitoring.

Drug Interactions and Cautions

High-level interactions include MAOIs, other serotonergic agents (SSRIs, SNRIs, triptans, linezolid, methylene blue), strong CYP3A4 inhibitors or inducers, and CNS depressants such as alcohol, benzodiazepines, or opioids. Using cannabis may increase sedation. Combining with anticoagulants or antiplatelets can raise bleeding risk. Caution is advised with drugs that prolong the QT interval or lower sodium.

Tell your prescriber about all medicines, vitamins, and supplements. Review the interaction list on the official label if you add or remove therapies. For combination questions, our article Can I Take Trazodone And Wellbutrin Together A Comprehensive Guide may help your discussion.

What to Expect Over Time

Some people notice sedation the first few days. Mood effects may take time and steady adherence. Track your sleep, energy, and concentration in a journal to share with your clinician at follow-up. If side effects appear, do not stop abruptly without guidance. Many patients take evening doses to reduce daytime drowsiness.

For broader context on options, see Top 5 Medications For Depression Understanding Your Options. If anxiety symptoms are prominent, you may also find Social Anxiety Disorder Medication What You Need To Know useful when speaking with your prescriber.

Compare With Alternatives

For sleep-predominant symptoms, some clinicians consider short-term hypnotics. One option we carry is Zopiclone. For mood stabilization when indicated, prescribers may use adjuncts such as Seroquel® XR. Your clinician will choose based on diagnosis, history, and tolerability.

Pricing and Access

See current options and compare the Trazodone price across available pack sizes. Canadian pricing with US shipping from Canada can reduce cash-pay costs for some orders. You can review strengths and quantities before you add to cart and upload your prescription.

Savings CTA: Review listed generics and see how Canadian sources may help your budget. Pricing CTA: Check in-cart details to view current availability and total before checkout.

Availability and Substitutions

Supply can vary by strength, manufacturer, and pack size. If a specific option is out of stock, a prescriber may recommend an alternative or a different strength. We also support requests for Trazodone from Canada when listed strength options are available.

Patient Suitability and Cost-Saving Tips

This treatment may suit adults who need a serotonin-based antidepressant and can take evening doses. It may not suit those with significant heart rhythm disorders, severe liver disease, or a history of drug-induced priapism. Always discuss pregnancy or breastfeeding plans with your healthcare professional.

• Multi-month fills: fewer refills, steadier supply
• Evening dosing: may limit daytime drowsiness
• Take with food: helps stomach tolerance
• Refill reminders: set alerts to stay on track
• Keep one pharmacy: simplifies interaction checks

Consider comparing strengths and manufacturers to match your prescriber’s plan and your budget. Our encrypted checkout keeps your details protected.

Questions to Ask Your Clinician

• Best time to take: morning vs bedtime recommendations
• Dose form choice: immediate vs extended-release
• Interaction risks: other antidepressants, triptans, or supplements
• Driving safety: drowsiness and situational precautions
• Alcohol guidance: what to avoid during initiation
• Stopping plan: how to taper if needed
• Monitoring: what symptoms to track between visits

Authoritative Sources

FDA DailyMed: Trazodone Hydrochloride Tablets

Health Canada DPD: Trazodone

FDA Prescribing Information: Desyrel

You can buy Trazodone online with prompt, express shipping. Ships from Canada to US. This information is not a substitute for medical advice; always follow your prescriber’s guidance and the approved label.