Nucala® Pre-filled Auto Injection for Severe Eosinophilic Asthma

What Nucala Is and How It Works

Respiratory biologics can help reduce eosinophil-driven inflammation. This medicine contains mepolizumab, an IL-5 antagonist monoclonal antibody used as add-on maintenance therapy for certain eosinophilic conditions. We provide US shipping from Canada so you can see access options, dosing basics, and storage guidance in one place. You can also review options for Nucala® without insurance and discuss suitability with your prescriber.

Border Free Health connects U.S. patients with licensed Canadian partner pharmacies; prescriptions are verified with prescribers before dispensing.

The treatment targets interleukin-5 to reduce eosinophil levels. Lowering eosinophils can help decrease asthma exacerbations and improve symptom control when used with standard controller medicines. It is not a rescue therapy and does not replace inhaled corticosteroids or bronchodilators.

Who It’s For

This therapy is approved as add-on maintenance for severe eosinophilic asthma in appropriate patients. It is also indicated for eosinophilic granulomatosis with polyangiitis (EGPA), hypereosinophilic syndrome (HES), and chronic rhinosinusitis with nasal polyps (CRSwNP). Suitability depends on your diagnosis, eosinophil levels, age, and your clinician’s judgment. Some people search for Buy mepolizumab prefilled autoinjector, but eligibility and administration route should follow the official label and your prescriber’s plan.

For condition education, see Asthma, EGPA, and Hypereosinophilic Syndrome. For nasal symptoms alongside CRSwNP, related therapies like Omnaris or allergy immunotherapy such as Acarizax may also be discussed with your clinician.

Dosage and Usage

Follow the official label and your prescriber’s instructions. For severe eosinophilic asthma, adults and many adolescents receive a subcutaneous injection once every four weeks. EGPA and HES usually involve higher total dose given subcutaneously every four weeks. For CRSwNP, dosing is typically every four weeks as add-on therapy. Your prescriber determines the exact dose and device based on indication, age, and suitability for at-home administration.

Administration basics: allow the device to reach room temperature before use. Inspect the medicine visually; do not use if you see particles or discoloration. Inject subcutaneously into the thigh or abdomen; a caregiver may use the upper arm. Rotate sites and avoid tender, bruised, or inflamed areas. Do not rub the injection site after use. Continue all controller medicines unless your clinician changes the plan.

This medicine is not for relief of acute bronchospasm or status asthmaticus. Keep your rescue inhaler available and follow your written action plan for sudden symptoms.

Strengths and Forms

Availability may vary by pharmacy and device. Common presentations include:

• Nucala 100 mg/mL single-dose autoinjector for subcutaneous use
• Prefilled syringe for subcutaneous injection
• Vial for reconstitution, administered subcutaneously by a trained professional when indicated

Your prescriber will choose the appropriate device for clinic or at-home use based on the label and your training.

Missed Dose and Timing

If you miss a scheduled injection, take it as soon as you remember, then resume your usual schedule. If the next dose is due soon, ask your prescriber which date to use going forward. Do not take extra doses to make up for a missed injection. Setting reminders, pairing doses with a calendar date, and keeping a written schedule can help with adherence.

Storage and Travel Basics

Store the device in the refrigerator in its original carton to protect from light. Do not freeze or shake. If needed, many labeled devices can be kept at room temperature for a limited period; check the official instructions for allowed duration and conditions. Keep out of reach of children and pets.

For travel, carry the device in an insulated pouch with a copy of your prescription and prescriber details. Use a travel cooler with gel packs if recommended, and avoid direct contact between the device and frozen packs. If your trip spans multiple time zones, plan the schedule with your prescriber so monthly intervals remain consistent. Airlines may request documentation for injectable medicines and sharps.

Our partners use temperature-controlled handling when required, and your order will include the manufacturer’s instructions for use.

Pen Handling and Sharps Disposal

Autoinjector steps may include: warming to room temperature, checking the window, cleaning the site with alcohol, placing at 90 degrees against the skin, and pressing the trigger. Hold for the full time in the instructions so the dose is delivered completely. A caregiver can help if you have limited dexterity. Review the instructions for use provided with your device and practice with your healthcare professional before the first at-home dose.

Discard used devices in an FDA-cleared sharps container. If one is not available, use a heavy-duty household container with a tight-fitting, puncture-resistant lid. Never throw loose needles or autoinjectors into household trash or recycling. Follow local regulations or pharmacy take-back programs for final disposal.

Benefits

This treatment may reduce the rate of severe asthma exacerbations when added to standard therapy. Patients with eosinophilic disease may see fewer oral steroid bursts over time. Some individuals can self-inject at home after training, which can reduce clinic visits and streamline monthly routines. For CRSwNP, it can support polyp and symptom control as part of a broader care plan that may include nasal steroids and saline rinses.

Side Effects and Safety

• Injection site reactions: pain, redness, swelling, itching
• Headache or fatigue
• Back pain or arthralgia
• Upper respiratory tract symptoms

Serious risks can include hypersensitivity reactions, including anaphylaxis, which may occur hours to days after injection. Herpes zoster has been reported; let your clinician know your vaccination status. Parasitic infections may be harder to clear during treatment; manage helminth infections before starting. The therapy is not for acute symptoms. If you feel worse, follow your action plan and contact a healthcare professional.

Drug Interactions and Cautions

Tell your prescriber about all medicines and vaccines. Live vaccines may be deferred. Do not stop oral or inhaled corticosteroids abruptly; any taper should be supervised. Discuss any history of helminth infections, parasitic exposure risk, or immune conditions. Report new or worsening breathing issues, severe rash, swelling, or signs of allergic reaction after any dose.

What to Expect Over Time

Response varies by individual and condition. Your clinician may assess symptoms, rescue inhaler use, and exacerbations across several months to judge benefit. Keep taking controller inhalers as prescribed. Track your symptoms and bring notes to appointments. If you miss a dose, get back on your schedule promptly. Regular follow-up helps adjust your overall asthma or EGPA/HES/CRSwNP plan thoughtfully.

For respiratory health topics, you may like Respiratory Care Week and World Lung Day.

Compare With Alternatives

Other biologics for severe asthma include agents that target IL-5, IL-4/IL-13 pathways, or TSLP. Examples are benralizumab, dupilumab, reslizumab, omalizumab, and tezepelumab, each with distinct indications and criteria. Your prescriber will match therapy to your phenotype, age, biomarkers, comorbidities, and prior response to treatments. If a switch is considered, timing, overlap, and monitoring should follow the label and clinical guidance.

Pricing and Access

We highlight Nucala Canadian pricing so you can compare options and talk with your prescriber about ongoing care. Transparent information helps you plan monthly refills and safe storage. Orders include verification of your prescription before dispensing. We support US delivery from Canada and provide clear checkout steps for your records.

Questions about affordability, copay programs, or payer coverage should be discussed with your clinic and insurer. Many patients use a calendar system to align their injection dates with refill reminders. If you’re exploring coupons, see our current notes on Promotions.

Availability and Substitutions

Supply can vary by device and indication. If the specific device is temporarily unavailable, your prescriber may recommend an appropriate alternative presentation or a different biologic based on your condition and history. We cannot guarantee restock dates. Your pharmacist will communicate any necessary changes for your prescriber’s review.

Patient Suitability and Cost-Saving Tips

This therapy may suit patients with documented eosinophilic disease who continue to have exacerbations despite optimized inhaled therapy. It may not be appropriate for individuals with acute bronchospasm, uncontrolled parasitic infections, or a history of severe hypersensitivity to components. Children have age-specific dosing and device considerations.

To manage costs, ask about multi-month prescription quantities if appropriate, which can reduce pharmacy trips. Set refill reminders on your phone a week before your scheduled date. If you are paying cash, you can explore Nucala self-pay options and compare them with any available insurer or manufacturer support resources your clinic recommends.

Questions to Ask Your Clinician

• Right candidate: what features make me a good fit?
• Dose and schedule: how is my dose determined?
• At-home use: can I self-inject safely after training?
• Other medicines: should I adjust inhalers or steroids?
• Vaccines: any live vaccines to avoid or schedule around?
• Monitoring: what changes should I track between visits?

Authoritative Sources

Manufacturer WebsiteFDA Prescribing InformationHealth Canada DPD

Pricing and Access Help

Ready to move forward? You can start checkout for your prescription with prompt, express shipping that ships from Canada to US. Always use this medicine exactly as prescribed and review the full label before use.