Xigduo® Tablets for Type 2 Diabetes

Xigduo is a prescription combination for adults with type 2 diabetes. This medicine pairs dapagliflozin with metformin to improve glucose control, even if you pay without insurance.

What Xigduo Is and How It Works

With US delivery from Canada, Xigduo® supports blood sugar management through two complementary actions. Dapagliflozin helps your kidneys remove excess glucose in urine. Metformin reduces liver glucose production and improves insulin response. Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

Some patients use Xigduo XR tablets when an extended-release option fits their plan. This combination is typically used along with diet and physical activity. Always follow your prescriber’s instructions and the official label for details.

Who It’s For

This treatment is for adults with type 2 diabetes who need additional control beyond lifestyle changes. It may be started alone or added to other diabetes therapies. It is not for type 1 diabetes or for diabetic ketoacidosis.

People with severe kidney disease or on dialysis should not use this medicine. Those with liver problems, dehydration, low blood pressure, or heavy alcohol use may need special caution. Discuss pregnancy and breastfeeding with your prescriber. Review the condition overview in Type 2 Diabetes for context.

Dosage and Usage

Extended-release tablets are generally taken once daily with food, often with the evening meal to reduce stomach upset. Swallow tablets whole; do not crush, split, or chew. Your prescriber may start low and adjust based on tolerance and goals. Some regimens reference Dapagliflozin Metformin XR 10mg 1000mg according to labeling; your exact dose may differ. Read the Patient Information provided with each fill.

Hydration matters. This medicine can increase urination, so maintain fluid intake unless your prescriber advises otherwise. If you also use insulin or a sulfonylurea, watch for low blood sugar and follow your clinician’s guidance.

Strengths and Forms

This combination is supplied as film-coated tablets, including extended-release presentations. A commonly referenced strength is Xigduo XR 10 mg 1000 mg. Other presentations may exist, and availability can vary by market and stock.

Missed Dose and Timing

If you miss a dose, take it when you remember that same day. If it is almost time for your next dose, skip the missed dose. Resume your regular schedule. Do not take two doses at once. Consistent timing helps reduce stomach effects and supports steady glucose control.

Storage and Travel Basics

Store tablets at room temperature in a dry place. Keep the bottle tightly closed and away from moisture, heat, and light. Always keep medicines out of children’s reach. When traveling, carry your supply in original labeled packaging with a copy of your prescription. Pack it in your carry-on to avoid temperature swings. Keep a dosing reminder for time-zone changes. Pharmacies use temperature-controlled handling when required.

Pen Handling and Sharps Disposal

Not applicable. This product is supplied as oral tablets and does not use pens or needles.

Benefits

This dual therapy addresses both glucose production and removal. It can lower fasting and post-meal blood sugars when used as directed. The regimen is taken once daily for many extended-release plans, which may be convenient. The risk of low blood sugar is lower when used without insulin or secretagogues. Some people may notice modest weight change related to increased glucose excretion.

Side Effects and Safety

• Stomach upset: nausea, diarrhea, or abdominal discomfort
• Headache or dizziness
• Increased urination or thirst
• Genital yeast infections
• Urinary tract infections

Serious but less common risks include lactic acidosis with metformin, diabetic ketoacidosis even with near-normal sugars, severe genital infections, dehydration, and acute kidney injury. Hypoglycemia can occur when combined with insulin or sulfonylureas. Seek urgent care for signs of lactic acidosis such as unusual muscle pain, extreme tiredness, trouble breathing, or abdominal pain. Read the Medication Guide and ask your prescriber about warning signs.

Drug Interactions and Cautions

Tell your prescriber about all medicines, vitamins, and herbs you use. Alcohol can raise the risk of lactic acidosis with metformin. Some heart or blood pressure medicines and diuretics can affect hydration and kidney function. Iodinated contrast for imaging may require temporary interruption of metformin. Cimetidine and other drugs that compete for kidney transport may increase metformin levels. Insulin and sulfonylureas can increase hypoglycemia risk when used together. Review your full list with a healthcare professional before starting.

What to Expect Over Time

Many people notice more frequent urination early on; this often settles. Digestive effects like nausea or diarrhea typically improve after the first weeks. Blood sugars may trend down with steady use, and A1C changes are evaluated over months during routine follow-up. Keep using your meal plan, activity goals, and medication as directed. For broader context on therapies, see the Diabetes Drugs List and practical guidance in Insulin Resistance Tips.

Compare With Alternatives

Other prescription options combine metformin with different agents or use distinct classes:

• Canagliflozin plus metformin: see Invokamet® for an SGLT2 + metformin alternative.
• Adding a DPP-4 inhibitor: Sitagliptin may be used alongside metformin for some adults.

Your prescriber can compare benefits and risks for your situation.

Pricing and Access

We offer Canadian pharmacy options with transparent pricing and Ships from Canada to US. To review current options and typical cash-pay approaches, check our catalog under Diabetes Care. If you track the Xigduo XR price, remember amounts can vary by strength, quantity, and pharmacy partner. New offers may be listed on Promotions when available.

Ready to proceed? You can view product pages, upload your prescription, and complete checkout. We verify scripts with your prescriber and coordinate delivery. Category details for Canadian sourcing are summarized under Canada.

Availability and Substitutions

Stock and strengths can fluctuate. If a selected option is unavailable, your prescriber may recommend an equivalent or a different class. Labeling and supply for AstraZeneca Xigduo XR vary by market. We do not promise restock dates. Your order will only be processed once a valid prescription is received and verified.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults needing additional glucose control who can tolerate metformin and SGLT2 therapy. It is not appropriate for type 1 diabetes or active ketoacidosis. Kidney and liver status matter, so recent labs can guide safe use. Discuss hydration plans if you use diuretics.

To manage budget, consider multi-month fills when appropriate, which can reduce per-shipment fees. Set refill reminders so you never run out. Some patients look for Xigduo XR savings through manufacturer support or seasonal offers; availability changes over time. You can compare Canadian pricing across strengths and quantities in our catalog before you place an order.

Questions to Ask Your Clinician

• Starting dose: which strength and timing are right for me?
• Safety checks: what kidney and liver tests do I need?
• Other medicines: which drugs or supplements could raise risks?
• Side effects: what to do if stomach symptoms do not improve?
• Low blood sugar: how to adjust other agents that may cause hypoglycemia?
• Illness and surgery: should I pause doses during dehydration or contrast studies?

Authoritative Sources

FDA Prescribing Information

Health Canada Drug Product Database

Manufacturer Labeling (AstraZeneca)

Ready to order from BorderFreeHealth with US shipping from Canada and prompt, express shipping? Start your request, upload your prescription, and we’ll coordinate verification and fulfilment. This information is educational and not a substitute for medical advice from your prescriber.